Smoking, alcohol and gastric cancer risk in Korean men: The National Health Insurance Corporation Study

N. Y. Sung, K. S. Choi, E. C. Park, K. Park, S. Y. Lee, A. K. Lee, I. J. Choi, K. W. Jung, Y. J. Won, H. R. Shin

Research output: Contribution to journalArticlepeer-review

75 Citations (Scopus)

Abstract

We investigated the risk of gastric cancer by subsite in relation to cigarette smoking and alcohol in a large population-based cohort of 669 570 Korean men in an insurance plan followed for an average 6.5 years, yielding 3452 new cases of gastric cancer, of which 127 were cardia and upper-third gastric cancer, 2409 were distal gastric cancer and 1007 were unclassified. A moderate association was found between smoking, cardia and upper-third (adjusted relative risk (aRR) 2.2; 95% confidence interval (CI) 1.4-3.5) and distal cancers (aRR=1.4; 95% CI=1.3-1.6). We also found a positive association between alcohol consumption and distal (aRR=1.3; 95% CI=1.2-1.5) and total (aRR=1.2; 95% CI=1.1-1.4) gastric cancer. Combined exposure to high levels of tobacco and alcohol increased the risk estimates further; cardia and upper-third gastric cancers were more strongly related to smoking status than distal gastric cancer.

Original languageEnglish
Pages (from-to)700-704
Number of pages5
JournalBritish journal of cancer
Volume97
Issue number5
DOIs
Publication statusPublished - 2007 Aug 28

Bibliographical note

Funding Information:
We thank the Korean Central Cancer Registry (KCCR) and the National Health Insurance Corporation for providing help. This work was supported by National Cancer Center grant 0710131-1.

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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