Size-controlled synthesis of polymerized DNA nanoparticles for targeted anticancer drug delivery

Keonwook Nam, Taehyung Kim, Young Min Kim, Kyungjik Yang, Deokyoung Choe, Lawrence B. Mensah, Ki Young Choi, Young Hoon Roh

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

We synthesized size-tunable polymerized DNA nanoparticles (PDNs) for cancer-targeted drug delivery via sequential processes of rolling circle amplification, condensation, and layer-by-layer assembly. The PDNs selectively delivered anti-sense oligonucleotides to target cancer cells and exhibited size-dependent gene regulation efficacy.

Original languageEnglish
Pages (from-to)4905-4908
Number of pages4
JournalChemical Communications
Volume55
Issue number34
DOIs
Publication statusPublished - 2019 Jan 1

Fingerprint

DNA
Nanoparticles
Antisense Oligonucleotides
Oligonucleotides
Gene expression
Amplification
Condensation
Cells
Targeted drug delivery

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

Cite this

Nam, Keonwook ; Kim, Taehyung ; Kim, Young Min ; Yang, Kyungjik ; Choe, Deokyoung ; Mensah, Lawrence B. ; Choi, Ki Young ; Roh, Young Hoon. / Size-controlled synthesis of polymerized DNA nanoparticles for targeted anticancer drug delivery. In: Chemical Communications. 2019 ; Vol. 55, No. 34. pp. 4905-4908.
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Size-controlled synthesis of polymerized DNA nanoparticles for targeted anticancer drug delivery. / Nam, Keonwook; Kim, Taehyung; Kim, Young Min; Yang, Kyungjik; Choe, Deokyoung; Mensah, Lawrence B.; Choi, Ki Young; Roh, Young Hoon.

In: Chemical Communications, Vol. 55, No. 34, 01.01.2019, p. 4905-4908.

Research output: Contribution to journalArticle

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AU - Mensah, Lawrence B.

AU - Choi, Ki Young

AU - Roh, Young Hoon

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