Sinus augmentation using rhBMP-2-loaded synthetic bone substitute with simultaneous implant placement in rabbits

Myung Jae Joo, Jae Kook Cha, Hyun Chang Lim, Seong Ho Choi, Ui Won Jung

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Purpose: The aim of this study was to determine the effect of recombinant human bone morphogenetic protein-2 (rhBMP-2)-loaded synthetic bone substitute on implants that were simultaneously placed with sinus augmentation in rabbits. Methods: In this study, a circular access window was prepared in the maxillary sinus of rabbits (n=5) for a bone graft around an implant (Ø 3×6 mm) that was simultaneously placed anterior to the window. Synthetic bone substitute loaded with rhBMP-2 was placed on one side of the sinus to form the experimental group, and saline-soaked synthetic bone substitute was placed on the other side of the sinus to form the control group. After 4 weeks, sections were obtained for analysis by micro-computed tomography and histology. Results: Volumetric analysis showed that the median amount of newly formed bone was significantly greater in the BMP group than in the control group (51.6 mm3 and 46.6 mm3, respectively; P=0.019). In the histometric analysis, the osseointegration height was also significantly greater in the BMP group at the medial surface of the implant (5.2 mm and 4.3 mm, respectively; P=0.037). Conclusions: In conclusion, an implant simultaneously placed with sinus augmentation using rhBMP-2-loaded synthetic bone substitute can be successfully osseointegrated, even when only a limited bone height is available during the early stage of healing.

Original languageEnglish
Pages (from-to)86-95
Number of pages10
JournalJournal of Periodontal and Implant Science
Volume47
Issue number2
DOIs
Publication statusPublished - 2017 Apr 1

Fingerprint

Bone Substitutes
Rabbits
Bone and Bones
Osseointegration
Control Groups
Maxillary Sinus
Histology
Tomography
Transplants
recombinant human bone morphogenetic protein-2

All Science Journal Classification (ASJC) codes

  • Oral Surgery
  • Periodontics

Cite this

@article{cd5884cf32ea4cef81f6c56f36f7e0c9,
title = "Sinus augmentation using rhBMP-2-loaded synthetic bone substitute with simultaneous implant placement in rabbits",
abstract = "Purpose: The aim of this study was to determine the effect of recombinant human bone morphogenetic protein-2 (rhBMP-2)-loaded synthetic bone substitute on implants that were simultaneously placed with sinus augmentation in rabbits. Methods: In this study, a circular access window was prepared in the maxillary sinus of rabbits (n=5) for a bone graft around an implant ({\O} 3×6 mm) that was simultaneously placed anterior to the window. Synthetic bone substitute loaded with rhBMP-2 was placed on one side of the sinus to form the experimental group, and saline-soaked synthetic bone substitute was placed on the other side of the sinus to form the control group. After 4 weeks, sections were obtained for analysis by micro-computed tomography and histology. Results: Volumetric analysis showed that the median amount of newly formed bone was significantly greater in the BMP group than in the control group (51.6 mm3 and 46.6 mm3, respectively; P=0.019). In the histometric analysis, the osseointegration height was also significantly greater in the BMP group at the medial surface of the implant (5.2 mm and 4.3 mm, respectively; P=0.037). Conclusions: In conclusion, an implant simultaneously placed with sinus augmentation using rhBMP-2-loaded synthetic bone substitute can be successfully osseointegrated, even when only a limited bone height is available during the early stage of healing.",
author = "Joo, {Myung Jae} and Cha, {Jae Kook} and Lim, {Hyun Chang} and Choi, {Seong Ho} and Jung, {Ui Won}",
year = "2017",
month = "4",
day = "1",
doi = "10.5051/jpis.2017.47.2.86",
language = "English",
volume = "47",
pages = "86--95",
journal = "Journal of Periodontal and Implant Science",
issn = "2093-2278",
publisher = "Korean Academy of Periodontology",
number = "2",

}

Sinus augmentation using rhBMP-2-loaded synthetic bone substitute with simultaneous implant placement in rabbits. / Joo, Myung Jae; Cha, Jae Kook; Lim, Hyun Chang; Choi, Seong Ho; Jung, Ui Won.

In: Journal of Periodontal and Implant Science, Vol. 47, No. 2, 01.04.2017, p. 86-95.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Sinus augmentation using rhBMP-2-loaded synthetic bone substitute with simultaneous implant placement in rabbits

AU - Joo, Myung Jae

AU - Cha, Jae Kook

AU - Lim, Hyun Chang

AU - Choi, Seong Ho

AU - Jung, Ui Won

PY - 2017/4/1

Y1 - 2017/4/1

N2 - Purpose: The aim of this study was to determine the effect of recombinant human bone morphogenetic protein-2 (rhBMP-2)-loaded synthetic bone substitute on implants that were simultaneously placed with sinus augmentation in rabbits. Methods: In this study, a circular access window was prepared in the maxillary sinus of rabbits (n=5) for a bone graft around an implant (Ø 3×6 mm) that was simultaneously placed anterior to the window. Synthetic bone substitute loaded with rhBMP-2 was placed on one side of the sinus to form the experimental group, and saline-soaked synthetic bone substitute was placed on the other side of the sinus to form the control group. After 4 weeks, sections were obtained for analysis by micro-computed tomography and histology. Results: Volumetric analysis showed that the median amount of newly formed bone was significantly greater in the BMP group than in the control group (51.6 mm3 and 46.6 mm3, respectively; P=0.019). In the histometric analysis, the osseointegration height was also significantly greater in the BMP group at the medial surface of the implant (5.2 mm and 4.3 mm, respectively; P=0.037). Conclusions: In conclusion, an implant simultaneously placed with sinus augmentation using rhBMP-2-loaded synthetic bone substitute can be successfully osseointegrated, even when only a limited bone height is available during the early stage of healing.

AB - Purpose: The aim of this study was to determine the effect of recombinant human bone morphogenetic protein-2 (rhBMP-2)-loaded synthetic bone substitute on implants that were simultaneously placed with sinus augmentation in rabbits. Methods: In this study, a circular access window was prepared in the maxillary sinus of rabbits (n=5) for a bone graft around an implant (Ø 3×6 mm) that was simultaneously placed anterior to the window. Synthetic bone substitute loaded with rhBMP-2 was placed on one side of the sinus to form the experimental group, and saline-soaked synthetic bone substitute was placed on the other side of the sinus to form the control group. After 4 weeks, sections were obtained for analysis by micro-computed tomography and histology. Results: Volumetric analysis showed that the median amount of newly formed bone was significantly greater in the BMP group than in the control group (51.6 mm3 and 46.6 mm3, respectively; P=0.019). In the histometric analysis, the osseointegration height was also significantly greater in the BMP group at the medial surface of the implant (5.2 mm and 4.3 mm, respectively; P=0.037). Conclusions: In conclusion, an implant simultaneously placed with sinus augmentation using rhBMP-2-loaded synthetic bone substitute can be successfully osseointegrated, even when only a limited bone height is available during the early stage of healing.

UR - http://www.scopus.com/inward/record.url?scp=85019003846&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85019003846&partnerID=8YFLogxK

U2 - 10.5051/jpis.2017.47.2.86

DO - 10.5051/jpis.2017.47.2.86

M3 - Article

AN - SCOPUS:85019003846

VL - 47

SP - 86

EP - 95

JO - Journal of Periodontal and Implant Science

JF - Journal of Periodontal and Implant Science

SN - 2093-2278

IS - 2

ER -