Sinus augmentation using BMP-2 in a bovine hydroxyapatite/collagen carrier in dogs

Jae Kook Cha, Jung Seok Lee, Min Soo Kim, Seongho Choi, Kyoo Sung Cho, Ui-Won Jung

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Aim The objective of this study was to determine the efficacy of bone morphogenetic protein 2 (BMP-2) in a bovine hydroxyapatite/collagen (BHC) carrier to augment bone formation in a canine nasal sinus model. Methods Eight mongrel dogs, approximately 12 months old and 30 kg in weight were used. Following preparation of bilateral sinus access windows, BHC alone (control) or loaded with E. coli-derived BMP-2 at 0.1 mg/ml was implanted in four animals, and BHC loaded with E. coli-derived BMP-2 at 0.5 and 1.5 mg/ml was implanted in four animals. The animals were euthanized at 20 weeks when block sections were obtained for micro-computed tomography and histometric analyses. Results Total augmented volumes did not differ significantly between groups. Histometric analysis showed significantly enhanced bone formation for the BMP-2 groups compared with control. Conclusion BMP-2 in a BHC carrier, even at the low 0.1-mg/ml concentration, induces osteogenic activity, enhancing local bone formation in a canine sinus model.

Original languageEnglish
Pages (from-to)86-93
Number of pages8
JournalJournal of Clinical Periodontology
Volume41
Issue number1
DOIs
Publication statusPublished - 2014 Jan 1

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Bone Morphogenetic Protein 2
Durapatite
Collagen
Dogs
Osteogenesis
Canidae
Escherichia coli
Paranasal Sinuses
Tomography
Weights and Measures
Bone and Bones

All Science Journal Classification (ASJC) codes

  • Periodontics

Cite this

Cha, Jae Kook ; Lee, Jung Seok ; Kim, Min Soo ; Choi, Seongho ; Cho, Kyoo Sung ; Jung, Ui-Won. / Sinus augmentation using BMP-2 in a bovine hydroxyapatite/collagen carrier in dogs. In: Journal of Clinical Periodontology. 2014 ; Vol. 41, No. 1. pp. 86-93.
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Sinus augmentation using BMP-2 in a bovine hydroxyapatite/collagen carrier in dogs. / Cha, Jae Kook; Lee, Jung Seok; Kim, Min Soo; Choi, Seongho; Cho, Kyoo Sung; Jung, Ui-Won.

In: Journal of Clinical Periodontology, Vol. 41, No. 1, 01.01.2014, p. 86-93.

Research output: Contribution to journalArticle

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AB - Aim The objective of this study was to determine the efficacy of bone morphogenetic protein 2 (BMP-2) in a bovine hydroxyapatite/collagen (BHC) carrier to augment bone formation in a canine nasal sinus model. Methods Eight mongrel dogs, approximately 12 months old and 30 kg in weight were used. Following preparation of bilateral sinus access windows, BHC alone (control) or loaded with E. coli-derived BMP-2 at 0.1 mg/ml was implanted in four animals, and BHC loaded with E. coli-derived BMP-2 at 0.5 and 1.5 mg/ml was implanted in four animals. The animals were euthanized at 20 weeks when block sections were obtained for micro-computed tomography and histometric analyses. Results Total augmented volumes did not differ significantly between groups. Histometric analysis showed significantly enhanced bone formation for the BMP-2 groups compared with control. Conclusion BMP-2 in a BHC carrier, even at the low 0.1-mg/ml concentration, induces osteogenic activity, enhancing local bone formation in a canine sinus model.

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