Singlet oxygen generating nanolayer coatings on NiTi alloy for photodynamic application

Kyong Hoon Choi, Kang Kyun Wang, Seung Lim Oh, Ji Eun Im, Bong Jin Kim, Jong Chul Park, Dong Hoon Choi, Hwan Kyu Kim, Yong Rok Kim

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Photodynamic Therapy (PDT) is a promising approach for killing microorganism and especially for the inactivation of antibiotic-resistant strains. The photodynamic process rapidly generates reactive oxygen species (ROS) as for instance peroxides, hydroxyl radicals, superoxide ions, and singlet oxygen. Among them, the singlet oxygen is considered to be a major causative agent of cellular damage in photodynamic process. Due to advantage of the cytotoxic effect of PDT on bacteria, the PDT method has been one of the most appropriate tools to prevent the microbes which result in biofilm formation. This work describes a method of singlet oxygen generating nanolayer coating on NiTi alloy which shows a good biocompatibility. The 5,10,15-triphenyl-20-(4-carboxyphenyl)-porphyrin] platinum (PtCP) functional nanolayer coatings were prepared in two steps. In the first step, Al coating was prepared on biomedical NiTi alloy substrate by DC magnetron sputtering, and then this coated substrate alloy was immersed into hot water to form Al2O3 coatings. In the second step, a photosensitizer (PS) with carboxyl group was chemically attached to the hydroxyl-terminated Al2O3 coatings by a direct esterification method. The microstructure and the elemental and phase composition of the coating were investigated by scanning electron microscopy (SEM), energy dispersive X-ray spectrometer (EDS), and X-ray diffraction (XRD). Results from this study show that the PtCP functional nanolayer coating is composed of many perpendicular nanosheet structures. These very thin nanosheet structures with the thickness of a few nanometers mainly show amorphous phase. The singlet oxygen generation efficiency of the PS being chemically bonded on these nanosheets was detected by an indirect chemical method by using the decomposition of 1,3-diphenyl-isobenzofuran (DPBF).

Original languageEnglish
Pages (from-to)S62-S67
JournalSurface and Coatings Technology
Volume205
Issue numberSUPPL. 1
DOIs
Publication statusPublished - 2010 Dec 25

Fingerprint

Singlet Oxygen
coatings
Coatings
Oxygen
oxygen
Photodynamic therapy
Nanosheets
therapy
Photosensitizing Agents
Photosensitizers
microorganisms
Hydroxyl Radical
X ray spectrometers
biofilms
antibiotics
inorganic peroxides
Porphyrins
Peroxides
hydroxyl radicals
Esterification

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Condensed Matter Physics
  • Surfaces and Interfaces
  • Surfaces, Coatings and Films
  • Materials Chemistry

Cite this

Choi, Kyong Hoon ; Wang, Kang Kyun ; Oh, Seung Lim ; Im, Ji Eun ; Kim, Bong Jin ; Park, Jong Chul ; Choi, Dong Hoon ; Kim, Hwan Kyu ; Kim, Yong Rok. / Singlet oxygen generating nanolayer coatings on NiTi alloy for photodynamic application. In: Surface and Coatings Technology. 2010 ; Vol. 205, No. SUPPL. 1. pp. S62-S67.
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Singlet oxygen generating nanolayer coatings on NiTi alloy for photodynamic application. / Choi, Kyong Hoon; Wang, Kang Kyun; Oh, Seung Lim; Im, Ji Eun; Kim, Bong Jin; Park, Jong Chul; Choi, Dong Hoon; Kim, Hwan Kyu; Kim, Yong Rok.

In: Surface and Coatings Technology, Vol. 205, No. SUPPL. 1, 25.12.2010, p. S62-S67.

Research output: Contribution to journalArticle

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T1 - Singlet oxygen generating nanolayer coatings on NiTi alloy for photodynamic application

AU - Choi, Kyong Hoon

AU - Wang, Kang Kyun

AU - Oh, Seung Lim

AU - Im, Ji Eun

AU - Kim, Bong Jin

AU - Park, Jong Chul

AU - Choi, Dong Hoon

AU - Kim, Hwan Kyu

AU - Kim, Yong Rok

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Y1 - 2010/12/25

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AB - Photodynamic Therapy (PDT) is a promising approach for killing microorganism and especially for the inactivation of antibiotic-resistant strains. The photodynamic process rapidly generates reactive oxygen species (ROS) as for instance peroxides, hydroxyl radicals, superoxide ions, and singlet oxygen. Among them, the singlet oxygen is considered to be a major causative agent of cellular damage in photodynamic process. Due to advantage of the cytotoxic effect of PDT on bacteria, the PDT method has been one of the most appropriate tools to prevent the microbes which result in biofilm formation. This work describes a method of singlet oxygen generating nanolayer coating on NiTi alloy which shows a good biocompatibility. The 5,10,15-triphenyl-20-(4-carboxyphenyl)-porphyrin] platinum (PtCP) functional nanolayer coatings were prepared in two steps. In the first step, Al coating was prepared on biomedical NiTi alloy substrate by DC magnetron sputtering, and then this coated substrate alloy was immersed into hot water to form Al2O3 coatings. In the second step, a photosensitizer (PS) with carboxyl group was chemically attached to the hydroxyl-terminated Al2O3 coatings by a direct esterification method. The microstructure and the elemental and phase composition of the coating were investigated by scanning electron microscopy (SEM), energy dispersive X-ray spectrometer (EDS), and X-ray diffraction (XRD). Results from this study show that the PtCP functional nanolayer coating is composed of many perpendicular nanosheet structures. These very thin nanosheet structures with the thickness of a few nanometers mainly show amorphous phase. The singlet oxygen generation efficiency of the PS being chemically bonded on these nanosheets was detected by an indirect chemical method by using the decomposition of 1,3-diphenyl-isobenzofuran (DPBF).

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