Smart nanoprobes for ultrasensitive detection of breast cancer via magnetic resonance imaging

Jaemin Lee, Jaemoon Yang, Sung Baek Seo, Hyun Ju Ko, Jin Suck Suh, Yong Min Huh, Seungjoo Haam

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Antibody-conjugated hydrophilic magnetic nanocrystals for use as smart nanoprobes were developed for ultrasensitive detection of breast cancer via magnetic resonance (MR) imaging. MnFe2O4 nanocrystals (MNCs) for use as MR imaging contrast agents were synthesized by thermal decomposition to take advantage of their MR signal enhancement effect. The MNC surfaces were then modified with amphiphilic tri-block copolymers (dicarboxy poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol)), not only allowing the MNCs to transfer from the organic to the aqueous phase, but also increasing the colloidal stability of the MNCs by masking poly(ethylene glycol). The physicochemical properties of the synthesized hydrophilic magnetic nanocrystals (HMNCs) were fully investigated. Trastuzumab (TZ), a monoclonal antibody against human epidermal growth factor receptor (HER2/neu), was further conjugated on the surface of HMNCs to specifically target HER2/neu over-expressed breast cancer cells. MR imaging analysis of target cells treated with TZ-conjugated HMNCs (TZ-HMNCs) clearly demonstrated their potential as high-performance nanoprobes for selective imaging.

Original languageEnglish
Article number485101
JournalNanotechnology
Volume19
Issue number48
DOIs
Publication statusPublished - 2008 Dec 3

Fingerprint

Nanoprobes
Magnetic resonance
Nanocrystals
Imaging techniques
Polyethylene glycols
Propylene Glycol
Monoclonal antibodies
Glycols
Epidermal Growth Factor Receptor
Antibodies
Contrast Media
Block copolymers
Polypropylenes
Pyrolysis
Monoclonal Antibodies
Cells
manganese ferrite

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Chemistry(all)
  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering
  • Electrical and Electronic Engineering

Cite this

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Smart nanoprobes for ultrasensitive detection of breast cancer via magnetic resonance imaging. / Lee, Jaemin; Yang, Jaemoon; Seo, Sung Baek; Ko, Hyun Ju; Suh, Jin Suck; Huh, Yong Min; Haam, Seungjoo.

In: Nanotechnology, Vol. 19, No. 48, 485101, 03.12.2008.

Research output: Contribution to journalArticle

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