Sirolimus-eluting stent versus paclitaxel-eluting stent for patients with long coronary artery disease

Young Hak Kim, Seong Wook Park, Seung Whan Lee, Duk Woo Park, Sung Cheol Yun, Cheol Whan Lee, Myeongki Hong, Hyun Sook Kim, Jae Ki Ko, Jae Hyeong Park, Jae Hwan Lee, Si Wan Choi, In Whan Seong, Yoon Haeng Cho, Nae Hee Lee, June Hong Kim, Kook Jin Chun, Seung Jung Park

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Abstract

BACKGROUND - Outcomes remain relatively unfavorable for stent-based coronary intervention of lesions with long diseased segments. This study compared sirolimus-eluting stents (SES) and paclitaxel-eluting stents (PES) for long coronary lesions. METHODS AND RESULTS - The present randomized, multicenter, prospective study compared the use of long (≥32 mm) SES with PES in 500 patients with long (≥25 mm) native coronary lesions. The primary end point of the trial was the rate of binary in-segment restenosis according to follow-up angiography at 6 months. The SES and PES groups had similar baseline characteristics. Lesion length was 33.9±11.6 mm in the SES group and 34.5±12.6 mm in the PES group (P=0.527). The in-segment binary restenosis rate was significantly lower in the SES group than in the PES group (3.3% versus 14.6%; relative risk 0.23; P<0.001). In-stent late loss of lumen diameter was 0.09±0.37 mm in the SES group and 0.45±0.55 mm in the PES group (P<0.001). In patients with restenoses, a pattern of focal restenosis was more common in the SES group than in the PES group (100% versus 53.3%, P=0.031). Consequently, SES patients had a lower rate of target-lesion revascularization at 9 months (2.4% versus 7.2%, P=0.012). The incidence of death (0.8% in SES versus 0% in PES, P=0.499) or myocardial infarction (8.8% in SES versus 10.8% in PES, P=0.452) at 9 months of follow-up was not statistically different between the 2 groups. CONCLUSIONS - For patients with long native coronary artery disease, SES implantation was associated with a reduced incidence of angiographic restenosis and a reduced need for target-lesion revascularization compared with PES implantation.

Original languageEnglish
Pages (from-to)2148-2153
Number of pages6
JournalCirculation
Volume114
Issue number20
DOIs
Publication statusPublished - 2006 Nov 1

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Sirolimus
Paclitaxel
Stents
Coronary Artery Disease

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Cite this

Kim, Y. H., Park, S. W., Lee, S. W., Park, D. W., Yun, S. C., Lee, C. W., ... Park, S. J. (2006). Sirolimus-eluting stent versus paclitaxel-eluting stent for patients with long coronary artery disease. Circulation, 114(20), 2148-2153. https://doi.org/10.1161/CIRCULATIONAHA.106.666396
Kim, Young Hak ; Park, Seong Wook ; Lee, Seung Whan ; Park, Duk Woo ; Yun, Sung Cheol ; Lee, Cheol Whan ; Hong, Myeongki ; Kim, Hyun Sook ; Ko, Jae Ki ; Park, Jae Hyeong ; Lee, Jae Hwan ; Choi, Si Wan ; Seong, In Whan ; Cho, Yoon Haeng ; Lee, Nae Hee ; Kim, June Hong ; Chun, Kook Jin ; Park, Seung Jung. / Sirolimus-eluting stent versus paclitaxel-eluting stent for patients with long coronary artery disease. In: Circulation. 2006 ; Vol. 114, No. 20. pp. 2148-2153.
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title = "Sirolimus-eluting stent versus paclitaxel-eluting stent for patients with long coronary artery disease",
abstract = "BACKGROUND - Outcomes remain relatively unfavorable for stent-based coronary intervention of lesions with long diseased segments. This study compared sirolimus-eluting stents (SES) and paclitaxel-eluting stents (PES) for long coronary lesions. METHODS AND RESULTS - The present randomized, multicenter, prospective study compared the use of long (≥32 mm) SES with PES in 500 patients with long (≥25 mm) native coronary lesions. The primary end point of the trial was the rate of binary in-segment restenosis according to follow-up angiography at 6 months. The SES and PES groups had similar baseline characteristics. Lesion length was 33.9±11.6 mm in the SES group and 34.5±12.6 mm in the PES group (P=0.527). The in-segment binary restenosis rate was significantly lower in the SES group than in the PES group (3.3{\%} versus 14.6{\%}; relative risk 0.23; P<0.001). In-stent late loss of lumen diameter was 0.09±0.37 mm in the SES group and 0.45±0.55 mm in the PES group (P<0.001). In patients with restenoses, a pattern of focal restenosis was more common in the SES group than in the PES group (100{\%} versus 53.3{\%}, P=0.031). Consequently, SES patients had a lower rate of target-lesion revascularization at 9 months (2.4{\%} versus 7.2{\%}, P=0.012). The incidence of death (0.8{\%} in SES versus 0{\%} in PES, P=0.499) or myocardial infarction (8.8{\%} in SES versus 10.8{\%} in PES, P=0.452) at 9 months of follow-up was not statistically different between the 2 groups. CONCLUSIONS - For patients with long native coronary artery disease, SES implantation was associated with a reduced incidence of angiographic restenosis and a reduced need for target-lesion revascularization compared with PES implantation.",
author = "Kim, {Young Hak} and Park, {Seong Wook} and Lee, {Seung Whan} and Park, {Duk Woo} and Yun, {Sung Cheol} and Lee, {Cheol Whan} and Myeongki Hong and Kim, {Hyun Sook} and Ko, {Jae Ki} and Park, {Jae Hyeong} and Lee, {Jae Hwan} and Choi, {Si Wan} and Seong, {In Whan} and Cho, {Yoon Haeng} and Lee, {Nae Hee} and Kim, {June Hong} and Chun, {Kook Jin} and Park, {Seung Jung}",
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Kim, YH, Park, SW, Lee, SW, Park, DW, Yun, SC, Lee, CW, Hong, M, Kim, HS, Ko, JK, Park, JH, Lee, JH, Choi, SW, Seong, IW, Cho, YH, Lee, NH, Kim, JH, Chun, KJ & Park, SJ 2006, 'Sirolimus-eluting stent versus paclitaxel-eluting stent for patients with long coronary artery disease', Circulation, vol. 114, no. 20, pp. 2148-2153. https://doi.org/10.1161/CIRCULATIONAHA.106.666396

Sirolimus-eluting stent versus paclitaxel-eluting stent for patients with long coronary artery disease. / Kim, Young Hak; Park, Seong Wook; Lee, Seung Whan; Park, Duk Woo; Yun, Sung Cheol; Lee, Cheol Whan; Hong, Myeongki; Kim, Hyun Sook; Ko, Jae Ki; Park, Jae Hyeong; Lee, Jae Hwan; Choi, Si Wan; Seong, In Whan; Cho, Yoon Haeng; Lee, Nae Hee; Kim, June Hong; Chun, Kook Jin; Park, Seung Jung.

In: Circulation, Vol. 114, No. 20, 01.11.2006, p. 2148-2153.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Sirolimus-eluting stent versus paclitaxel-eluting stent for patients with long coronary artery disease

AU - Kim, Young Hak

AU - Park, Seong Wook

AU - Lee, Seung Whan

AU - Park, Duk Woo

AU - Yun, Sung Cheol

AU - Lee, Cheol Whan

AU - Hong, Myeongki

AU - Kim, Hyun Sook

AU - Ko, Jae Ki

AU - Park, Jae Hyeong

AU - Lee, Jae Hwan

AU - Choi, Si Wan

AU - Seong, In Whan

AU - Cho, Yoon Haeng

AU - Lee, Nae Hee

AU - Kim, June Hong

AU - Chun, Kook Jin

AU - Park, Seung Jung

PY - 2006/11/1

Y1 - 2006/11/1

N2 - BACKGROUND - Outcomes remain relatively unfavorable for stent-based coronary intervention of lesions with long diseased segments. This study compared sirolimus-eluting stents (SES) and paclitaxel-eluting stents (PES) for long coronary lesions. METHODS AND RESULTS - The present randomized, multicenter, prospective study compared the use of long (≥32 mm) SES with PES in 500 patients with long (≥25 mm) native coronary lesions. The primary end point of the trial was the rate of binary in-segment restenosis according to follow-up angiography at 6 months. The SES and PES groups had similar baseline characteristics. Lesion length was 33.9±11.6 mm in the SES group and 34.5±12.6 mm in the PES group (P=0.527). The in-segment binary restenosis rate was significantly lower in the SES group than in the PES group (3.3% versus 14.6%; relative risk 0.23; P<0.001). In-stent late loss of lumen diameter was 0.09±0.37 mm in the SES group and 0.45±0.55 mm in the PES group (P<0.001). In patients with restenoses, a pattern of focal restenosis was more common in the SES group than in the PES group (100% versus 53.3%, P=0.031). Consequently, SES patients had a lower rate of target-lesion revascularization at 9 months (2.4% versus 7.2%, P=0.012). The incidence of death (0.8% in SES versus 0% in PES, P=0.499) or myocardial infarction (8.8% in SES versus 10.8% in PES, P=0.452) at 9 months of follow-up was not statistically different between the 2 groups. CONCLUSIONS - For patients with long native coronary artery disease, SES implantation was associated with a reduced incidence of angiographic restenosis and a reduced need for target-lesion revascularization compared with PES implantation.

AB - BACKGROUND - Outcomes remain relatively unfavorable for stent-based coronary intervention of lesions with long diseased segments. This study compared sirolimus-eluting stents (SES) and paclitaxel-eluting stents (PES) for long coronary lesions. METHODS AND RESULTS - The present randomized, multicenter, prospective study compared the use of long (≥32 mm) SES with PES in 500 patients with long (≥25 mm) native coronary lesions. The primary end point of the trial was the rate of binary in-segment restenosis according to follow-up angiography at 6 months. The SES and PES groups had similar baseline characteristics. Lesion length was 33.9±11.6 mm in the SES group and 34.5±12.6 mm in the PES group (P=0.527). The in-segment binary restenosis rate was significantly lower in the SES group than in the PES group (3.3% versus 14.6%; relative risk 0.23; P<0.001). In-stent late loss of lumen diameter was 0.09±0.37 mm in the SES group and 0.45±0.55 mm in the PES group (P<0.001). In patients with restenoses, a pattern of focal restenosis was more common in the SES group than in the PES group (100% versus 53.3%, P=0.031). Consequently, SES patients had a lower rate of target-lesion revascularization at 9 months (2.4% versus 7.2%, P=0.012). The incidence of death (0.8% in SES versus 0% in PES, P=0.499) or myocardial infarction (8.8% in SES versus 10.8% in PES, P=0.452) at 9 months of follow-up was not statistically different between the 2 groups. CONCLUSIONS - For patients with long native coronary artery disease, SES implantation was associated with a reduced incidence of angiographic restenosis and a reduced need for target-lesion revascularization compared with PES implantation.

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