Sleep disturbance may alter white matter and resting state functional connectivities in Parkinson's disease

Seok Jong Chung, Yong Ho Choi, Hunki Kwon, Yeong Hun Park, Hyuk Jin Yun, Han Soo Yoo, Seock Hyeon Moon, Byoung Seok Ye, Young H. Sohn, Jong Min Lee, Phil Hyu Lee

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Study Objectives: To clarify whether sleep disturbance would alter the patterns of structural and functional networks underlying cognitive dysfunction in patients with Parkinson's disease (PD). Methods: Among the 180 patients with nondemented PD in our cohort, 45 patients were classified as the group with sleep disturbance according to the 5-item scales for outcomes in Parkinson's disease nighttime scale. Based on propensity scores, another 45 PD patients without sleep disturbance were matched to this group. We performed a comparative analysis of cortical thickness, diffusion tensor imaging-based white matter integrity, resting-state functional connectivity, and cognitive performance between PD patients with and without sleep disturbance. Results: PD patients with sleep disturbance showed poorer performance in attention and working memory and a tendency toward a lower score in frontal executive function relative to those without sleep disturbance. The PD with sleep disturbance group exhibited widespread white matter disintegration compared to the PD without sleep disturbance group, although there were no significant differences in cortical thickness between the PD subgroups. On functional network analysis, PD patients with sleep disturbance exhibited less severely decreased cortical functional connectivity within the default mode network, central executive network, and dorsal attention network when compared to those without sleep disturbance. Conclusions: The present study suggests that sleep disturbance in PD patients could be associated with white matter and functional network alterations in conjunction with cognitive impairment.

Original languageEnglish
Article numberzsx009
JournalSleep
Volume40
Issue number3
DOIs
Publication statusPublished - 2017 Mar 1

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Parkinson Disease
Sleep
White Matter
Propensity Score
Diffusion Tensor Imaging
Executive Function
Short-Term Memory
Research Design

All Science Journal Classification (ASJC) codes

  • Clinical Neurology
  • Physiology (medical)

Cite this

Chung, Seok Jong ; Choi, Yong Ho ; Kwon, Hunki ; Park, Yeong Hun ; Yun, Hyuk Jin ; Yoo, Han Soo ; Moon, Seock Hyeon ; Ye, Byoung Seok ; Sohn, Young H. ; Lee, Jong Min ; Lee, Phil Hyu. / Sleep disturbance may alter white matter and resting state functional connectivities in Parkinson's disease. In: Sleep. 2017 ; Vol. 40, No. 3.
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abstract = "Study Objectives: To clarify whether sleep disturbance would alter the patterns of structural and functional networks underlying cognitive dysfunction in patients with Parkinson's disease (PD). Methods: Among the 180 patients with nondemented PD in our cohort, 45 patients were classified as the group with sleep disturbance according to the 5-item scales for outcomes in Parkinson's disease nighttime scale. Based on propensity scores, another 45 PD patients without sleep disturbance were matched to this group. We performed a comparative analysis of cortical thickness, diffusion tensor imaging-based white matter integrity, resting-state functional connectivity, and cognitive performance between PD patients with and without sleep disturbance. Results: PD patients with sleep disturbance showed poorer performance in attention and working memory and a tendency toward a lower score in frontal executive function relative to those without sleep disturbance. The PD with sleep disturbance group exhibited widespread white matter disintegration compared to the PD without sleep disturbance group, although there were no significant differences in cortical thickness between the PD subgroups. On functional network analysis, PD patients with sleep disturbance exhibited less severely decreased cortical functional connectivity within the default mode network, central executive network, and dorsal attention network when compared to those without sleep disturbance. Conclusions: The present study suggests that sleep disturbance in PD patients could be associated with white matter and functional network alterations in conjunction with cognitive impairment.",
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Chung, SJ, Choi, YH, Kwon, H, Park, YH, Yun, HJ, Yoo, HS, Moon, SH, Ye, BS, Sohn, YH, Lee, JM & Lee, PH 2017, 'Sleep disturbance may alter white matter and resting state functional connectivities in Parkinson's disease', Sleep, vol. 40, no. 3, zsx009. https://doi.org/10.1093/sleep/zsx009

Sleep disturbance may alter white matter and resting state functional connectivities in Parkinson's disease. / Chung, Seok Jong; Choi, Yong Ho; Kwon, Hunki; Park, Yeong Hun; Yun, Hyuk Jin; Yoo, Han Soo; Moon, Seock Hyeon; Ye, Byoung Seok; Sohn, Young H.; Lee, Jong Min; Lee, Phil Hyu.

In: Sleep, Vol. 40, No. 3, zsx009, 01.03.2017.

Research output: Contribution to journalArticle

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AU - Choi, Yong Ho

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AU - Park, Yeong Hun

AU - Yun, Hyuk Jin

AU - Yoo, Han Soo

AU - Moon, Seock Hyeon

AU - Ye, Byoung Seok

AU - Sohn, Young H.

AU - Lee, Jong Min

AU - Lee, Phil Hyu

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N2 - Study Objectives: To clarify whether sleep disturbance would alter the patterns of structural and functional networks underlying cognitive dysfunction in patients with Parkinson's disease (PD). Methods: Among the 180 patients with nondemented PD in our cohort, 45 patients were classified as the group with sleep disturbance according to the 5-item scales for outcomes in Parkinson's disease nighttime scale. Based on propensity scores, another 45 PD patients without sleep disturbance were matched to this group. We performed a comparative analysis of cortical thickness, diffusion tensor imaging-based white matter integrity, resting-state functional connectivity, and cognitive performance between PD patients with and without sleep disturbance. Results: PD patients with sleep disturbance showed poorer performance in attention and working memory and a tendency toward a lower score in frontal executive function relative to those without sleep disturbance. The PD with sleep disturbance group exhibited widespread white matter disintegration compared to the PD without sleep disturbance group, although there were no significant differences in cortical thickness between the PD subgroups. On functional network analysis, PD patients with sleep disturbance exhibited less severely decreased cortical functional connectivity within the default mode network, central executive network, and dorsal attention network when compared to those without sleep disturbance. Conclusions: The present study suggests that sleep disturbance in PD patients could be associated with white matter and functional network alterations in conjunction with cognitive impairment.

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