We synthesized size-tunable polymerized DNA nanoparticles (PDNs) for cancer-targeted drug delivery via sequential processes of rolling circle amplification, condensation, and layer-by-layer assembly. The PDNs selectively delivered anti-sense oligonucleotides to target cancer cells and exhibited size-dependent gene regulation efficacy.
Bibliographical noteFunding Information:
This study was supported by the Young Researcher Program (No. 2015R1C1A1A02037770) and the Basic Science Research Program (No. 2018R1D1A1A02085552) through the National Research Foundation of Korea (NRF) funded by the Korean Government. This research was also supported by a grant (17162MFDS027) from the Ministry of Food and Drug Safety in 2019.
© The Royal Society of Chemistry 2019.
All Science Journal Classification (ASJC) codes
- Electronic, Optical and Magnetic Materials
- Ceramics and Composites
- Surfaces, Coatings and Films
- Metals and Alloys
- Materials Chemistry