Sirolimus-eluting stent implantation for treatment of proximal left anterior descending coronary artery lesions

Long-term outcome and predictors of adverse cardiac events

Whan Lee Cheol, Chong Hiok Tan, Jon Suh, Se Whan Lee, Duk Woo Park, Seung Whan Lee, Young Hak Kim, Myeongki Hong, Jae Joong Kim, Seong Wook Park, Seung Jung Park

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Objectives: Acute and long-term results after sirolimus-eluting stent (SES) implantation of proximal left anterior descending coronary artery (LAD) disease were evaluated. Background: Although SES has been used increasingly for the treatment of LAD disease, data regarding their safety and efficacy in a real-world population are limited. Methods: We investigate the short- and long-term results in 966 patients who underwent SES implantation for stenosis of proximal LAD. Results: The procedural success rate was 97.6%, and procedural non-Q-wave myocardial infarction (MI) rate was 14.5%. In-hospital major complications occurred in five patients (0.5%), including three deaths and two Q-wave MIs. During follow-up (20.4 ± 8.9 months), there were 16 deaths (1.7%; 10 cardiac, 6 noncardiac), 2 Q-wave MIs, and 22 target lesion revascularizations (2.3%). Late stent thrombosis occurred in two patients (0.2%), 14 and 23 months after the procedure. The event-free survival rates for cardiac death/Q-wave MI were 98.6% ± 0.4% at 1 year and 97.8% ± 0.6% at 2 years. The cumulative probabilities of survival without major adverse cardiac events (MACE) were 96.7% ± 0.6% at 1 year and 95.4% ± 0.8% at 2 years. In multivariate analysis, stented length (HR 1.04, 95%CI 1.01-1.07, P = 0.009) and infarct-related artery (HR 5.18, 95%CI 1.09-24.64, P = 0.039) were independently related to cardiac death/Q-wave MI. In addition, stented length (HR 1.04, 95%CI 1.02-1.06, P < 0.001) and left ventricular dysfunction (HR 2.66, 95%CI 1.07-6.63, P = 0.036) were significant independent predictors of MACE. Conclusions: SES implantation for proximal LAD disease appears safe and effective in a real-world population, and the independent predictors of MACE included stented length and left ventricular dysfunction.

Original languageEnglish
Pages (from-to)368-373
Number of pages6
JournalCatheterization and Cardiovascular Interventions
Volume70
Issue number3
DOIs
Publication statusPublished - 2007 Sep 1

Fingerprint

Sirolimus
Stents
Coronary Vessels
Myocardial Infarction
Left Ventricular Dysfunction
Therapeutics
Population
Disease-Free Survival
Coronary Artery Disease
Pathologic Constriction
Thrombosis
Multivariate Analysis
Survival Rate
Arteries
Safety
Survival

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

Cite this

Cheol, Whan Lee ; Tan, Chong Hiok ; Suh, Jon ; Lee, Se Whan ; Park, Duk Woo ; Lee, Seung Whan ; Kim, Young Hak ; Hong, Myeongki ; Kim, Jae Joong ; Park, Seong Wook ; Park, Seung Jung. / Sirolimus-eluting stent implantation for treatment of proximal left anterior descending coronary artery lesions : Long-term outcome and predictors of adverse cardiac events. In: Catheterization and Cardiovascular Interventions. 2007 ; Vol. 70, No. 3. pp. 368-373.
@article{8842ccac7ef548c9ac5d15e721fc20f7,
title = "Sirolimus-eluting stent implantation for treatment of proximal left anterior descending coronary artery lesions: Long-term outcome and predictors of adverse cardiac events",
abstract = "Objectives: Acute and long-term results after sirolimus-eluting stent (SES) implantation of proximal left anterior descending coronary artery (LAD) disease were evaluated. Background: Although SES has been used increasingly for the treatment of LAD disease, data regarding their safety and efficacy in a real-world population are limited. Methods: We investigate the short- and long-term results in 966 patients who underwent SES implantation for stenosis of proximal LAD. Results: The procedural success rate was 97.6{\%}, and procedural non-Q-wave myocardial infarction (MI) rate was 14.5{\%}. In-hospital major complications occurred in five patients (0.5{\%}), including three deaths and two Q-wave MIs. During follow-up (20.4 ± 8.9 months), there were 16 deaths (1.7{\%}; 10 cardiac, 6 noncardiac), 2 Q-wave MIs, and 22 target lesion revascularizations (2.3{\%}). Late stent thrombosis occurred in two patients (0.2{\%}), 14 and 23 months after the procedure. The event-free survival rates for cardiac death/Q-wave MI were 98.6{\%} ± 0.4{\%} at 1 year and 97.8{\%} ± 0.6{\%} at 2 years. The cumulative probabilities of survival without major adverse cardiac events (MACE) were 96.7{\%} ± 0.6{\%} at 1 year and 95.4{\%} ± 0.8{\%} at 2 years. In multivariate analysis, stented length (HR 1.04, 95{\%}CI 1.01-1.07, P = 0.009) and infarct-related artery (HR 5.18, 95{\%}CI 1.09-24.64, P = 0.039) were independently related to cardiac death/Q-wave MI. In addition, stented length (HR 1.04, 95{\%}CI 1.02-1.06, P < 0.001) and left ventricular dysfunction (HR 2.66, 95{\%}CI 1.07-6.63, P = 0.036) were significant independent predictors of MACE. Conclusions: SES implantation for proximal LAD disease appears safe and effective in a real-world population, and the independent predictors of MACE included stented length and left ventricular dysfunction.",
author = "Cheol, {Whan Lee} and Tan, {Chong Hiok} and Jon Suh and Lee, {Se Whan} and Park, {Duk Woo} and Lee, {Seung Whan} and Kim, {Young Hak} and Myeongki Hong and Kim, {Jae Joong} and Park, {Seong Wook} and Park, {Seung Jung}",
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Sirolimus-eluting stent implantation for treatment of proximal left anterior descending coronary artery lesions : Long-term outcome and predictors of adverse cardiac events. / Cheol, Whan Lee; Tan, Chong Hiok; Suh, Jon; Lee, Se Whan; Park, Duk Woo; Lee, Seung Whan; Kim, Young Hak; Hong, Myeongki; Kim, Jae Joong; Park, Seong Wook; Park, Seung Jung.

In: Catheterization and Cardiovascular Interventions, Vol. 70, No. 3, 01.09.2007, p. 368-373.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Sirolimus-eluting stent implantation for treatment of proximal left anterior descending coronary artery lesions

T2 - Long-term outcome and predictors of adverse cardiac events

AU - Cheol, Whan Lee

AU - Tan, Chong Hiok

AU - Suh, Jon

AU - Lee, Se Whan

AU - Park, Duk Woo

AU - Lee, Seung Whan

AU - Kim, Young Hak

AU - Hong, Myeongki

AU - Kim, Jae Joong

AU - Park, Seong Wook

AU - Park, Seung Jung

PY - 2007/9/1

Y1 - 2007/9/1

N2 - Objectives: Acute and long-term results after sirolimus-eluting stent (SES) implantation of proximal left anterior descending coronary artery (LAD) disease were evaluated. Background: Although SES has been used increasingly for the treatment of LAD disease, data regarding their safety and efficacy in a real-world population are limited. Methods: We investigate the short- and long-term results in 966 patients who underwent SES implantation for stenosis of proximal LAD. Results: The procedural success rate was 97.6%, and procedural non-Q-wave myocardial infarction (MI) rate was 14.5%. In-hospital major complications occurred in five patients (0.5%), including three deaths and two Q-wave MIs. During follow-up (20.4 ± 8.9 months), there were 16 deaths (1.7%; 10 cardiac, 6 noncardiac), 2 Q-wave MIs, and 22 target lesion revascularizations (2.3%). Late stent thrombosis occurred in two patients (0.2%), 14 and 23 months after the procedure. The event-free survival rates for cardiac death/Q-wave MI were 98.6% ± 0.4% at 1 year and 97.8% ± 0.6% at 2 years. The cumulative probabilities of survival without major adverse cardiac events (MACE) were 96.7% ± 0.6% at 1 year and 95.4% ± 0.8% at 2 years. In multivariate analysis, stented length (HR 1.04, 95%CI 1.01-1.07, P = 0.009) and infarct-related artery (HR 5.18, 95%CI 1.09-24.64, P = 0.039) were independently related to cardiac death/Q-wave MI. In addition, stented length (HR 1.04, 95%CI 1.02-1.06, P < 0.001) and left ventricular dysfunction (HR 2.66, 95%CI 1.07-6.63, P = 0.036) were significant independent predictors of MACE. Conclusions: SES implantation for proximal LAD disease appears safe and effective in a real-world population, and the independent predictors of MACE included stented length and left ventricular dysfunction.

AB - Objectives: Acute and long-term results after sirolimus-eluting stent (SES) implantation of proximal left anterior descending coronary artery (LAD) disease were evaluated. Background: Although SES has been used increasingly for the treatment of LAD disease, data regarding their safety and efficacy in a real-world population are limited. Methods: We investigate the short- and long-term results in 966 patients who underwent SES implantation for stenosis of proximal LAD. Results: The procedural success rate was 97.6%, and procedural non-Q-wave myocardial infarction (MI) rate was 14.5%. In-hospital major complications occurred in five patients (0.5%), including three deaths and two Q-wave MIs. During follow-up (20.4 ± 8.9 months), there were 16 deaths (1.7%; 10 cardiac, 6 noncardiac), 2 Q-wave MIs, and 22 target lesion revascularizations (2.3%). Late stent thrombosis occurred in two patients (0.2%), 14 and 23 months after the procedure. The event-free survival rates for cardiac death/Q-wave MI were 98.6% ± 0.4% at 1 year and 97.8% ± 0.6% at 2 years. The cumulative probabilities of survival without major adverse cardiac events (MACE) were 96.7% ± 0.6% at 1 year and 95.4% ± 0.8% at 2 years. In multivariate analysis, stented length (HR 1.04, 95%CI 1.01-1.07, P = 0.009) and infarct-related artery (HR 5.18, 95%CI 1.09-24.64, P = 0.039) were independently related to cardiac death/Q-wave MI. In addition, stented length (HR 1.04, 95%CI 1.02-1.06, P < 0.001) and left ventricular dysfunction (HR 2.66, 95%CI 1.07-6.63, P = 0.036) were significant independent predictors of MACE. Conclusions: SES implantation for proximal LAD disease appears safe and effective in a real-world population, and the independent predictors of MACE included stented length and left ventricular dysfunction.

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