Smoking and projected cardiovascular risk in an HIV-positive Asian regional cohort

T. C. Do, D. Boettiger, M. Law, S. Pujari, F. Zhang, R. Chaiwarith, S. Kiertiburanakul, M. P. Lee, R. Ditangco, W. W. Wong, K. V. Nguyen, T. P. Merati, T. T. Pham, A. Kamarulzaman, S. Oka, E. Yunihastuti, N. Kumarasamy, P. Kantipong, JunYong Choi, O. T. Ng & 2 others N. Durier, K. Ruxrungtham

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Objectives: The aim of the study was to assess the prevalence and characteristics associated with current smoking in an Asian HIV-positive cohort, to calculate the predictive risks of cardiovascular disease (CVD), coronary heart disease (CHD) and myocardial infarction (MI), and to identify the impact that simulated interventions may have. Methods: Logistic regression analysis was used to distinguish associated current smoking characteristics. Five-year predictive risks of CVD, CHD and MI and the impact of simulated interventions were calculated utilizing the Data Collection on Adverse Effects of Anti-HIV Drugs Study (D:A:D) algorithm. Results: Smoking status data were collected from 4274 participants and 1496 of these had sufficient data for simulated intervention calculations. Current smoking prevalence in these two groups was similar (23.2% vs. 19.9%, respectively). Characteristics associated with current smoking included age > 50 years compared with 30–39 years [odds ratio (OR) 0.65; 95% confidence interval (CI) 0.51–0.83], HIV exposure through injecting drug use compared with heterosexual exposure (OR 3.03; 95% CI 2.25–4.07), and receiving antiretroviral therapy (ART) at study sites in Singapore, South Korea, Malaysia, Japan and Vietnam in comparison to Thailand (all OR > 2). Women were less likely to smoke than men (OR 0.11; 95% CI 0.08–0.14). In simulated interventions, smoking cessation demonstrated the greatest impact in reducing CVD and CHD risk and closely approximated the impact of switching from abacavir to an alternate antiretroviral in the reduction of 5-year MI risk. Conclusions: Multiple interventions could reduce CVD, CHD and MI risk in Asian HIV-positive patients, with smoking cessation potentially being the most influential.

Original languageEnglish
Pages (from-to)542-549
Number of pages8
JournalHIV Medicine
Volume17
Issue number7
DOIs
Publication statusPublished - 2016 Aug 1

Fingerprint

Smoking
HIV
Coronary Disease
Cardiovascular Diseases
Odds Ratio
Myocardial Infarction
Smoking Cessation
Confidence Intervals
Anti-HIV Agents
Republic of Korea
Vietnam
Malaysia
Singapore
Heterosexuality
Thailand
Smoke
Japan
Logistic Models
Regression Analysis
Pharmaceutical Preparations

All Science Journal Classification (ASJC) codes

  • Health Policy
  • Infectious Diseases
  • Pharmacology (medical)

Cite this

Do, T. C., Boettiger, D., Law, M., Pujari, S., Zhang, F., Chaiwarith, R., ... Ruxrungtham, K. (2016). Smoking and projected cardiovascular risk in an HIV-positive Asian regional cohort. HIV Medicine, 17(7), 542-549. https://doi.org/10.1111/hiv.12358
Do, T. C. ; Boettiger, D. ; Law, M. ; Pujari, S. ; Zhang, F. ; Chaiwarith, R. ; Kiertiburanakul, S. ; Lee, M. P. ; Ditangco, R. ; Wong, W. W. ; Nguyen, K. V. ; Merati, T. P. ; Pham, T. T. ; Kamarulzaman, A. ; Oka, S. ; Yunihastuti, E. ; Kumarasamy, N. ; Kantipong, P. ; Choi, JunYong ; Ng, O. T. ; Durier, N. ; Ruxrungtham, K. / Smoking and projected cardiovascular risk in an HIV-positive Asian regional cohort. In: HIV Medicine. 2016 ; Vol. 17, No. 7. pp. 542-549.
@article{f2e5b1945c1742a7b2e5adc22f9701bb,
title = "Smoking and projected cardiovascular risk in an HIV-positive Asian regional cohort",
abstract = "Objectives: The aim of the study was to assess the prevalence and characteristics associated with current smoking in an Asian HIV-positive cohort, to calculate the predictive risks of cardiovascular disease (CVD), coronary heart disease (CHD) and myocardial infarction (MI), and to identify the impact that simulated interventions may have. Methods: Logistic regression analysis was used to distinguish associated current smoking characteristics. Five-year predictive risks of CVD, CHD and MI and the impact of simulated interventions were calculated utilizing the Data Collection on Adverse Effects of Anti-HIV Drugs Study (D:A:D) algorithm. Results: Smoking status data were collected from 4274 participants and 1496 of these had sufficient data for simulated intervention calculations. Current smoking prevalence in these two groups was similar (23.2{\%} vs. 19.9{\%}, respectively). Characteristics associated with current smoking included age > 50 years compared with 30–39 years [odds ratio (OR) 0.65; 95{\%} confidence interval (CI) 0.51–0.83], HIV exposure through injecting drug use compared with heterosexual exposure (OR 3.03; 95{\%} CI 2.25–4.07), and receiving antiretroviral therapy (ART) at study sites in Singapore, South Korea, Malaysia, Japan and Vietnam in comparison to Thailand (all OR > 2). Women were less likely to smoke than men (OR 0.11; 95{\%} CI 0.08–0.14). In simulated interventions, smoking cessation demonstrated the greatest impact in reducing CVD and CHD risk and closely approximated the impact of switching from abacavir to an alternate antiretroviral in the reduction of 5-year MI risk. Conclusions: Multiple interventions could reduce CVD, CHD and MI risk in Asian HIV-positive patients, with smoking cessation potentially being the most influential.",
author = "Do, {T. C.} and D. Boettiger and M. Law and S. Pujari and F. Zhang and R. Chaiwarith and S. Kiertiburanakul and Lee, {M. P.} and R. Ditangco and Wong, {W. W.} and Nguyen, {K. V.} and Merati, {T. P.} and Pham, {T. T.} and A. Kamarulzaman and S. Oka and E. Yunihastuti and N. Kumarasamy and P. Kantipong and JunYong Choi and Ng, {O. T.} and N. Durier and K. Ruxrungtham",
year = "2016",
month = "8",
day = "1",
doi = "10.1111/hiv.12358",
language = "English",
volume = "17",
pages = "542--549",
journal = "HIV Medicine",
issn = "1464-2662",
publisher = "Wiley-Blackwell",
number = "7",

}

Do, TC, Boettiger, D, Law, M, Pujari, S, Zhang, F, Chaiwarith, R, Kiertiburanakul, S, Lee, MP, Ditangco, R, Wong, WW, Nguyen, KV, Merati, TP, Pham, TT, Kamarulzaman, A, Oka, S, Yunihastuti, E, Kumarasamy, N, Kantipong, P, Choi, J, Ng, OT, Durier, N & Ruxrungtham, K 2016, 'Smoking and projected cardiovascular risk in an HIV-positive Asian regional cohort', HIV Medicine, vol. 17, no. 7, pp. 542-549. https://doi.org/10.1111/hiv.12358

Smoking and projected cardiovascular risk in an HIV-positive Asian regional cohort. / Do, T. C.; Boettiger, D.; Law, M.; Pujari, S.; Zhang, F.; Chaiwarith, R.; Kiertiburanakul, S.; Lee, M. P.; Ditangco, R.; Wong, W. W.; Nguyen, K. V.; Merati, T. P.; Pham, T. T.; Kamarulzaman, A.; Oka, S.; Yunihastuti, E.; Kumarasamy, N.; Kantipong, P.; Choi, JunYong; Ng, O. T.; Durier, N.; Ruxrungtham, K.

In: HIV Medicine, Vol. 17, No. 7, 01.08.2016, p. 542-549.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Smoking and projected cardiovascular risk in an HIV-positive Asian regional cohort

AU - Do, T. C.

AU - Boettiger, D.

AU - Law, M.

AU - Pujari, S.

AU - Zhang, F.

AU - Chaiwarith, R.

AU - Kiertiburanakul, S.

AU - Lee, M. P.

AU - Ditangco, R.

AU - Wong, W. W.

AU - Nguyen, K. V.

AU - Merati, T. P.

AU - Pham, T. T.

AU - Kamarulzaman, A.

AU - Oka, S.

AU - Yunihastuti, E.

AU - Kumarasamy, N.

AU - Kantipong, P.

AU - Choi, JunYong

AU - Ng, O. T.

AU - Durier, N.

AU - Ruxrungtham, K.

PY - 2016/8/1

Y1 - 2016/8/1

N2 - Objectives: The aim of the study was to assess the prevalence and characteristics associated with current smoking in an Asian HIV-positive cohort, to calculate the predictive risks of cardiovascular disease (CVD), coronary heart disease (CHD) and myocardial infarction (MI), and to identify the impact that simulated interventions may have. Methods: Logistic regression analysis was used to distinguish associated current smoking characteristics. Five-year predictive risks of CVD, CHD and MI and the impact of simulated interventions were calculated utilizing the Data Collection on Adverse Effects of Anti-HIV Drugs Study (D:A:D) algorithm. Results: Smoking status data were collected from 4274 participants and 1496 of these had sufficient data for simulated intervention calculations. Current smoking prevalence in these two groups was similar (23.2% vs. 19.9%, respectively). Characteristics associated with current smoking included age > 50 years compared with 30–39 years [odds ratio (OR) 0.65; 95% confidence interval (CI) 0.51–0.83], HIV exposure through injecting drug use compared with heterosexual exposure (OR 3.03; 95% CI 2.25–4.07), and receiving antiretroviral therapy (ART) at study sites in Singapore, South Korea, Malaysia, Japan and Vietnam in comparison to Thailand (all OR > 2). Women were less likely to smoke than men (OR 0.11; 95% CI 0.08–0.14). In simulated interventions, smoking cessation demonstrated the greatest impact in reducing CVD and CHD risk and closely approximated the impact of switching from abacavir to an alternate antiretroviral in the reduction of 5-year MI risk. Conclusions: Multiple interventions could reduce CVD, CHD and MI risk in Asian HIV-positive patients, with smoking cessation potentially being the most influential.

AB - Objectives: The aim of the study was to assess the prevalence and characteristics associated with current smoking in an Asian HIV-positive cohort, to calculate the predictive risks of cardiovascular disease (CVD), coronary heart disease (CHD) and myocardial infarction (MI), and to identify the impact that simulated interventions may have. Methods: Logistic regression analysis was used to distinguish associated current smoking characteristics. Five-year predictive risks of CVD, CHD and MI and the impact of simulated interventions were calculated utilizing the Data Collection on Adverse Effects of Anti-HIV Drugs Study (D:A:D) algorithm. Results: Smoking status data were collected from 4274 participants and 1496 of these had sufficient data for simulated intervention calculations. Current smoking prevalence in these two groups was similar (23.2% vs. 19.9%, respectively). Characteristics associated with current smoking included age > 50 years compared with 30–39 years [odds ratio (OR) 0.65; 95% confidence interval (CI) 0.51–0.83], HIV exposure through injecting drug use compared with heterosexual exposure (OR 3.03; 95% CI 2.25–4.07), and receiving antiretroviral therapy (ART) at study sites in Singapore, South Korea, Malaysia, Japan and Vietnam in comparison to Thailand (all OR > 2). Women were less likely to smoke than men (OR 0.11; 95% CI 0.08–0.14). In simulated interventions, smoking cessation demonstrated the greatest impact in reducing CVD and CHD risk and closely approximated the impact of switching from abacavir to an alternate antiretroviral in the reduction of 5-year MI risk. Conclusions: Multiple interventions could reduce CVD, CHD and MI risk in Asian HIV-positive patients, with smoking cessation potentially being the most influential.

UR - http://www.scopus.com/inward/record.url?scp=84978834485&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84978834485&partnerID=8YFLogxK

U2 - 10.1111/hiv.12358

DO - 10.1111/hiv.12358

M3 - Article

VL - 17

SP - 542

EP - 549

JO - HIV Medicine

JF - HIV Medicine

SN - 1464-2662

IS - 7

ER -

Do TC, Boettiger D, Law M, Pujari S, Zhang F, Chaiwarith R et al. Smoking and projected cardiovascular risk in an HIV-positive Asian regional cohort. HIV Medicine. 2016 Aug 1;17(7):542-549. https://doi.org/10.1111/hiv.12358