Size control of chitosan capsules containing insulin for oral drug delivery via a combined process of ionic gelation with electrohydrodynamic atomization

Sang Yoon Kim, Hyunah Lee, Sungyeon Cho, Ji Woon Park, Jiyong Park, Jungho Hwang

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Recently, the development of new insulin delivery strategies, such as oral drug delivery, has sparked the interest of many researchers. In this paper, microsized chitosan capsules containing insulin were produced via a combined process of ionic gelation with electrohydrodynamic atomization (EHDA). Produced airborne chitosan-insulin droplets were reacted with phytic acid to induce the binding between chitosan and phytic acid, resulting in chitosan capsules containing insulin. As the nozzle size decreased, the size and uniformity of the primary airborne droplets decreased and enhanced, respectively. The size of primary airborne droplets affected the uniformity of the chitosan capsules in size. Using a nozzle of 320 μm in diameter, the mean diameter of the capsules was 232 μm, which is much smaller than that of capsules formed using only the ionic gelation method. The insulin encapsulation efficiency was nearly independent of nozzle size and was above 92%. Through in vitro tests, when a nozzle smaller than or equal to about 700 μm was used, the sustained insulin release occurred in the artificial intestinal juice although the smaller capsules exhibited lower resistance to acidic conditions.

Original languageEnglish
Pages (from-to)13762-13770
Number of pages9
JournalIndustrial and Engineering Chemistry Research
Volume50
Issue number24
DOIs
Publication statusPublished - 2011 Dec 21

Fingerprint

Electrohydrodynamics
Insulin
Chitosan
Atomization
Gelation
Drug delivery
Capsules
Nozzles
Phytic Acid
Acids
Encapsulation

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Chemical Engineering(all)
  • Industrial and Manufacturing Engineering

Cite this

@article{ad1316ff3e834200b0daa1e9922035a7,
title = "Size control of chitosan capsules containing insulin for oral drug delivery via a combined process of ionic gelation with electrohydrodynamic atomization",
abstract = "Recently, the development of new insulin delivery strategies, such as oral drug delivery, has sparked the interest of many researchers. In this paper, microsized chitosan capsules containing insulin were produced via a combined process of ionic gelation with electrohydrodynamic atomization (EHDA). Produced airborne chitosan-insulin droplets were reacted with phytic acid to induce the binding between chitosan and phytic acid, resulting in chitosan capsules containing insulin. As the nozzle size decreased, the size and uniformity of the primary airborne droplets decreased and enhanced, respectively. The size of primary airborne droplets affected the uniformity of the chitosan capsules in size. Using a nozzle of 320 μm in diameter, the mean diameter of the capsules was 232 μm, which is much smaller than that of capsules formed using only the ionic gelation method. The insulin encapsulation efficiency was nearly independent of nozzle size and was above 92{\%}. Through in vitro tests, when a nozzle smaller than or equal to about 700 μm was used, the sustained insulin release occurred in the artificial intestinal juice although the smaller capsules exhibited lower resistance to acidic conditions.",
author = "Kim, {Sang Yoon} and Hyunah Lee and Sungyeon Cho and Park, {Ji Woon} and Jiyong Park and Jungho Hwang",
year = "2011",
month = "12",
day = "21",
doi = "10.1021/ie200915x",
language = "English",
volume = "50",
pages = "13762--13770",
journal = "Industrial & Engineering Chemistry Product Research and Development",
issn = "0888-5885",
publisher = "American Chemical Society",
number = "24",

}

Size control of chitosan capsules containing insulin for oral drug delivery via a combined process of ionic gelation with electrohydrodynamic atomization. / Kim, Sang Yoon; Lee, Hyunah; Cho, Sungyeon; Park, Ji Woon; Park, Jiyong; Hwang, Jungho.

In: Industrial and Engineering Chemistry Research, Vol. 50, No. 24, 21.12.2011, p. 13762-13770.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Size control of chitosan capsules containing insulin for oral drug delivery via a combined process of ionic gelation with electrohydrodynamic atomization

AU - Kim, Sang Yoon

AU - Lee, Hyunah

AU - Cho, Sungyeon

AU - Park, Ji Woon

AU - Park, Jiyong

AU - Hwang, Jungho

PY - 2011/12/21

Y1 - 2011/12/21

N2 - Recently, the development of new insulin delivery strategies, such as oral drug delivery, has sparked the interest of many researchers. In this paper, microsized chitosan capsules containing insulin were produced via a combined process of ionic gelation with electrohydrodynamic atomization (EHDA). Produced airborne chitosan-insulin droplets were reacted with phytic acid to induce the binding between chitosan and phytic acid, resulting in chitosan capsules containing insulin. As the nozzle size decreased, the size and uniformity of the primary airborne droplets decreased and enhanced, respectively. The size of primary airborne droplets affected the uniformity of the chitosan capsules in size. Using a nozzle of 320 μm in diameter, the mean diameter of the capsules was 232 μm, which is much smaller than that of capsules formed using only the ionic gelation method. The insulin encapsulation efficiency was nearly independent of nozzle size and was above 92%. Through in vitro tests, when a nozzle smaller than or equal to about 700 μm was used, the sustained insulin release occurred in the artificial intestinal juice although the smaller capsules exhibited lower resistance to acidic conditions.

AB - Recently, the development of new insulin delivery strategies, such as oral drug delivery, has sparked the interest of many researchers. In this paper, microsized chitosan capsules containing insulin were produced via a combined process of ionic gelation with electrohydrodynamic atomization (EHDA). Produced airborne chitosan-insulin droplets were reacted with phytic acid to induce the binding between chitosan and phytic acid, resulting in chitosan capsules containing insulin. As the nozzle size decreased, the size and uniformity of the primary airborne droplets decreased and enhanced, respectively. The size of primary airborne droplets affected the uniformity of the chitosan capsules in size. Using a nozzle of 320 μm in diameter, the mean diameter of the capsules was 232 μm, which is much smaller than that of capsules formed using only the ionic gelation method. The insulin encapsulation efficiency was nearly independent of nozzle size and was above 92%. Through in vitro tests, when a nozzle smaller than or equal to about 700 μm was used, the sustained insulin release occurred in the artificial intestinal juice although the smaller capsules exhibited lower resistance to acidic conditions.

UR - http://www.scopus.com/inward/record.url?scp=83655164461&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=83655164461&partnerID=8YFLogxK

U2 - 10.1021/ie200915x

DO - 10.1021/ie200915x

M3 - Article

AN - SCOPUS:83655164461

VL - 50

SP - 13762

EP - 13770

JO - Industrial & Engineering Chemistry Product Research and Development

JF - Industrial & Engineering Chemistry Product Research and Development

SN - 0888-5885

IS - 24

ER -