Size-controlled synthesis of polymerized DNA nanoparticles for targeted anticancer drug delivery

Keonwook Nam; Taehyung Kim; Young Min Kim; Kyungjik Yang; Deokyoung Choe; Lawrence B. Mensah; Ki Young Choi; Young Hoon Roh

doi:10.1039/c9cc01442j

Size-controlled synthesis of polymerized DNA nanoparticles for targeted anticancer drug delivery

Keonwook Nam, Taehyung Kim, Young Min Kim, Kyungjik Yang, Deokyoung Choe, Lawrence B. Mensah, Ki Young Choi, Young Hoon Roh

Research output: Contribution to journal › Article › peer-review

20 Citations (Scopus)

Abstract

We synthesized size-tunable polymerized DNA nanoparticles (PDNs) for cancer-targeted drug delivery via sequential processes of rolling circle amplification, condensation, and layer-by-layer assembly. The PDNs selectively delivered anti-sense oligonucleotides to target cancer cells and exhibited size-dependent gene regulation efficacy.

Original language	English
Pages (from-to)	4905-4908
Number of pages	4
Journal	Chemical Communications
Volume	55
Issue number	34
DOIs	https://doi.org/10.1039/c9cc01442j
Publication status	Published - 2019

Bibliographical note

Funding Information:
This study was supported by the Young Researcher Program (No. 2015R1C1A1A02037770) and the Basic Science Research Program (No. 2018R1D1A1A02085552) through the National Research Foundation of Korea (NRF) funded by the Korean Government. This research was also supported by a grant (17162MFDS027) from the Ministry of Food and Drug Safety in 2019.

Publisher Copyright:
© The Royal Society of Chemistry 2019.

All Science Journal Classification (ASJC) codes

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
Chemistry(all)
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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10.1039/c9cc01442j

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title = "Size-controlled synthesis of polymerized DNA nanoparticles for targeted anticancer drug delivery",

abstract = "We synthesized size-tunable polymerized DNA nanoparticles (PDNs) for cancer-targeted drug delivery via sequential processes of rolling circle amplification, condensation, and layer-by-layer assembly. The PDNs selectively delivered anti-sense oligonucleotides to target cancer cells and exhibited size-dependent gene regulation efficacy.",

author = "Keonwook Nam and Taehyung Kim and Kim, {Young Min} and Kyungjik Yang and Deokyoung Choe and Mensah, {Lawrence B.} and Choi, {Ki Young} and Roh, {Young Hoon}",

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year = "2019",

doi = "10.1039/c9cc01442j",

language = "English",

volume = "55",

pages = "4905--4908",

journal = "Chemical Communications",

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T1 - Size-controlled synthesis of polymerized DNA nanoparticles for targeted anticancer drug delivery

AU - Nam, Keonwook

AU - Kim, Taehyung

AU - Kim, Young Min

AU - Yang, Kyungjik

AU - Choe, Deokyoung

AU - Mensah, Lawrence B.

AU - Choi, Ki Young

AU - Roh, Young Hoon

N1 - Funding Information: This study was supported by the Young Researcher Program (No. 2015R1C1A1A02037770) and the Basic Science Research Program (No. 2018R1D1A1A02085552) through the National Research Foundation of Korea (NRF) funded by the Korean Government. This research was also supported by a grant (17162MFDS027) from the Ministry of Food and Drug Safety in 2019. Publisher Copyright: © The Royal Society of Chemistry 2019.

PY - 2019

Y1 - 2019

N2 - We synthesized size-tunable polymerized DNA nanoparticles (PDNs) for cancer-targeted drug delivery via sequential processes of rolling circle amplification, condensation, and layer-by-layer assembly. The PDNs selectively delivered anti-sense oligonucleotides to target cancer cells and exhibited size-dependent gene regulation efficacy.

AB - We synthesized size-tunable polymerized DNA nanoparticles (PDNs) for cancer-targeted drug delivery via sequential processes of rolling circle amplification, condensation, and layer-by-layer assembly. The PDNs selectively delivered anti-sense oligonucleotides to target cancer cells and exhibited size-dependent gene regulation efficacy.

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DO - 10.1039/c9cc01442j

M3 - Article

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AN - SCOPUS:85065112772

SN - 1359-7345

VL - 55

SP - 4905

EP - 4908

JO - Chemical Communications

JF - Chemical Communications

IS - 34

ER -

Size-controlled synthesis of polymerized DNA nanoparticles for targeted anticancer drug delivery

Abstract

Bibliographical note

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