Single-Pill Combination of Telmisartan/Amlodipine in Patients With Severe Hypertension: Results From the TEAMSTA Severe HTN Study

Joel M. Neutel; Giusepe Mancia; Henry R. Black; Bjorn Dahlöf; Holly Defeo; Ludwin Ley; Richard Vinisko; T. Donova; N. Gotcheva; S. Milanov; V. Mincheva; G. Pencheva; N. Zlatareva; D. Raev; S. Stoimenov; S. Petranov; I. Horný; O. Jerábek; I. Karen; J. C. Kuchar; Z. Krumlov Lorenc; J. Nagel; M. Peterka; E. Zídková; F. Barucq; A. Queguiner; F. Robin; P. Touzet; M. Bismuth; M. Bourgoin; C. Giraldi; N. Breton; R. Combet; G. Venturini; P. Causse; F. Henriot; A. Khennouf; D. Lecaignard; P. Cayron; P. Chalaux; A. Chaleon; A. Chalvignac; B. D. Forestier; J. C. Deme; C. Fivel; M. Depoisier; B. Dimon; M. Flosi; A. MacAgno; M. Ripoll; O. Geronimi; B. Michalak; B. Geoffray; E. Hannoush; J. P. Jacquet; L. Jappy; E. Jordan; F. Lacoin; D. Lefort; B. Lemarie; G. Martocq; P. Michellier; E. Nabedian; C. A. Percheron; B. Perrin; M. Pouget; J. J. Roger; G. Rouviere; D. Sacareau; D. Taminau; M. H. Vuong; D. Zimmermann; V. András; T. Lívia; P. Ferenc; N. Gabriella; I. László; P. Ibolya; S. Judit; Z. Károly; R. Judit; I. Benedek; M. Cristea; G. P. Tatu-Chitoiu; S. Dragulescu; D. Gaita; C. A. Georgescu; B. Minescu; I. Manitiu; A. Matei; A. M. Salajan; G. Aroutiounov; I. Gordeev; A. Ivleva; A. Martynov; V. Zadionchenko; A. Filippov; B. Goloshchekin; V. Kostenko; M. Repin; T. Tyurina; A. Vishnevsky; S. H. Baek; S. M. Kang; H. M. Kwon; C. G. Park; M. H. Kim; M. Y. Lee; J. Y. Yang; J. Gonsorcík; S. Hojerová; M. Hranai; V. Kolíková; L. Ruffini; P. Záreczky; B. Gil-Extremera; J. Munoz; J. Oliván; F. Pont; J. L. Tovar; A. Faynyk; B. Goloborodko; V. Shatilo; Y. Sirenko; Y. Svyshchenko; I. Vykhovanyuk; L. Yena; O. Karpenko; L. Kononenko; O. Korzh; I. Kraiz; N. Bittar; D. G. Cheung; K. Crump; J. L. Diaz; R. L. Eddy; R. D. Eyzaguirre; R. J. Graf; J. M. Hill; D. B. Jack; L. Jagminas; B. Kanna; Y. Khronusova; P. J. Lane; L. Levinson; R. Marple; C. J. Mello; N. R. Patel; A. Patron; J. L. Pool; E. B. Portnoy; H. A. Punzi; D. R. Ricci; M. B. Samson; S. Slabic; R. Struble; R. E. Tidman; J. Wayne; D. E. Webster; N. Winer; B. Zehnder

doi:10.1111/j.1751-7176.2012.00595.x

Single-Pill Combination of Telmisartan/Amlodipine in Patients With Severe Hypertension: Results From the TEAMSTA Severe HTN Study

Joel M. Neutel, Giusepe Mancia, Henry R. Black, Bjorn Dahlöf, Holly Defeo, Ludwin Ley, Richard Vinisko, T. Donova, N. Gotcheva, S. Milanov, V. Mincheva, G. Pencheva, N. Zlatareva, D. Raev, S. Stoimenov, S. Petranov, I. Horný, O. Jerábek, I. Karen, J. C. KucharZ. Krumlov Lorenc, J. Nagel, M. Peterka, E. Zídková, F. Barucq, A. Queguiner, F. Robin, P. Touzet, M. Bismuth, M. Bourgoin, C. Giraldi, N. Breton, R. Combet, G. Venturini, P. Causse, F. Henriot, A. Khennouf, D. Lecaignard, P. Cayron, P. Chalaux, A. Chaleon, A. Chalvignac, B. D. Forestier, J. C. Deme, C. Fivel, M. Depoisier, B. Dimon, M. Flosi, A. MacAgno, M. Ripoll, O. Geronimi, B. Michalak, B. Geoffray, E. Hannoush, J. P. Jacquet, L. Jappy, E. Jordan, F. Lacoin, D. Lefort, B. Lemarie, G. Martocq, P. Michellier, E. Nabedian, C. A. Percheron, B. Perrin, M. Pouget, J. J. Roger, G. Rouviere, D. Sacareau, D. Taminau, M. H. Vuong, D. Zimmermann, V. András, T. Lívia, P. Ferenc, N. Gabriella, I. László, P. Ibolya, S. Judit, Z. Károly, R. Judit, I. Benedek, M. Cristea, G. P. Tatu-Chitoiu, S. Dragulescu, D. Gaita, C. A. Georgescu, B. Minescu, I. Manitiu, A. Matei, A. M. Salajan, G. Aroutiounov, I. Gordeev, A. Ivleva, A. Martynov, V. Zadionchenko, A. Filippov, B. Goloshchekin, V. Kostenko, M. Repin, T. Tyurina, A. Vishnevsky, S. H. Baek, S. M. Kang, H. M. Kwon, C. G. Park, M. H. Kim, M. Y. Lee, J. Y. Yang, J. Gonsorcík, S. Hojerová, M. Hranai, V. Kolíková, L. Ruffini, P. Záreczky, B. Gil-Extremera, J. Munoz, J. Oliván, F. Pont, J. L. Tovar, A. Faynyk, B. Goloborodko, V. Shatilo, Y. Sirenko, Y. Svyshchenko, I. Vykhovanyuk, L. Yena, O. Karpenko, L. Kononenko, O. Korzh, I. Kraiz, N. Bittar, D. G. Cheung, K. Crump, J. L. Diaz, R. L. Eddy, R. D. Eyzaguirre, R. J. Graf, J. M. Hill, D. B. Jack, L. Jagminas, B. Kanna, Y. Khronusova, P. J. Lane, L. Levinson, R. Marple, C. J. Mello, N. R. Patel, A. Patron, J. L. Pool, E. B. Portnoy, H. A. Punzi, D. R. Ricci, M. B. Samson, S. Slabic, R. Struble, R. E. Tidman, J. Wayne, D. E. Webster, N. Winer, B. Zehnder

Department of Internal Medicine

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30 Citations (Scopus)

Abstract

This 8-week, randomized, double-blind, controlled study compared efficacy and tolerability of telmisartan/amlodipine (T/A) single-pill combination (SPC) vs the respective monotherapies in 858 patients with severe hypertension (systolic/diastolic blood pressure [SBP/DBP] ≥180/95 mmHg). At 8weeks, T/A provided significantly greater reductions from baseline in seated trough cuff SBP/DBP (-47.5mmHg/-18.7mmHg) vs T (P<.0001) or A (P=.0002) monotherapy; superior reductions were also evident at 1, 2, 4, and 6weeks. Blood pressure (BP) goal and response rates were consistently higher with T/A vs T or A. T/A was well tolerated, with less frequent treatment-related adverse events vs A (12.6% vs 16.4%) and a numerically lower incidence of peripheral edema and treatment discontinuation. In conclusion, treatment of patients with substantially elevated BP with T/A SPCs resulted in high and significantly greater BP reductions and higher BP goal and response rates than the respective monotherapies. T/A SPCs were well tolerated.

Original language	English
Pages (from-to)	206-215
Number of pages	10
Journal	Journal of Clinical Hypertension
Volume	14
Issue number	4
DOIs	https://doi.org/10.1111/j.1751-7176.2012.00595.x
Publication status	Published - 2012 Apr

All Science Journal Classification (ASJC) codes

Internal Medicine
Endocrinology, Diabetes and Metabolism
Cardiology and Cardiovascular Medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/j.1751-7176.2012.00595.x

Cite this

Neutel, J. M., Mancia, G., Black, H. R., Dahlöf, B., Defeo, H., Ley, L., Vinisko, R., Donova, T., Gotcheva, N., Milanov, S., Mincheva, V., Pencheva, G., Zlatareva, N., Raev, D., Stoimenov, S., Petranov, S., Horný, I., Jerábek, O., Karen, I., ... Zehnder, B. (2012). Single-Pill Combination of Telmisartan/Amlodipine in Patients With Severe Hypertension: Results From the TEAMSTA Severe HTN Study. Journal of Clinical Hypertension, 14(4), 206-215. https://doi.org/10.1111/j.1751-7176.2012.00595.x

@article{5e2fc736dc6b444489bac8707eaa3549,

title = "Single-Pill Combination of Telmisartan/Amlodipine in Patients With Severe Hypertension: Results From the TEAMSTA Severe HTN Study",

abstract = "This 8-week, randomized, double-blind, controlled study compared efficacy and tolerability of telmisartan/amlodipine (T/A) single-pill combination (SPC) vs the respective monotherapies in 858 patients with severe hypertension (systolic/diastolic blood pressure [SBP/DBP] ≥180/95 mmHg). At 8weeks, T/A provided significantly greater reductions from baseline in seated trough cuff SBP/DBP (-47.5mmHg/-18.7mmHg) vs T (P<.0001) or A (P=.0002) monotherapy; superior reductions were also evident at 1, 2, 4, and 6weeks. Blood pressure (BP) goal and response rates were consistently higher with T/A vs T or A. T/A was well tolerated, with less frequent treatment-related adverse events vs A (12.6% vs 16.4%) and a numerically lower incidence of peripheral edema and treatment discontinuation. In conclusion, treatment of patients with substantially elevated BP with T/A SPCs resulted in high and significantly greater BP reductions and higher BP goal and response rates than the respective monotherapies. T/A SPCs were well tolerated.",

author = "Neutel, {Joel M.} and Giusepe Mancia and Black, {Henry R.} and Bjorn Dahl{\"o}f and Holly Defeo and Ludwin Ley and Richard Vinisko and T. Donova and N. Gotcheva and S. Milanov and V. Mincheva and G. Pencheva and N. Zlatareva and D. Raev and S. Stoimenov and S. Petranov and I. Horn{\'y} and O. Jer{\'a}bek and I. Karen and Kuchar, {J. C.} and {Krumlov Lorenc}, Z. and J. Nagel and M. Peterka and E. Z{\'i}dkov{\'a} and F. Barucq and A. Queguiner and F. Robin and P. Touzet and M. Bismuth and M. Bourgoin and C. Giraldi and N. Breton and R. Combet and G. Venturini and P. Causse and F. Henriot and A. Khennouf and D. Lecaignard and P. Cayron and P. Chalaux and A. Chaleon and A. Chalvignac and Forestier, {B. D.} and Deme, {J. C.} and C. Fivel and M. Depoisier and B. Dimon and M. Flosi and A. MacAgno and M. Ripoll and O. Geronimi and B. Michalak and B. Geoffray and E. Hannoush and Jacquet, {J. P.} and L. Jappy and E. Jordan and F. Lacoin and D. Lefort and B. Lemarie and G. Martocq and P. Michellier and E. Nabedian and Percheron, {C. A.} and B. Perrin and M. Pouget and Roger, {J. J.} and G. Rouviere and D. Sacareau and D. Taminau and Vuong, {M. H.} and D. Zimmermann and V. Andr{\'a}s and T. L{\'i}via and P. Ferenc and N. Gabriella and I. L{\'a}szl{\'o} and P. Ibolya and S. Judit and Z. K{\'a}roly and R. Judit and I. Benedek and M. Cristea and Tatu-Chitoiu, {G. P.} and S. Dragulescu and D. Gaita and Georgescu, {C. A.} and B. Minescu and I. Manitiu and A. Matei and Salajan, {A. M.} and G. Aroutiounov and I. Gordeev and A. Ivleva and A. Martynov and V. Zadionchenko and A. Filippov and B. Goloshchekin and V. Kostenko and M. Repin and T. Tyurina and A. Vishnevsky and Baek, {S. H.} and Kang, {S. M.} and Kwon, {H. M.} and Park, {C. G.} and Kim, {M. H.} and Lee, {M. Y.} and Yang, {J. Y.} and J. Gonsorc{\'i}k and S. Hojerov{\'a} and M. Hranai and V. Kol{\'i}kov{\'a} and L. Ruffini and P. Z{\'a}reczky and B. Gil-Extremera and J. Munoz and J. Oliv{\'a}n and F. Pont and Tovar, {J. L.} and A. Faynyk and B. Goloborodko and V. Shatilo and Y. Sirenko and Y. Svyshchenko and I. Vykhovanyuk and L. Yena and O. Karpenko and L. Kononenko and O. Korzh and I. Kraiz and N. Bittar and Cheung, {D. G.} and K. Crump and Diaz, {J. L.} and Eddy, {R. L.} and Eyzaguirre, {R. D.} and Graf, {R. J.} and Hill, {J. M.} and Jack, {D. B.} and L. Jagminas and B. Kanna and Y. Khronusova and Lane, {P. J.} and L. Levinson and R. Marple and Mello, {C. J.} and Patel, {N. R.} and A. Patron and Pool, {J. L.} and Portnoy, {E. B.} and Punzi, {H. A.} and Ricci, {D. R.} and Samson, {M. B.} and S. Slabic and R. Struble and Tidman, {R. E.} and J. Wayne and Webster, {D. E.} and N. Winer and B. Zehnder",

year = "2012",

month = apr,

doi = "10.1111/j.1751-7176.2012.00595.x",

language = "English",

volume = "14",

pages = "206--215",

journal = "Journal of Clinical Hypertension",

issn = "1524-6175",

publisher = "Wiley-Blackwell",

number = "4",

}

Neutel, JM, Mancia, G, Black, HR, Dahlöf, B, Defeo, H, Ley, L, Vinisko, R, Donova, T, Gotcheva, N, Milanov, S, Mincheva, V, Pencheva, G, Zlatareva, N, Raev, D, Stoimenov, S, Petranov, S, Horný, I, Jerábek, O, Karen, I, Kuchar, JC, Krumlov Lorenc, Z, Nagel, J, Peterka, M, Zídková, E, Barucq, F, Queguiner, A, Robin, F, Touzet, P, Bismuth, M, Bourgoin, M, Giraldi, C, Breton, N, Combet, R, Venturini, G, Causse, P, Henriot, F, Khennouf, A, Lecaignard, D, Cayron, P, Chalaux, P, Chaleon, A, Chalvignac, A, Forestier, BD, Deme, JC, Fivel, C, Depoisier, M, Dimon, B, Flosi, M, MacAgno, A, Ripoll, M, Geronimi, O, Michalak, B, Geoffray, B, Hannoush, E, Jacquet, JP, Jappy, L, Jordan, E, Lacoin, F, Lefort, D, Lemarie, B, Martocq, G, Michellier, P, Nabedian, E, Percheron, CA, Perrin, B, Pouget, M, Roger, JJ, Rouviere, G, Sacareau, D, Taminau, D, Vuong, MH, Zimmermann, D, András, V, Lívia, T, Ferenc, P, Gabriella, N, László, I, Ibolya, P, Judit, S, Károly, Z, Judit, R, Benedek, I, Cristea, M, Tatu-Chitoiu, GP, Dragulescu, S, Gaita, D, Georgescu, CA, Minescu, B, Manitiu, I, Matei, A, Salajan, AM, Aroutiounov, G, Gordeev, I, Ivleva, A, Martynov, A, Zadionchenko, V, Filippov, A, Goloshchekin, B, Kostenko, V, Repin, M, Tyurina, T, Vishnevsky, A, Baek, SH, Kang, SM, Kwon, HM, Park, CG, Kim, MH, Lee, MY, Yang, JY, Gonsorcík, J, Hojerová, S, Hranai, M, Kolíková, V, Ruffini, L, Záreczky, P, Gil-Extremera, B, Munoz, J, Oliván, J, Pont, F, Tovar, JL, Faynyk, A, Goloborodko, B, Shatilo, V, Sirenko, Y, Svyshchenko, Y, Vykhovanyuk, I, Yena, L, Karpenko, O, Kononenko, L, Korzh, O, Kraiz, I, Bittar, N, Cheung, DG, Crump, K, Diaz, JL, Eddy, RL, Eyzaguirre, RD, Graf, RJ, Hill, JM, Jack, DB, Jagminas, L, Kanna, B, Khronusova, Y, Lane, PJ, Levinson, L, Marple, R, Mello, CJ, Patel, NR, Patron, A, Pool, JL, Portnoy, EB, Punzi, HA, Ricci, DR, Samson, MB, Slabic, S, Struble, R, Tidman, RE, Wayne, J, Webster, DE, Winer, N & Zehnder, B 2012, 'Single-Pill Combination of Telmisartan/Amlodipine in Patients With Severe Hypertension: Results From the TEAMSTA Severe HTN Study', Journal of Clinical Hypertension, vol. 14, no. 4, pp. 206-215. https://doi.org/10.1111/j.1751-7176.2012.00595.x

TY - JOUR

T1 - Single-Pill Combination of Telmisartan/Amlodipine in Patients With Severe Hypertension

T2 - Results From the TEAMSTA Severe HTN Study

AU - Neutel, Joel M.

AU - Mancia, Giusepe

AU - Black, Henry R.

AU - Dahlöf, Bjorn

AU - Defeo, Holly

AU - Ley, Ludwin

AU - Vinisko, Richard

AU - Donova, T.

AU - Gotcheva, N.

AU - Milanov, S.

AU - Mincheva, V.

AU - Pencheva, G.

AU - Zlatareva, N.

AU - Raev, D.

AU - Stoimenov, S.

AU - Petranov, S.

AU - Horný, I.

AU - Jerábek, O.

AU - Karen, I.

AU - Kuchar, J. C.

AU - Krumlov Lorenc, Z.

AU - Nagel, J.

AU - Peterka, M.

AU - Zídková, E.

AU - Barucq, F.

AU - Queguiner, A.

AU - Robin, F.

AU - Touzet, P.

AU - Bismuth, M.

AU - Bourgoin, M.

AU - Giraldi, C.

AU - Breton, N.

AU - Combet, R.

AU - Venturini, G.

AU - Causse, P.

AU - Henriot, F.

AU - Khennouf, A.

AU - Lecaignard, D.

AU - Cayron, P.

AU - Chalaux, P.

AU - Chaleon, A.

AU - Chalvignac, A.

AU - Forestier, B. D.

AU - Deme, J. C.

AU - Fivel, C.

AU - Depoisier, M.

AU - Dimon, B.

AU - Flosi, M.

AU - MacAgno, A.

AU - Ripoll, M.

AU - Geronimi, O.

AU - Michalak, B.

AU - Geoffray, B.

AU - Hannoush, E.

AU - Jacquet, J. P.

AU - Jappy, L.

AU - Jordan, E.

AU - Lacoin, F.

AU - Lefort, D.

AU - Lemarie, B.

AU - Martocq, G.

AU - Michellier, P.

AU - Nabedian, E.

AU - Percheron, C. A.

AU - Perrin, B.

AU - Pouget, M.

AU - Roger, J. J.

AU - Rouviere, G.

AU - Sacareau, D.

AU - Taminau, D.

AU - Vuong, M. H.

AU - Zimmermann, D.

AU - András, V.

AU - Lívia, T.

AU - Ferenc, P.

AU - Gabriella, N.

AU - László, I.

AU - Ibolya, P.

AU - Judit, S.

AU - Károly, Z.

AU - Judit, R.

AU - Benedek, I.

AU - Cristea, M.

AU - Tatu-Chitoiu, G. P.

AU - Dragulescu, S.

AU - Gaita, D.

AU - Georgescu, C. A.

AU - Minescu, B.

AU - Manitiu, I.

AU - Matei, A.

AU - Salajan, A. M.

AU - Aroutiounov, G.

AU - Gordeev, I.

AU - Ivleva, A.

AU - Martynov, A.

AU - Zadionchenko, V.

AU - Filippov, A.

AU - Goloshchekin, B.

AU - Kostenko, V.

AU - Repin, M.

AU - Tyurina, T.

AU - Vishnevsky, A.

AU - Baek, S. H.

AU - Kang, S. M.

AU - Kwon, H. M.

AU - Park, C. G.

AU - Kim, M. H.

AU - Lee, M. Y.

AU - Yang, J. Y.

AU - Gonsorcík, J.

AU - Hojerová, S.

AU - Hranai, M.

AU - Kolíková, V.

AU - Ruffini, L.

AU - Záreczky, P.

AU - Gil-Extremera, B.

AU - Munoz, J.

AU - Oliván, J.

AU - Pont, F.

AU - Tovar, J. L.

AU - Faynyk, A.

AU - Goloborodko, B.

AU - Shatilo, V.

AU - Sirenko, Y.

AU - Svyshchenko, Y.

AU - Vykhovanyuk, I.

AU - Yena, L.

AU - Karpenko, O.

AU - Kononenko, L.

AU - Korzh, O.

AU - Kraiz, I.

AU - Bittar, N.

AU - Cheung, D. G.

AU - Crump, K.

AU - Diaz, J. L.

AU - Eddy, R. L.

AU - Eyzaguirre, R. D.

AU - Graf, R. J.

AU - Hill, J. M.

AU - Jack, D. B.

AU - Jagminas, L.

AU - Kanna, B.

AU - Khronusova, Y.

AU - Lane, P. J.

AU - Levinson, L.

AU - Marple, R.

AU - Mello, C. J.

AU - Patel, N. R.

AU - Patron, A.

AU - Pool, J. L.

AU - Portnoy, E. B.

AU - Punzi, H. A.

AU - Ricci, D. R.

AU - Samson, M. B.

AU - Slabic, S.

AU - Struble, R.

AU - Tidman, R. E.

AU - Wayne, J.

AU - Webster, D. E.

AU - Winer, N.

AU - Zehnder, B.

PY - 2012/4

Y1 - 2012/4

N2 - This 8-week, randomized, double-blind, controlled study compared efficacy and tolerability of telmisartan/amlodipine (T/A) single-pill combination (SPC) vs the respective monotherapies in 858 patients with severe hypertension (systolic/diastolic blood pressure [SBP/DBP] ≥180/95 mmHg). At 8weeks, T/A provided significantly greater reductions from baseline in seated trough cuff SBP/DBP (-47.5mmHg/-18.7mmHg) vs T (P<.0001) or A (P=.0002) monotherapy; superior reductions were also evident at 1, 2, 4, and 6weeks. Blood pressure (BP) goal and response rates were consistently higher with T/A vs T or A. T/A was well tolerated, with less frequent treatment-related adverse events vs A (12.6% vs 16.4%) and a numerically lower incidence of peripheral edema and treatment discontinuation. In conclusion, treatment of patients with substantially elevated BP with T/A SPCs resulted in high and significantly greater BP reductions and higher BP goal and response rates than the respective monotherapies. T/A SPCs were well tolerated.

AB - This 8-week, randomized, double-blind, controlled study compared efficacy and tolerability of telmisartan/amlodipine (T/A) single-pill combination (SPC) vs the respective monotherapies in 858 patients with severe hypertension (systolic/diastolic blood pressure [SBP/DBP] ≥180/95 mmHg). At 8weeks, T/A provided significantly greater reductions from baseline in seated trough cuff SBP/DBP (-47.5mmHg/-18.7mmHg) vs T (P<.0001) or A (P=.0002) monotherapy; superior reductions were also evident at 1, 2, 4, and 6weeks. Blood pressure (BP) goal and response rates were consistently higher with T/A vs T or A. T/A was well tolerated, with less frequent treatment-related adverse events vs A (12.6% vs 16.4%) and a numerically lower incidence of peripheral edema and treatment discontinuation. In conclusion, treatment of patients with substantially elevated BP with T/A SPCs resulted in high and significantly greater BP reductions and higher BP goal and response rates than the respective monotherapies. T/A SPCs were well tolerated.

UR - http://www.scopus.com/inward/record.url?scp=84862783629&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84862783629&partnerID=8YFLogxK

U2 - 10.1111/j.1751-7176.2012.00595.x

DO - 10.1111/j.1751-7176.2012.00595.x

M3 - Article

C2 - 22458741

AN - SCOPUS:84862783629

SN - 1524-6175

VL - 14

SP - 206

EP - 215

JO - Journal of Clinical Hypertension

JF - Journal of Clinical Hypertension

IS - 4

ER -

Single-Pill Combination of Telmisartan/Amlodipine in Patients With Severe Hypertension: Results From the TEAMSTA Severe HTN Study

Abstract

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UN SDGs

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