Size-controlled synthesis of polymerized DNA nanoparticles for targeted anticancer drug delivery

Keonwook Nam, Taehyung Kim, Young Min Kim, Kyungjik Yang, Deokyoung Choe, Lawrence B. Mensah, Ki Young Choi, Young Hoon Roh

Research output: Contribution to journalArticlepeer-review

20 Citations (Scopus)


We synthesized size-tunable polymerized DNA nanoparticles (PDNs) for cancer-targeted drug delivery via sequential processes of rolling circle amplification, condensation, and layer-by-layer assembly. The PDNs selectively delivered anti-sense oligonucleotides to target cancer cells and exhibited size-dependent gene regulation efficacy.

Original languageEnglish
Pages (from-to)4905-4908
Number of pages4
JournalChemical Communications
Issue number34
Publication statusPublished - 2019

Bibliographical note

Funding Information:
This study was supported by the Young Researcher Program (No. 2015R1C1A1A02037770) and the Basic Science Research Program (No. 2018R1D1A1A02085552) through the National Research Foundation of Korea (NRF) funded by the Korean Government. This research was also supported by a grant (17162MFDS027) from the Ministry of Food and Drug Safety in 2019.

Publisher Copyright:
© The Royal Society of Chemistry 2019.

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry


Dive into the research topics of 'Size-controlled synthesis of polymerized DNA nanoparticles for targeted anticancer drug delivery'. Together they form a unique fingerprint.

Cite this