Single-Pill Combination of Telmisartan/Amlodipine in Patients With Severe Hypertension: Results From the TEAMSTA Severe HTN Study

Joel M. Neutel, Giusepe Mancia, Henry R. Black, Bjorn Dahlöf, Holly Defeo, Ludwin Ley, Richard Vinisko, T. Donova, N. Gotcheva, S. Milanov, V. Mincheva, G. Pencheva, N. Zlatareva, D. Raev, S. Stoimenov, S. Petranov, I. Horný, O. Jerábek, I. Karen, J. C. KucharZ. Krumlov Lorenc, J. Nagel, M. Peterka, E. Zídková, F. Barucq, A. Queguiner, F. Robin, P. Touzet, M. Bismuth, M. Bourgoin, C. Giraldi, N. Breton, R. Combet, G. Venturini, P. Causse, F. Henriot, A. Khennouf, D. Lecaignard, P. Cayron, P. Chalaux, A. Chaleon, A. Chalvignac, B. D. Forestier, J. C. Deme, C. Fivel, M. Depoisier, B. Dimon, M. Flosi, A. MacAgno, M. Ripoll, O. Geronimi, B. Michalak, B. Geoffray, E. Hannoush, J. P. Jacquet, L. Jappy, E. Jordan, F. Lacoin, D. Lefort, B. Lemarie, G. Martocq, P. Michellier, E. Nabedian, C. A. Percheron, B. Perrin, M. Pouget, J. J. Roger, G. Rouviere, D. Sacareau, D. Taminau, M. H. Vuong, D. Zimmermann, V. András, T. Lívia, P. Ferenc, N. Gabriella, I. László, P. Ibolya, S. Judit, Z. Károly, R. Judit, I. Benedek, M. Cristea, G. P. Tatu-Chitoiu, S. Dragulescu, D. Gaita, C. A. Georgescu, B. Minescu, I. Manitiu, A. Matei, A. M. Salajan, G. Aroutiounov, I. Gordeev, A. Ivleva, A. Martynov, V. Zadionchenko, A. Filippov, B. Goloshchekin, V. Kostenko, M. Repin, T. Tyurina, A. Vishnevsky, S. H. Baek, S. M. Kang, H. M. Kwon, C. G. Park, M. H. Kim, M. Y. Lee, J. Y. Yang, J. Gonsorcík, S. Hojerová, M. Hranai, V. Kolíková, L. Ruffini, P. Záreczky, B. Gil-Extremera, J. Munoz, J. Oliván, F. Pont, J. L. Tovar, A. Faynyk, B. Goloborodko, V. Shatilo, Y. Sirenko, Y. Svyshchenko, I. Vykhovanyuk, L. Yena, O. Karpenko, L. Kononenko, O. Korzh, I. Kraiz, N. Bittar, D. G. Cheung, K. Crump, J. L. Diaz, R. L. Eddy, R. D. Eyzaguirre, R. J. Graf, J. M. Hill, D. B. Jack, L. Jagminas, B. Kanna, Y. Khronusova, P. J. Lane, L. Levinson, R. Marple, C. J. Mello, N. R. Patel, A. Patron, J. L. Pool, E. B. Portnoy, H. A. Punzi, D. R. Ricci, M. B. Samson, S. Slabic, R. Struble, R. E. Tidman, J. Wayne, D. E. Webster, N. Winer, B. Zehnder

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Abstract

This 8-week, randomized, double-blind, controlled study compared efficacy and tolerability of telmisartan/amlodipine (T/A) single-pill combination (SPC) vs the respective monotherapies in 858 patients with severe hypertension (systolic/diastolic blood pressure [SBP/DBP] ≥180/95 mmHg). At 8weeks, T/A provided significantly greater reductions from baseline in seated trough cuff SBP/DBP (-47.5mmHg/-18.7mmHg) vs T (P<.0001) or A (P=.0002) monotherapy; superior reductions were also evident at 1, 2, 4, and 6weeks. Blood pressure (BP) goal and response rates were consistently higher with T/A vs T or A. T/A was well tolerated, with less frequent treatment-related adverse events vs A (12.6% vs 16.4%) and a numerically lower incidence of peripheral edema and treatment discontinuation. In conclusion, treatment of patients with substantially elevated BP with T/A SPCs resulted in high and significantly greater BP reductions and higher BP goal and response rates than the respective monotherapies. T/A SPCs were well tolerated.

Original languageEnglish
Pages (from-to)206-215
Number of pages10
JournalJournal of Clinical Hypertension
Volume14
Issue number4
DOIs
Publication statusPublished - 2012 Apr 1

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All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Cardiology and Cardiovascular Medicine

Cite this

Neutel, J. M., Mancia, G., Black, H. R., Dahlöf, B., Defeo, H., Ley, L., Vinisko, R., Donova, T., Gotcheva, N., Milanov, S., Mincheva, V., Pencheva, G., Zlatareva, N., Raev, D., Stoimenov, S., Petranov, S., Horný, I., Jerábek, O., Karen, I., ... Zehnder, B. (2012). Single-Pill Combination of Telmisartan/Amlodipine in Patients With Severe Hypertension: Results From the TEAMSTA Severe HTN Study. Journal of Clinical Hypertension, 14(4), 206-215. https://doi.org/10.1111/j.1751-7176.2012.00595.x