Sinus floor elevation in sites with a perforated schneiderian membrane

What is the effect of placing a collagen membrane in a rabbit model?

Hyun Chang Lim, Yeojin Son, Ji Youn Hong, Seung Il Shin, Ui-Won Jung, Jong Hyuk Chung

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Objective: To investigate the healing following sinus grafting in sites with a perforated schneiderian membrane repaired using a collagen membrane, compared to control sites without membrane perforation. Materials & Methods: Following elevation of the sinus membrane in 16 rabbits, each sinus was assigned to one of the following groups: (a) intentional schneiderian membrane perforation, followed by the placement of a collagen membrane and bone grafting (group SMP) and (b) bone grafting without a perforation of the schneiderian membrane and without a collagen membrane placement (control group). At 2 and 4 weeks (n = 8 for each time-point), microcomputed tomographic (micro-CT) and histomorphometric analyses were performed. Results: Overall new bone formation in group SMP was significantly delayed compared to the control group at 2 and 4 weeks (1.58 ± 1.25% vs. 9.23 ± 2.69% at 2 weeks, 10.43 ± 3.55 vs. 17.86 ± 4.11% at 4 weeks, p < 0.05). At 2 weeks, new bone formation for the areas close to lateral (1.19 ± 2.02%) and medial sinus bone walls (3.17 ± 1.98%) was markedly delayed in group SMP compared to the control group (13.08 ± 6.13% and 12.75 ± 5.63%, respectively, p < 0.05), but there was no statistical difference in those areas at 4 weeks (p > 0.05). The augmented volumes at 2 and 4 weeks were not statistically significantly different in both groups. Conclusion: The perforation of the schneiderian membrane and the repair using a collagen membrane delayed new bone formation in the augmented sinuses. However, the extension of the collagen membrane on the sinus bone walls was also attributable to this delayed bone formation.

Original languageEnglish
Pages (from-to)1202-1211
Number of pages10
JournalClinical Oral Implants Research
Volume29
Issue number12
DOIs
Publication statusPublished - 2018 Dec 1

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Nasal Mucosa
Collagen
Rabbits
Membranes
Osteogenesis
Bone Transplantation
Control Groups
Bone and Bones

All Science Journal Classification (ASJC) codes

  • Oral Surgery

Cite this

Lim, Hyun Chang ; Son, Yeojin ; Hong, Ji Youn ; Shin, Seung Il ; Jung, Ui-Won ; Chung, Jong Hyuk. / Sinus floor elevation in sites with a perforated schneiderian membrane : What is the effect of placing a collagen membrane in a rabbit model?. In: Clinical Oral Implants Research. 2018 ; Vol. 29, No. 12. pp. 1202-1211.
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title = "Sinus floor elevation in sites with a perforated schneiderian membrane: What is the effect of placing a collagen membrane in a rabbit model?",
abstract = "Objective: To investigate the healing following sinus grafting in sites with a perforated schneiderian membrane repaired using a collagen membrane, compared to control sites without membrane perforation. Materials & Methods: Following elevation of the sinus membrane in 16 rabbits, each sinus was assigned to one of the following groups: (a) intentional schneiderian membrane perforation, followed by the placement of a collagen membrane and bone grafting (group SMP) and (b) bone grafting without a perforation of the schneiderian membrane and without a collagen membrane placement (control group). At 2 and 4 weeks (n = 8 for each time-point), microcomputed tomographic (micro-CT) and histomorphometric analyses were performed. Results: Overall new bone formation in group SMP was significantly delayed compared to the control group at 2 and 4 weeks (1.58 ± 1.25{\%} vs. 9.23 ± 2.69{\%} at 2 weeks, 10.43 ± 3.55 vs. 17.86 ± 4.11{\%} at 4 weeks, p < 0.05). At 2 weeks, new bone formation for the areas close to lateral (1.19 ± 2.02{\%}) and medial sinus bone walls (3.17 ± 1.98{\%}) was markedly delayed in group SMP compared to the control group (13.08 ± 6.13{\%} and 12.75 ± 5.63{\%}, respectively, p < 0.05), but there was no statistical difference in those areas at 4 weeks (p > 0.05). The augmented volumes at 2 and 4 weeks were not statistically significantly different in both groups. Conclusion: The perforation of the schneiderian membrane and the repair using a collagen membrane delayed new bone formation in the augmented sinuses. However, the extension of the collagen membrane on the sinus bone walls was also attributable to this delayed bone formation.",
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Sinus floor elevation in sites with a perforated schneiderian membrane : What is the effect of placing a collagen membrane in a rabbit model? / Lim, Hyun Chang; Son, Yeojin; Hong, Ji Youn; Shin, Seung Il; Jung, Ui-Won; Chung, Jong Hyuk.

In: Clinical Oral Implants Research, Vol. 29, No. 12, 01.12.2018, p. 1202-1211.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Sinus floor elevation in sites with a perforated schneiderian membrane

T2 - What is the effect of placing a collagen membrane in a rabbit model?

AU - Lim, Hyun Chang

AU - Son, Yeojin

AU - Hong, Ji Youn

AU - Shin, Seung Il

AU - Jung, Ui-Won

AU - Chung, Jong Hyuk

PY - 2018/12/1

Y1 - 2018/12/1

N2 - Objective: To investigate the healing following sinus grafting in sites with a perforated schneiderian membrane repaired using a collagen membrane, compared to control sites without membrane perforation. Materials & Methods: Following elevation of the sinus membrane in 16 rabbits, each sinus was assigned to one of the following groups: (a) intentional schneiderian membrane perforation, followed by the placement of a collagen membrane and bone grafting (group SMP) and (b) bone grafting without a perforation of the schneiderian membrane and without a collagen membrane placement (control group). At 2 and 4 weeks (n = 8 for each time-point), microcomputed tomographic (micro-CT) and histomorphometric analyses were performed. Results: Overall new bone formation in group SMP was significantly delayed compared to the control group at 2 and 4 weeks (1.58 ± 1.25% vs. 9.23 ± 2.69% at 2 weeks, 10.43 ± 3.55 vs. 17.86 ± 4.11% at 4 weeks, p < 0.05). At 2 weeks, new bone formation for the areas close to lateral (1.19 ± 2.02%) and medial sinus bone walls (3.17 ± 1.98%) was markedly delayed in group SMP compared to the control group (13.08 ± 6.13% and 12.75 ± 5.63%, respectively, p < 0.05), but there was no statistical difference in those areas at 4 weeks (p > 0.05). The augmented volumes at 2 and 4 weeks were not statistically significantly different in both groups. Conclusion: The perforation of the schneiderian membrane and the repair using a collagen membrane delayed new bone formation in the augmented sinuses. However, the extension of the collagen membrane on the sinus bone walls was also attributable to this delayed bone formation.

AB - Objective: To investigate the healing following sinus grafting in sites with a perforated schneiderian membrane repaired using a collagen membrane, compared to control sites without membrane perforation. Materials & Methods: Following elevation of the sinus membrane in 16 rabbits, each sinus was assigned to one of the following groups: (a) intentional schneiderian membrane perforation, followed by the placement of a collagen membrane and bone grafting (group SMP) and (b) bone grafting without a perforation of the schneiderian membrane and without a collagen membrane placement (control group). At 2 and 4 weeks (n = 8 for each time-point), microcomputed tomographic (micro-CT) and histomorphometric analyses were performed. Results: Overall new bone formation in group SMP was significantly delayed compared to the control group at 2 and 4 weeks (1.58 ± 1.25% vs. 9.23 ± 2.69% at 2 weeks, 10.43 ± 3.55 vs. 17.86 ± 4.11% at 4 weeks, p < 0.05). At 2 weeks, new bone formation for the areas close to lateral (1.19 ± 2.02%) and medial sinus bone walls (3.17 ± 1.98%) was markedly delayed in group SMP compared to the control group (13.08 ± 6.13% and 12.75 ± 5.63%, respectively, p < 0.05), but there was no statistical difference in those areas at 4 weeks (p > 0.05). The augmented volumes at 2 and 4 weeks were not statistically significantly different in both groups. Conclusion: The perforation of the schneiderian membrane and the repair using a collagen membrane delayed new bone formation in the augmented sinuses. However, the extension of the collagen membrane on the sinus bone walls was also attributable to this delayed bone formation.

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