Skin disorders in Korean patients infected with human immunodeficiency virus and their association with a CD4 lymphocyte count

A preliminary study

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Abstract

Background: Dermatological disorders are quite common in human immunodeficiency virus (HIV)-infected patients. However, cutaneous findings in Korean HIV-infected patients have not been properly investigated. Objective: To investigate the spectrum of dermatological disorders in Korean HIV-infected individuals according to a CD4 lymphocyte count. Methods: A retrospective clinical study was carried out from June 2002 to January 2008. We comprehensively collected information regarding HIV-associated skin problems, laboratory data and the history of highly active antiretroviral therapy (HAART). Results: Ninety-nine HIV-seropositive patients (mean age: 39.6 ± 11.3 years, males: 94.9%) were included in this study. Of them, 55 patients (55.6%) presented with at least one skin problem. The four most common dermatological disorders were eosinophilic pustular folliculitis (18.6%), symptomatic syphilis (comprising of primary and secondary syphilis) (17.1%), seborrhoeic dermatitis (17.1%) and condyloma acuminatum (12.8%). The group with a CD4 lymphocyte count < 200 × 106 cells/L showed a significantly higher prevalence of Kaposi sarcoma compared with the group with a CD4 lymphocyte count > 200 × 106 cells/L (P = 0.014). Condyloma was more prevalent in the group with a CD4 count > 200 × 106 cells/L (P = 0.022). The patients treated with HAART had a lower prevalence of neurosyphilis compared with the non-treated group (P = 0.018). Conclusions: Diverse dermatological conditions were demonstrated in Korean HIV-infected patients. Kaposi sarcoma was associated with a low CD4 lymphocyte count, but condyloma was associated with a high CD4 lymphocyte count. The prevalence of syphilis in our study was higher than that of Western countries. HAART seemed to be associated with the low prevalence of neurosyphilis.

Original languageEnglish
Pages (from-to)1476-1480
Number of pages5
JournalJournal of the European Academy of Dermatology and Venereology
Volume24
Issue number12
DOIs
Publication statusPublished - 2010 Dec 1

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CD4 Lymphocyte Count
HIV
Skin
Highly Active Antiretroviral Therapy
Neurosyphilis
Syphilis
Condylomata Acuminata
Kaposi's Sarcoma
Dermatitis
Retrospective Studies
History

All Science Journal Classification (ASJC) codes

  • Dermatology
  • Infectious Diseases

Cite this

@article{543b2736094b4b20895aec1fc82a61c5,
title = "Skin disorders in Korean patients infected with human immunodeficiency virus and their association with a CD4 lymphocyte count: A preliminary study",
abstract = "Background: Dermatological disorders are quite common in human immunodeficiency virus (HIV)-infected patients. However, cutaneous findings in Korean HIV-infected patients have not been properly investigated. Objective: To investigate the spectrum of dermatological disorders in Korean HIV-infected individuals according to a CD4 lymphocyte count. Methods: A retrospective clinical study was carried out from June 2002 to January 2008. We comprehensively collected information regarding HIV-associated skin problems, laboratory data and the history of highly active antiretroviral therapy (HAART). Results: Ninety-nine HIV-seropositive patients (mean age: 39.6 ± 11.3 years, males: 94.9{\%}) were included in this study. Of them, 55 patients (55.6{\%}) presented with at least one skin problem. The four most common dermatological disorders were eosinophilic pustular folliculitis (18.6{\%}), symptomatic syphilis (comprising of primary and secondary syphilis) (17.1{\%}), seborrhoeic dermatitis (17.1{\%}) and condyloma acuminatum (12.8{\%}). The group with a CD4 lymphocyte count < 200 × 106 cells/L showed a significantly higher prevalence of Kaposi sarcoma compared with the group with a CD4 lymphocyte count > 200 × 106 cells/L (P = 0.014). Condyloma was more prevalent in the group with a CD4 count > 200 × 106 cells/L (P = 0.022). The patients treated with HAART had a lower prevalence of neurosyphilis compared with the non-treated group (P = 0.018). Conclusions: Diverse dermatological conditions were demonstrated in Korean HIV-infected patients. Kaposi sarcoma was associated with a low CD4 lymphocyte count, but condyloma was associated with a high CD4 lymphocyte count. The prevalence of syphilis in our study was higher than that of Western countries. HAART seemed to be associated with the low prevalence of neurosyphilis.",
author = "Kim, {T. G.} and Kwanghoon Lee and SangHo Oh",
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T1 - Skin disorders in Korean patients infected with human immunodeficiency virus and their association with a CD4 lymphocyte count

T2 - A preliminary study

AU - Kim, T. G.

AU - Lee, Kwanghoon

AU - Oh, SangHo

PY - 2010/12/1

Y1 - 2010/12/1

N2 - Background: Dermatological disorders are quite common in human immunodeficiency virus (HIV)-infected patients. However, cutaneous findings in Korean HIV-infected patients have not been properly investigated. Objective: To investigate the spectrum of dermatological disorders in Korean HIV-infected individuals according to a CD4 lymphocyte count. Methods: A retrospective clinical study was carried out from June 2002 to January 2008. We comprehensively collected information regarding HIV-associated skin problems, laboratory data and the history of highly active antiretroviral therapy (HAART). Results: Ninety-nine HIV-seropositive patients (mean age: 39.6 ± 11.3 years, males: 94.9%) were included in this study. Of them, 55 patients (55.6%) presented with at least one skin problem. The four most common dermatological disorders were eosinophilic pustular folliculitis (18.6%), symptomatic syphilis (comprising of primary and secondary syphilis) (17.1%), seborrhoeic dermatitis (17.1%) and condyloma acuminatum (12.8%). The group with a CD4 lymphocyte count < 200 × 106 cells/L showed a significantly higher prevalence of Kaposi sarcoma compared with the group with a CD4 lymphocyte count > 200 × 106 cells/L (P = 0.014). Condyloma was more prevalent in the group with a CD4 count > 200 × 106 cells/L (P = 0.022). The patients treated with HAART had a lower prevalence of neurosyphilis compared with the non-treated group (P = 0.018). Conclusions: Diverse dermatological conditions were demonstrated in Korean HIV-infected patients. Kaposi sarcoma was associated with a low CD4 lymphocyte count, but condyloma was associated with a high CD4 lymphocyte count. The prevalence of syphilis in our study was higher than that of Western countries. HAART seemed to be associated with the low prevalence of neurosyphilis.

AB - Background: Dermatological disorders are quite common in human immunodeficiency virus (HIV)-infected patients. However, cutaneous findings in Korean HIV-infected patients have not been properly investigated. Objective: To investigate the spectrum of dermatological disorders in Korean HIV-infected individuals according to a CD4 lymphocyte count. Methods: A retrospective clinical study was carried out from June 2002 to January 2008. We comprehensively collected information regarding HIV-associated skin problems, laboratory data and the history of highly active antiretroviral therapy (HAART). Results: Ninety-nine HIV-seropositive patients (mean age: 39.6 ± 11.3 years, males: 94.9%) were included in this study. Of them, 55 patients (55.6%) presented with at least one skin problem. The four most common dermatological disorders were eosinophilic pustular folliculitis (18.6%), symptomatic syphilis (comprising of primary and secondary syphilis) (17.1%), seborrhoeic dermatitis (17.1%) and condyloma acuminatum (12.8%). The group with a CD4 lymphocyte count < 200 × 106 cells/L showed a significantly higher prevalence of Kaposi sarcoma compared with the group with a CD4 lymphocyte count > 200 × 106 cells/L (P = 0.014). Condyloma was more prevalent in the group with a CD4 count > 200 × 106 cells/L (P = 0.022). The patients treated with HAART had a lower prevalence of neurosyphilis compared with the non-treated group (P = 0.018). Conclusions: Diverse dermatological conditions were demonstrated in Korean HIV-infected patients. Kaposi sarcoma was associated with a low CD4 lymphocyte count, but condyloma was associated with a high CD4 lymphocyte count. The prevalence of syphilis in our study was higher than that of Western countries. HAART seemed to be associated with the low prevalence of neurosyphilis.

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DO - 10.1111/j.1468-3083.2010.03675.x

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JO - Journal of the European Academy of Dermatology and Venereology

JF - Journal of the European Academy of Dermatology and Venereology

SN - 0926-9959

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