Abstract
Purpose: The aim of this study was to determine the effect of recombinant human bone morphogenetic protein-2 (rhBMP-2)-loaded synthetic bone substitute on implants that were simultaneously placed with sinus augmentation in rabbits.Methods: In this study, a circular access window was prepared in the maxillary sinus of rabbits (n=5) for a bone graft around an implant (Ø 3×6 mm) that was simultaneously placed anterior to the window. Synthetic bone substitute loaded with rhBMP-2 was placed on one side of the sinus to form the experimental group, and saline-soaked synthetic bone substitute was placed on the other side of the sinus to form the control group. After 4 weeks, sections were obtained for analysis by micro-computed tomography and histology.Results: Volumetric analysis showed that the median amount of newly formed bone was significantly greater in the BMP group than in the control group (51.6 mm3 and 46.6 mm3, respectively; P=0.019). In the histometric analysis, the osseointegration height was also significantly greater in the BMP group at the medial surface of the implant (5.2 mm and 4.3 mm, respectively; P=0.037).Conclusions:
Original language | English |
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Pages (from-to) | 86-95 |
Number of pages | 10 |
Journal | Journal of Periodontal and Implant Science |
Volume | 47 |
Issue number | 2 |
DOIs | |
Publication status | Published - 2017 Apr |
Bibliographical note
Funding Information:This study was supported by a faculty research grant of Yonsei University College of Dentistry for 2016 (6-2016-0028).
Publisher Copyright:
© 2017. Korean Academy of Periodontology
All Science Journal Classification (ASJC) codes
- Oral Surgery
- Periodontics