Skin Barrier Restoration and Moisturization Using Horse Oil-Loaded Dissolving Microneedle Patches

Chisong Lee, Younghyon Andrew Eom, Huisuk Yang, Mingyu Jang, Sang Uk Jung, Ye Oak Park, Si Eun Lee, Hyungil Jung

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Background: Horse oil (HO) has skin barrier restoration and skin-moisturizing effects. Although cream formulations have been used widely and safely, their limited penetration through the stratum corneum is a major obstacle to maximizing the cosmetic efficacy of HO. Therefore, we aimed to encapsulate HO in a cosmetic dissolving microneedle (DMN) for efficient transdermal delivery. Methods: To overcome these limitations of skin permeation, HO-loaded DMN (HO-DMN) patches were developed and evaluated for their efficacy and safety using in vitro and clinical studies. Results: Despite the lipophilic nature of HO, the HO-DMN patches had a sharp shape and uniform array, with an average length and tip diameter of 388.36 ± 16.73 and 38.54 ± 5.29 μm, respectively. The mechanical strength of the HO-DMN patches was sufficient (fracture force of 0.29 ± 0.01 N), and they could successfully penetrate pig skin. During the 4-week clinical evaluation, HO-DMN patches caused significant improvements in skin and dermal density, skin elasticity, and moisturization. Additionally, a brief safety assessment showed that the HO-DMN patches induced negligible adverse events. Conclusion: The HO-DMNs are efficient, safe, and convenient for wide use in cosmetic applications for skin barrier restoration and moisturization.

Original languageEnglish
Pages (from-to)163-171
Number of pages9
JournalSkin Pharmacology and Physiology
Volume31
Issue number3
DOIs
Publication statusPublished - 2018 May 1

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Horses
Oils
Skin
Cosmetics
Safety
Elasticity
Cornea
Swine

All Science Journal Classification (ASJC) codes

  • Physiology
  • Pharmacology
  • Dermatology

Cite this

Lee, Chisong ; Eom, Younghyon Andrew ; Yang, Huisuk ; Jang, Mingyu ; Jung, Sang Uk ; Park, Ye Oak ; Lee, Si Eun ; Jung, Hyungil. / Skin Barrier Restoration and Moisturization Using Horse Oil-Loaded Dissolving Microneedle Patches. In: Skin Pharmacology and Physiology. 2018 ; Vol. 31, No. 3. pp. 163-171.
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title = "Skin Barrier Restoration and Moisturization Using Horse Oil-Loaded Dissolving Microneedle Patches",
abstract = "Background: Horse oil (HO) has skin barrier restoration and skin-moisturizing effects. Although cream formulations have been used widely and safely, their limited penetration through the stratum corneum is a major obstacle to maximizing the cosmetic efficacy of HO. Therefore, we aimed to encapsulate HO in a cosmetic dissolving microneedle (DMN) for efficient transdermal delivery. Methods: To overcome these limitations of skin permeation, HO-loaded DMN (HO-DMN) patches were developed and evaluated for their efficacy and safety using in vitro and clinical studies. Results: Despite the lipophilic nature of HO, the HO-DMN patches had a sharp shape and uniform array, with an average length and tip diameter of 388.36 ± 16.73 and 38.54 ± 5.29 μm, respectively. The mechanical strength of the HO-DMN patches was sufficient (fracture force of 0.29 ± 0.01 N), and they could successfully penetrate pig skin. During the 4-week clinical evaluation, HO-DMN patches caused significant improvements in skin and dermal density, skin elasticity, and moisturization. Additionally, a brief safety assessment showed that the HO-DMN patches induced negligible adverse events. Conclusion: The HO-DMNs are efficient, safe, and convenient for wide use in cosmetic applications for skin barrier restoration and moisturization.",
author = "Chisong Lee and Eom, {Younghyon Andrew} and Huisuk Yang and Mingyu Jang and Jung, {Sang Uk} and Park, {Ye Oak} and Lee, {Si Eun} and Hyungil Jung",
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Skin Barrier Restoration and Moisturization Using Horse Oil-Loaded Dissolving Microneedle Patches. / Lee, Chisong; Eom, Younghyon Andrew; Yang, Huisuk; Jang, Mingyu; Jung, Sang Uk; Park, Ye Oak; Lee, Si Eun; Jung, Hyungil.

In: Skin Pharmacology and Physiology, Vol. 31, No. 3, 01.05.2018, p. 163-171.

Research output: Contribution to journalArticle

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AU - Lee, Chisong

AU - Eom, Younghyon Andrew

AU - Yang, Huisuk

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AU - Jung, Sang Uk

AU - Park, Ye Oak

AU - Lee, Si Eun

AU - Jung, Hyungil

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N2 - Background: Horse oil (HO) has skin barrier restoration and skin-moisturizing effects. Although cream formulations have been used widely and safely, their limited penetration through the stratum corneum is a major obstacle to maximizing the cosmetic efficacy of HO. Therefore, we aimed to encapsulate HO in a cosmetic dissolving microneedle (DMN) for efficient transdermal delivery. Methods: To overcome these limitations of skin permeation, HO-loaded DMN (HO-DMN) patches were developed and evaluated for their efficacy and safety using in vitro and clinical studies. Results: Despite the lipophilic nature of HO, the HO-DMN patches had a sharp shape and uniform array, with an average length and tip diameter of 388.36 ± 16.73 and 38.54 ± 5.29 μm, respectively. The mechanical strength of the HO-DMN patches was sufficient (fracture force of 0.29 ± 0.01 N), and they could successfully penetrate pig skin. During the 4-week clinical evaluation, HO-DMN patches caused significant improvements in skin and dermal density, skin elasticity, and moisturization. Additionally, a brief safety assessment showed that the HO-DMN patches induced negligible adverse events. Conclusion: The HO-DMNs are efficient, safe, and convenient for wide use in cosmetic applications for skin barrier restoration and moisturization.

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