Sinonasal pleomorphic adenoma: A single institution case series combined with a comprehensive review of literatures

Min Seok Rha, Sewon Jeong, Hyung Ju Cho, Joo Heon Yoon, Chang-Hoon Kim

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Abstract

Objective: This study aimed to reveal diagnosis, management, and treatment outcome characteristics of sinonasal pleomorphic adenoma and to identify predictors for disease recurrence. Methods: This study comprised a retrospective review of data from seven patients with sinonasal pleomorphic adenoma who were treated by the authors at a tertiary medical center between January 2005 and May 2017. In addition, the MEDLINE database was searched for literature published in English. A systematic review of the published articles was performed. Results: A total of 42 articles were eligible for review. Data from the seven treated patients and 101 patients described in the literature were included in the analysis. An endoscopic approach was employed in all cases treated at our institution, and recurrence was found in one patient with a large, 5.5-cm tumor. In reviewing prior publications, the mean age at surgery was 45.4 years, and the primary sign at diagnosis was nasal obstruction. The most common primary tumor site was the nasal septum (57.4%), and the mean tumor size was 3.6 cm (range, 0.5–10 cm) in 76 cases for which detailed information was available. Endoscopic endonasal resection achieved successful oncologic control in applied cases (25/25, 100%). Recurrence was found in eight of 101 patients. Multivariate analysis identified tumor origin of the paranasal sinus (adjusted OR 31.000, p = 0.016) as being significantly associated with a high prevalence of recurrence. Conclusion: Pleomorphic adenoma is a rare benign tumor of the sinonasal tract. Surgery that achieves clear margins is the treatment of choice. The tumor may be accessible via an endoscopic endonasal approach in most cases, although incomplete resection of the tumor stem may allow for tumor recurrence. In addition, our findings suggest that a tumor originating from the paranasal sinus is significantly associated with a high prevalence of recurrence.

Original languageEnglish
Pages (from-to)223-229
Number of pages7
JournalAuris Nasus Larynx
Volume46
Issue number2
DOIs
Publication statusPublished - 2019 Apr 1

Fingerprint

Pleomorphic Adenoma
Recurrence
Neoplasms
Paranasal Sinuses
Nasal Septum
Nasal Obstruction
MEDLINE
Publications
Multivariate Analysis
Databases

All Science Journal Classification (ASJC) codes

  • Surgery
  • Otorhinolaryngology

Cite this

Rha, Min Seok ; Jeong, Sewon ; Cho, Hyung Ju ; Yoon, Joo Heon ; Kim, Chang-Hoon. / Sinonasal pleomorphic adenoma : A single institution case series combined with a comprehensive review of literatures. In: Auris Nasus Larynx. 2019 ; Vol. 46, No. 2. pp. 223-229.
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abstract = "Objective: This study aimed to reveal diagnosis, management, and treatment outcome characteristics of sinonasal pleomorphic adenoma and to identify predictors for disease recurrence. Methods: This study comprised a retrospective review of data from seven patients with sinonasal pleomorphic adenoma who were treated by the authors at a tertiary medical center between January 2005 and May 2017. In addition, the MEDLINE database was searched for literature published in English. A systematic review of the published articles was performed. Results: A total of 42 articles were eligible for review. Data from the seven treated patients and 101 patients described in the literature were included in the analysis. An endoscopic approach was employed in all cases treated at our institution, and recurrence was found in one patient with a large, 5.5-cm tumor. In reviewing prior publications, the mean age at surgery was 45.4 years, and the primary sign at diagnosis was nasal obstruction. The most common primary tumor site was the nasal septum (57.4{\%}), and the mean tumor size was 3.6 cm (range, 0.5–10 cm) in 76 cases for which detailed information was available. Endoscopic endonasal resection achieved successful oncologic control in applied cases (25/25, 100{\%}). Recurrence was found in eight of 101 patients. Multivariate analysis identified tumor origin of the paranasal sinus (adjusted OR 31.000, p = 0.016) as being significantly associated with a high prevalence of recurrence. Conclusion: Pleomorphic adenoma is a rare benign tumor of the sinonasal tract. Surgery that achieves clear margins is the treatment of choice. The tumor may be accessible via an endoscopic endonasal approach in most cases, although incomplete resection of the tumor stem may allow for tumor recurrence. In addition, our findings suggest that a tumor originating from the paranasal sinus is significantly associated with a high prevalence of recurrence.",
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Sinonasal pleomorphic adenoma : A single institution case series combined with a comprehensive review of literatures. / Rha, Min Seok; Jeong, Sewon; Cho, Hyung Ju; Yoon, Joo Heon; Kim, Chang-Hoon.

In: Auris Nasus Larynx, Vol. 46, No. 2, 01.04.2019, p. 223-229.

Research output: Contribution to journalArticle

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