Size characterization of core-shell poly(l-lactide) microspheres by flow/hyperlayer field-flow fractionation

Myeong Hee Moon, Keummi Kim, Youngro Byun, Dongjin Pyo

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Flow/hyperlayer field flow fractionation (Fl/Hy FFF) has been applied for the rapid separation and size characterization of core-shell type poly(l- lactide) (PLLA) microspheres which are widely studied as a potential drug carrier due to its biodegradability. Examined microspheres are prepared by varying the entrapped amount of the retinoic acid as an anti-cancer therapeutic and varying PEG-PLLA copolymers. It is demonstrated that the separation of PLLA microspheres can be achieved within 5 min. by Fl/Hy FFF and the particle size distribution (PSD) is readily obtained from the experimental fractograms. From the size distribution of PLLA particles obtained by Fl/Fl FFF, it is shown that PSD increases with the amount of drug loaded but it does not seriously change with the addition of PEG-PLLA copolymers.

Original languageEnglish
Pages (from-to)2729-2740
Number of pages12
JournalJournal of Liquid Chromatography and Related Technologies
Volume22
Issue number18
DOIs
Publication statusPublished - 1999 Jan 1

Fingerprint

Field Flow Fractionation
Fractionation
Microspheres
Flow fields
Particle Size
Particle size analysis
Polyethylene glycols
Copolymers
Drug Carriers
Biodegradability
Tretinoin
dilactide
poly(lactide)
Pharmaceutical Preparations
Neoplasms

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Biochemistry
  • Pharmaceutical Science
  • Clinical Biochemistry

Cite this

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abstract = "Flow/hyperlayer field flow fractionation (Fl/Hy FFF) has been applied for the rapid separation and size characterization of core-shell type poly(l- lactide) (PLLA) microspheres which are widely studied as a potential drug carrier due to its biodegradability. Examined microspheres are prepared by varying the entrapped amount of the retinoic acid as an anti-cancer therapeutic and varying PEG-PLLA copolymers. It is demonstrated that the separation of PLLA microspheres can be achieved within 5 min. by Fl/Hy FFF and the particle size distribution (PSD) is readily obtained from the experimental fractograms. From the size distribution of PLLA particles obtained by Fl/Fl FFF, it is shown that PSD increases with the amount of drug loaded but it does not seriously change with the addition of PEG-PLLA copolymers.",
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Size characterization of core-shell poly(l-lactide) microspheres by flow/hyperlayer field-flow fractionation. / Moon, Myeong Hee; Kim, Keummi; Byun, Youngro; Pyo, Dongjin.

In: Journal of Liquid Chromatography and Related Technologies, Vol. 22, No. 18, 01.01.1999, p. 2729-2740.

Research output: Contribution to journalArticle

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