Wearable electronic devices that can monitor physiological signals of the human body to provide biomedical information have been drawing extensive interests for sustainable personal health management. Here, we report a human pilot trial of a soft, smart contact lens and a skin-attachable therapeutic device for wireless monitoring and therapy of chronic ocular surface inflammation (OSI). As a diagnostic device, this smart contact lens enables real-time measurement of the concentration of matrix metalloproteinase-9, a biomarker for OSI, in tears using a graphene field-effect transistor. As a therapeutic device, we also fabricated a stretchable and transparent heat patch attachable on the human eyelid conformably. Both diagnostic and therapeutic devices can be incorporated using a smartphone for their wireless communications, thereby achieving instantaneous diagnosis of OSI and automated hyperthermia treatments. Furthermore, in vivo tests using live animals and human subjects confirm their good biocompatibility and reliability as a noninvasive, mobile health care solution.
|Publication status||Published - 2021 Mar|
Bibliographical noteFunding Information:
This work was supported by the Ministry of Science and ICT (MSIT) and the Ministry of Trade, Industry and Energy (MOTIE) of Korea through the National Research Foundation (2019R1A2B5B03069358 and 2016R1A5A1009926), the Korea Initiative for fostering University of Research and Innovation (KIURI) Program (2020M3H1A1077207), the Bio and Medical Technology Development Program (2018M3A9F1021649), the Nano Material Technology Development Program (2016M3A7B4910635), and the Technology Innovation Program (20010366 and 20013621, Center for Super Critical Material Industrial Technology). We also gratefully acknowledge the financial support by the Research Program (2019-22-0228) funded by Yonsei University
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