Smart contact lens and transparent heat patch for remote monitoring and therapy of chronic ocular surface inflammation using mobiles

Jiuk Jang; Joohee Kim; Haein Shin; Young Geun Park; Byung Jun Joo; Hunkyu Seo; Jong Eun Won; Dai Woo Kim; Chang Young Lee; Hong Kyun Kim; Jang Ung Park

doi:10.1126/sciadv.abf7194

Smart contact lens and transparent heat patch for remote monitoring and therapy of chronic ocular surface inflammation using mobiles

Jiuk Jang, Joohee Kim, Haein Shin, Young Geun Park, Byung Jun Joo, Hunkyu Seo, Jong Eun Won, Dai Woo Kim, Chang Young Lee, Hong Kyun Kim, Jang Ung Park

Department of Materials Science and Engineering

Research output: Contribution to journal › Article › peer-review

20 Citations (Scopus)

Abstract

Wearable electronic devices that can monitor physiological signals of the human body to provide biomedical information have been drawing extensive interests for sustainable personal health management. Here, we report a human pilot trial of a soft, smart contact lens and a skin-attachable therapeutic device for wireless monitoring and therapy of chronic ocular surface inflammation (OSI). As a diagnostic device, this smart contact lens enables real-time measurement of the concentration of matrix metalloproteinase-9, a biomarker for OSI, in tears using a graphene field-effect transistor. As a therapeutic device, we also fabricated a stretchable and transparent heat patch attachable on the human eyelid conformably. Both diagnostic and therapeutic devices can be incorporated using a smartphone for their wireless communications, thereby achieving instantaneous diagnosis of OSI and automated hyperthermia treatments. Furthermore, in vivo tests using live animals and human subjects confirm their good biocompatibility and reliability as a noninvasive, mobile health care solution.

Original language	English
Article number	eabf7194
Journal	Science Advances
Volume	7
Issue number	14
DOIs	https://doi.org/10.1126/sciadv.abf7194
Publication status	Published - 2021 Mar

Bibliographical note

Funding Information:
This work was supported by the Ministry of Science and ICT (MSIT) and the Ministry of Trade, Industry and Energy (MOTIE) of Korea through the National Research Foundation (2019R1A2B5B03069358 and 2016R1A5A1009926), the Korea Initiative for fostering University of Research and Innovation (KIURI) Program (2020M3H1A1077207), the Bio and Medical Technology Development Program (2018M3A9F1021649), the Nano Material Technology Development Program (2016M3A7B4910635), and the Technology Innovation Program (20010366 and 20013621, Center for Super Critical Material Industrial Technology). We also gratefully acknowledge the financial support by the Research Program (2019-22-0228) funded by Yonsei University

Publisher Copyright:
Copyright © 2021 The Authors, some rights reserved.

All Science Journal Classification (ASJC) codes

General

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Cite this

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title = "Smart contact lens and transparent heat patch for remote monitoring and therapy of chronic ocular surface inflammation using mobiles",

abstract = "Wearable electronic devices that can monitor physiological signals of the human body to provide biomedical information have been drawing extensive interests for sustainable personal health management. Here, we report a human pilot trial of a soft, smart contact lens and a skin-attachable therapeutic device for wireless monitoring and therapy of chronic ocular surface inflammation (OSI). As a diagnostic device, this smart contact lens enables real-time measurement of the concentration of matrix metalloproteinase-9, a biomarker for OSI, in tears using a graphene field-effect transistor. As a therapeutic device, we also fabricated a stretchable and transparent heat patch attachable on the human eyelid conformably. Both diagnostic and therapeutic devices can be incorporated using a smartphone for their wireless communications, thereby achieving instantaneous diagnosis of OSI and automated hyperthermia treatments. Furthermore, in vivo tests using live animals and human subjects confirm their good biocompatibility and reliability as a noninvasive, mobile health care solution.",

author = "Jiuk Jang and Joohee Kim and Haein Shin and Park, {Young Geun} and Joo, {Byung Jun} and Hunkyu Seo and Won, {Jong Eun} and Kim, {Dai Woo} and Lee, {Chang Young} and Kim, {Hong Kyun} and Park, {Jang Ung}",

note = "Funding Information: This work was supported by the Ministry of Science and ICT (MSIT) and the Ministry of Trade, Industry and Energy (MOTIE) of Korea through the National Research Foundation (2019R1A2B5B03069358 and 2016R1A5A1009926), the Korea Initiative for fostering University of Research and Innovation (KIURI) Program (2020M3H1A1077207), the Bio and Medical Technology Development Program (2018M3A9F1021649), the Nano Material Technology Development Program (2016M3A7B4910635), and the Technology Innovation Program (20010366 and 20013621, Center for Super Critical Material Industrial Technology). We also gratefully acknowledge the financial support by the Research Program (2019-22-0228) funded by Yonsei University Publisher Copyright: Copyright {\textcopyright} 2021 The Authors, some rights reserved.",

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doi = "10.1126/sciadv.abf7194",

language = "English",

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AU - Kim, Joohee

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AU - Joo, Byung Jun

AU - Seo, Hunkyu

AU - Won, Jong Eun

AU - Kim, Dai Woo

AU - Lee, Chang Young

AU - Kim, Hong Kyun

AU - Park, Jang Ung

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PY - 2021/3

Y1 - 2021/3

N2 - Wearable electronic devices that can monitor physiological signals of the human body to provide biomedical information have been drawing extensive interests for sustainable personal health management. Here, we report a human pilot trial of a soft, smart contact lens and a skin-attachable therapeutic device for wireless monitoring and therapy of chronic ocular surface inflammation (OSI). As a diagnostic device, this smart contact lens enables real-time measurement of the concentration of matrix metalloproteinase-9, a biomarker for OSI, in tears using a graphene field-effect transistor. As a therapeutic device, we also fabricated a stretchable and transparent heat patch attachable on the human eyelid conformably. Both diagnostic and therapeutic devices can be incorporated using a smartphone for their wireless communications, thereby achieving instantaneous diagnosis of OSI and automated hyperthermia treatments. Furthermore, in vivo tests using live animals and human subjects confirm their good biocompatibility and reliability as a noninvasive, mobile health care solution.

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Smart contact lens and transparent heat patch for remote monitoring and therapy of chronic ocular surface inflammation using mobiles

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

UN SDGs

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