Snoring and incident chronic kidney disease: A community-based prospective cohort study

Changhyun Lee, Young Su Joo, Sangmi Lee, Shinchan Kang, Joohwan Kim, Ki Heon Nam, Hae Ryong Yun, Jong Hyun Jhee, Hyoungnae Kim, Seung Hyeok Han, Tae Hyun Yoo, Shin Wook Kang, Jung Tak Park

Research output: Contribution to journalArticle

Abstract

Objectives: Previous studies have shown that symptoms of sleep-disordered breathing are associated with metabolic derangements and vascular disease development. However, the relationship between snoring and renal function is not well investigated. The association between snoring and the development of incident chronic kidney disease (CKD) in subjects with normal renal function was evaluated. Design: Prospective cohort study. Setting: Ansung (rural community) and Ansan (urban community) cities. Participants: Community-based cohort participants aged 40-69 years. Methods: A total of 9062 participants in the Ansung-Ansan cohort study were prospectively followed up from 2001 to 2014. The participants were classified into three groups: non-snorer, <1 day/week and ≥1 day/week. The main outcome was incident CKD, which was defined as an estimated glomerular filtration rate of <60 mL/min/1.73 m 2 during the follow-up period. Primary outcome Incident CKD. Results: The mean subject age was 52.0±8.9 years, and 4372 (48.2%) subjects were male. The non-snorer,<1 day/week and ≥1 day/week groups included 3493 (38.5%), 3749 (41.4%), and 1820 (20.1%) subjects, respectively. Metabolic syndrome was more prevalent in the snoring groups than in the non-snoring group. Snoring frequency showed a significant positive relationship with age, waist:hip ratio, fasting glucose, total cholesterol (Tchol) and low-density lipoprotein cholesterol. During a mean follow-up of 8.9 years, 764 (8.4%) subjects developed CKD. Cox proportional hazards model analysis revealed that the risk of CKD development was significantly higher in subjects who snored ≥1 day/week than in non-snorers, even after adjustments for confounding factors (HR 1.23, 95% CI 1.09 to 1.38, p<0.01). Conclusion: Snoring may increase the risk of CKD development in subjects with normal renal function.

Original languageEnglish
Article numbere030671
JournalBMJ open
Volume9
Issue number8
DOIs
Publication statusPublished - 2019 Aug 1

Fingerprint

Snoring
Chronic Renal Insufficiency
Cohort Studies
Prospective Studies
Kidney
Waist-Hip Ratio
Metabolic Diseases
Sleep Apnea Syndromes
Rural Population
Glomerular Filtration Rate
Vascular Diseases
Proportional Hazards Models
LDL Cholesterol
Fasting
Cholesterol
Glucose

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Lee, C., Joo, Y. S., Lee, S., Kang, S., Kim, J., Nam, K. H., ... Park, J. T. (2019). Snoring and incident chronic kidney disease: A community-based prospective cohort study. BMJ open, 9(8), [e030671]. https://doi.org/10.1136/bmjopen-2019-030671
Lee, Changhyun ; Joo, Young Su ; Lee, Sangmi ; Kang, Shinchan ; Kim, Joohwan ; Nam, Ki Heon ; Yun, Hae Ryong ; Jhee, Jong Hyun ; Kim, Hyoungnae ; Han, Seung Hyeok ; Yoo, Tae Hyun ; Kang, Shin Wook ; Park, Jung Tak. / Snoring and incident chronic kidney disease : A community-based prospective cohort study. In: BMJ open. 2019 ; Vol. 9, No. 8.
@article{89b810b253b848ae8ff157efd0afab04,
title = "Snoring and incident chronic kidney disease: A community-based prospective cohort study",
abstract = "Objectives: Previous studies have shown that symptoms of sleep-disordered breathing are associated with metabolic derangements and vascular disease development. However, the relationship between snoring and renal function is not well investigated. The association between snoring and the development of incident chronic kidney disease (CKD) in subjects with normal renal function was evaluated. Design: Prospective cohort study. Setting: Ansung (rural community) and Ansan (urban community) cities. Participants: Community-based cohort participants aged 40-69 years. Methods: A total of 9062 participants in the Ansung-Ansan cohort study were prospectively followed up from 2001 to 2014. The participants were classified into three groups: non-snorer, <1 day/week and ≥1 day/week. The main outcome was incident CKD, which was defined as an estimated glomerular filtration rate of <60 mL/min/1.73 m 2 during the follow-up period. Primary outcome Incident CKD. Results: The mean subject age was 52.0±8.9 years, and 4372 (48.2{\%}) subjects were male. The non-snorer,<1 day/week and ≥1 day/week groups included 3493 (38.5{\%}), 3749 (41.4{\%}), and 1820 (20.1{\%}) subjects, respectively. Metabolic syndrome was more prevalent in the snoring groups than in the non-snoring group. Snoring frequency showed a significant positive relationship with age, waist:hip ratio, fasting glucose, total cholesterol (Tchol) and low-density lipoprotein cholesterol. During a mean follow-up of 8.9 years, 764 (8.4{\%}) subjects developed CKD. Cox proportional hazards model analysis revealed that the risk of CKD development was significantly higher in subjects who snored ≥1 day/week than in non-snorers, even after adjustments for confounding factors (HR 1.23, 95{\%} CI 1.09 to 1.38, p<0.01). Conclusion: Snoring may increase the risk of CKD development in subjects with normal renal function.",
author = "Changhyun Lee and Joo, {Young Su} and Sangmi Lee and Shinchan Kang and Joohwan Kim and Nam, {Ki Heon} and Yun, {Hae Ryong} and Jhee, {Jong Hyun} and Hyoungnae Kim and Han, {Seung Hyeok} and Yoo, {Tae Hyun} and Kang, {Shin Wook} and Park, {Jung Tak}",
year = "2019",
month = "8",
day = "1",
doi = "10.1136/bmjopen-2019-030671",
language = "English",
volume = "9",
journal = "BMJ Open",
issn = "2044-6055",
publisher = "BMJ Publishing Group",
number = "8",

}

Lee, C, Joo, YS, Lee, S, Kang, S, Kim, J, Nam, KH, Yun, HR, Jhee, JH, Kim, H, Han, SH, Yoo, TH, Kang, SW & Park, JT 2019, 'Snoring and incident chronic kidney disease: A community-based prospective cohort study', BMJ open, vol. 9, no. 8, e030671. https://doi.org/10.1136/bmjopen-2019-030671

Snoring and incident chronic kidney disease : A community-based prospective cohort study. / Lee, Changhyun; Joo, Young Su; Lee, Sangmi; Kang, Shinchan; Kim, Joohwan; Nam, Ki Heon; Yun, Hae Ryong; Jhee, Jong Hyun; Kim, Hyoungnae; Han, Seung Hyeok; Yoo, Tae Hyun; Kang, Shin Wook; Park, Jung Tak.

In: BMJ open, Vol. 9, No. 8, e030671, 01.08.2019.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Snoring and incident chronic kidney disease

T2 - A community-based prospective cohort study

AU - Lee, Changhyun

AU - Joo, Young Su

AU - Lee, Sangmi

AU - Kang, Shinchan

AU - Kim, Joohwan

AU - Nam, Ki Heon

AU - Yun, Hae Ryong

AU - Jhee, Jong Hyun

AU - Kim, Hyoungnae

AU - Han, Seung Hyeok

AU - Yoo, Tae Hyun

AU - Kang, Shin Wook

AU - Park, Jung Tak

PY - 2019/8/1

Y1 - 2019/8/1

N2 - Objectives: Previous studies have shown that symptoms of sleep-disordered breathing are associated with metabolic derangements and vascular disease development. However, the relationship between snoring and renal function is not well investigated. The association between snoring and the development of incident chronic kidney disease (CKD) in subjects with normal renal function was evaluated. Design: Prospective cohort study. Setting: Ansung (rural community) and Ansan (urban community) cities. Participants: Community-based cohort participants aged 40-69 years. Methods: A total of 9062 participants in the Ansung-Ansan cohort study were prospectively followed up from 2001 to 2014. The participants were classified into three groups: non-snorer, <1 day/week and ≥1 day/week. The main outcome was incident CKD, which was defined as an estimated glomerular filtration rate of <60 mL/min/1.73 m 2 during the follow-up period. Primary outcome Incident CKD. Results: The mean subject age was 52.0±8.9 years, and 4372 (48.2%) subjects were male. The non-snorer,<1 day/week and ≥1 day/week groups included 3493 (38.5%), 3749 (41.4%), and 1820 (20.1%) subjects, respectively. Metabolic syndrome was more prevalent in the snoring groups than in the non-snoring group. Snoring frequency showed a significant positive relationship with age, waist:hip ratio, fasting glucose, total cholesterol (Tchol) and low-density lipoprotein cholesterol. During a mean follow-up of 8.9 years, 764 (8.4%) subjects developed CKD. Cox proportional hazards model analysis revealed that the risk of CKD development was significantly higher in subjects who snored ≥1 day/week than in non-snorers, even after adjustments for confounding factors (HR 1.23, 95% CI 1.09 to 1.38, p<0.01). Conclusion: Snoring may increase the risk of CKD development in subjects with normal renal function.

AB - Objectives: Previous studies have shown that symptoms of sleep-disordered breathing are associated with metabolic derangements and vascular disease development. However, the relationship between snoring and renal function is not well investigated. The association between snoring and the development of incident chronic kidney disease (CKD) in subjects with normal renal function was evaluated. Design: Prospective cohort study. Setting: Ansung (rural community) and Ansan (urban community) cities. Participants: Community-based cohort participants aged 40-69 years. Methods: A total of 9062 participants in the Ansung-Ansan cohort study were prospectively followed up from 2001 to 2014. The participants were classified into three groups: non-snorer, <1 day/week and ≥1 day/week. The main outcome was incident CKD, which was defined as an estimated glomerular filtration rate of <60 mL/min/1.73 m 2 during the follow-up period. Primary outcome Incident CKD. Results: The mean subject age was 52.0±8.9 years, and 4372 (48.2%) subjects were male. The non-snorer,<1 day/week and ≥1 day/week groups included 3493 (38.5%), 3749 (41.4%), and 1820 (20.1%) subjects, respectively. Metabolic syndrome was more prevalent in the snoring groups than in the non-snoring group. Snoring frequency showed a significant positive relationship with age, waist:hip ratio, fasting glucose, total cholesterol (Tchol) and low-density lipoprotein cholesterol. During a mean follow-up of 8.9 years, 764 (8.4%) subjects developed CKD. Cox proportional hazards model analysis revealed that the risk of CKD development was significantly higher in subjects who snored ≥1 day/week than in non-snorers, even after adjustments for confounding factors (HR 1.23, 95% CI 1.09 to 1.38, p<0.01). Conclusion: Snoring may increase the risk of CKD development in subjects with normal renal function.

UR - http://www.scopus.com/inward/record.url?scp=85070264193&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85070264193&partnerID=8YFLogxK

U2 - 10.1136/bmjopen-2019-030671

DO - 10.1136/bmjopen-2019-030671

M3 - Article

C2 - 31383712

AN - SCOPUS:85070264193

VL - 9

JO - BMJ Open

JF - BMJ Open

SN - 2044-6055

IS - 8

M1 - e030671

ER -