Sodium picosulfate with magnesium citrate (SPMC) plus laxative is a good alternative to conventional large volume polyethylene glycol in bowel preparation

A multicenter randomized single-blinded trial

Hyun Gun Kim, Kyu Chan Huh, Hoon Sup Koo, Seong Eun Kim, Jin Oh Kim, Tae Il Kim, Hyunsoo Kim, Seung Jae Myung, Dong Il Park, Jeong Eun Shin, Dong Hoon Yang, Suck Ho Lee, Ji Sung Lee, Chang Kyun Lee, Dong Kyung Chang, Young Eun Joo, Jae Myung Cha, Sung Pil Hong, Hyo Jong Kim

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Background/Aims: We investigated whether sodium picosulfate with magnesium citrate (SPMC) plus bisacodyl compares favorably with conventional polyethylene glycol (PEG) with respect to bowel cleansing adequacy, compliance, and safety. Methods: We performed a multicenter, prospective, single-blinded study in outpatients undergoing daytime colonoscopies. Patients were randomized into a split preparation SPMC/bisacodyl group and a conventional split PEG group. We compared preparation adequacy using the Boston bowel preparation scale (BBPS), ease of use using a modified Likert scale (LS), compliance/satisfaction level using a visual analogue scale (VAS), and safety by monitoring adverse events during the colonoscopy between the two groups. Results: A total of 365 patients were evaluated by intention to treat (ITT) analysis, and 319 were evaluated by per protocol (PP) population analysis (153 for SPMC/bisacodyl, 166 for PEG). The mean total BBPS score was not different between the two groups in both the ITT and PP analyses (p>0.05). The mean VAS score for satisfaction and LS score for the ease of use were higher in the SPMC/bisacodyl group (p<0.001). The adverse event rate was lower in the SPMC/bisacodyl group than in the PEG group (p<0.05). Conclusions: The SPMC/bisacodyl treatment was comparable to conventional PEG with respect to bowel preparation adequacy and superior with respect to compliance, satisfaction, and safety.

Original languageEnglish
Pages (from-to)494-501
Number of pages8
JournalGut and liver
Volume9
Issue number4
DOIs
Publication statusPublished - 2015 Jul 1

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Bisacodyl
Laxatives
Compliance
Colonoscopy
Visual Analog Scale
Safety
Intention to Treat Analysis
magnesium citrate
picosulfate sodium
Outpatients

All Science Journal Classification (ASJC) codes

  • Hepatology
  • Gastroenterology

Cite this

Kim, Hyun Gun ; Huh, Kyu Chan ; Koo, Hoon Sup ; Kim, Seong Eun ; Kim, Jin Oh ; Kim, Tae Il ; Kim, Hyunsoo ; Myung, Seung Jae ; Park, Dong Il ; Shin, Jeong Eun ; Yang, Dong Hoon ; Lee, Suck Ho ; Lee, Ji Sung ; Lee, Chang Kyun ; Chang, Dong Kyung ; Joo, Young Eun ; Cha, Jae Myung ; Hong, Sung Pil ; Kim, Hyo Jong. / Sodium picosulfate with magnesium citrate (SPMC) plus laxative is a good alternative to conventional large volume polyethylene glycol in bowel preparation : A multicenter randomized single-blinded trial. In: Gut and liver. 2015 ; Vol. 9, No. 4. pp. 494-501.
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title = "Sodium picosulfate with magnesium citrate (SPMC) plus laxative is a good alternative to conventional large volume polyethylene glycol in bowel preparation: A multicenter randomized single-blinded trial",
abstract = "Background/Aims: We investigated whether sodium picosulfate with magnesium citrate (SPMC) plus bisacodyl compares favorably with conventional polyethylene glycol (PEG) with respect to bowel cleansing adequacy, compliance, and safety. Methods: We performed a multicenter, prospective, single-blinded study in outpatients undergoing daytime colonoscopies. Patients were randomized into a split preparation SPMC/bisacodyl group and a conventional split PEG group. We compared preparation adequacy using the Boston bowel preparation scale (BBPS), ease of use using a modified Likert scale (LS), compliance/satisfaction level using a visual analogue scale (VAS), and safety by monitoring adverse events during the colonoscopy between the two groups. Results: A total of 365 patients were evaluated by intention to treat (ITT) analysis, and 319 were evaluated by per protocol (PP) population analysis (153 for SPMC/bisacodyl, 166 for PEG). The mean total BBPS score was not different between the two groups in both the ITT and PP analyses (p>0.05). The mean VAS score for satisfaction and LS score for the ease of use were higher in the SPMC/bisacodyl group (p<0.001). The adverse event rate was lower in the SPMC/bisacodyl group than in the PEG group (p<0.05). Conclusions: The SPMC/bisacodyl treatment was comparable to conventional PEG with respect to bowel preparation adequacy and superior with respect to compliance, satisfaction, and safety.",
author = "Kim, {Hyun Gun} and Huh, {Kyu Chan} and Koo, {Hoon Sup} and Kim, {Seong Eun} and Kim, {Jin Oh} and Kim, {Tae Il} and Hyunsoo Kim and Myung, {Seung Jae} and Park, {Dong Il} and Shin, {Jeong Eun} and Yang, {Dong Hoon} and Lee, {Suck Ho} and Lee, {Ji Sung} and Lee, {Chang Kyun} and Chang, {Dong Kyung} and Joo, {Young Eun} and Cha, {Jae Myung} and Hong, {Sung Pil} and Kim, {Hyo Jong}",
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Kim, HG, Huh, KC, Koo, HS, Kim, SE, Kim, JO, Kim, TI, Kim, H, Myung, SJ, Park, DI, Shin, JE, Yang, DH, Lee, SH, Lee, JS, Lee, CK, Chang, DK, Joo, YE, Cha, JM, Hong, SP & Kim, HJ 2015, 'Sodium picosulfate with magnesium citrate (SPMC) plus laxative is a good alternative to conventional large volume polyethylene glycol in bowel preparation: A multicenter randomized single-blinded trial', Gut and liver, vol. 9, no. 4, pp. 494-501. https://doi.org/10.5009/gnl14010

Sodium picosulfate with magnesium citrate (SPMC) plus laxative is a good alternative to conventional large volume polyethylene glycol in bowel preparation : A multicenter randomized single-blinded trial. / Kim, Hyun Gun; Huh, Kyu Chan; Koo, Hoon Sup; Kim, Seong Eun; Kim, Jin Oh; Kim, Tae Il; Kim, Hyunsoo; Myung, Seung Jae; Park, Dong Il; Shin, Jeong Eun; Yang, Dong Hoon; Lee, Suck Ho; Lee, Ji Sung; Lee, Chang Kyun; Chang, Dong Kyung; Joo, Young Eun; Cha, Jae Myung; Hong, Sung Pil; Kim, Hyo Jong.

In: Gut and liver, Vol. 9, No. 4, 01.07.2015, p. 494-501.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Sodium picosulfate with magnesium citrate (SPMC) plus laxative is a good alternative to conventional large volume polyethylene glycol in bowel preparation

T2 - A multicenter randomized single-blinded trial

AU - Kim, Hyun Gun

AU - Huh, Kyu Chan

AU - Koo, Hoon Sup

AU - Kim, Seong Eun

AU - Kim, Jin Oh

AU - Kim, Tae Il

AU - Kim, Hyunsoo

AU - Myung, Seung Jae

AU - Park, Dong Il

AU - Shin, Jeong Eun

AU - Yang, Dong Hoon

AU - Lee, Suck Ho

AU - Lee, Ji Sung

AU - Lee, Chang Kyun

AU - Chang, Dong Kyung

AU - Joo, Young Eun

AU - Cha, Jae Myung

AU - Hong, Sung Pil

AU - Kim, Hyo Jong

PY - 2015/7/1

Y1 - 2015/7/1

N2 - Background/Aims: We investigated whether sodium picosulfate with magnesium citrate (SPMC) plus bisacodyl compares favorably with conventional polyethylene glycol (PEG) with respect to bowel cleansing adequacy, compliance, and safety. Methods: We performed a multicenter, prospective, single-blinded study in outpatients undergoing daytime colonoscopies. Patients were randomized into a split preparation SPMC/bisacodyl group and a conventional split PEG group. We compared preparation adequacy using the Boston bowel preparation scale (BBPS), ease of use using a modified Likert scale (LS), compliance/satisfaction level using a visual analogue scale (VAS), and safety by monitoring adverse events during the colonoscopy between the two groups. Results: A total of 365 patients were evaluated by intention to treat (ITT) analysis, and 319 were evaluated by per protocol (PP) population analysis (153 for SPMC/bisacodyl, 166 for PEG). The mean total BBPS score was not different between the two groups in both the ITT and PP analyses (p>0.05). The mean VAS score for satisfaction and LS score for the ease of use were higher in the SPMC/bisacodyl group (p<0.001). The adverse event rate was lower in the SPMC/bisacodyl group than in the PEG group (p<0.05). Conclusions: The SPMC/bisacodyl treatment was comparable to conventional PEG with respect to bowel preparation adequacy and superior with respect to compliance, satisfaction, and safety.

AB - Background/Aims: We investigated whether sodium picosulfate with magnesium citrate (SPMC) plus bisacodyl compares favorably with conventional polyethylene glycol (PEG) with respect to bowel cleansing adequacy, compliance, and safety. Methods: We performed a multicenter, prospective, single-blinded study in outpatients undergoing daytime colonoscopies. Patients were randomized into a split preparation SPMC/bisacodyl group and a conventional split PEG group. We compared preparation adequacy using the Boston bowel preparation scale (BBPS), ease of use using a modified Likert scale (LS), compliance/satisfaction level using a visual analogue scale (VAS), and safety by monitoring adverse events during the colonoscopy between the two groups. Results: A total of 365 patients were evaluated by intention to treat (ITT) analysis, and 319 were evaluated by per protocol (PP) population analysis (153 for SPMC/bisacodyl, 166 for PEG). The mean total BBPS score was not different between the two groups in both the ITT and PP analyses (p>0.05). The mean VAS score for satisfaction and LS score for the ease of use were higher in the SPMC/bisacodyl group (p<0.001). The adverse event rate was lower in the SPMC/bisacodyl group than in the PEG group (p<0.05). Conclusions: The SPMC/bisacodyl treatment was comparable to conventional PEG with respect to bowel preparation adequacy and superior with respect to compliance, satisfaction, and safety.

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U2 - 10.5009/gnl14010

DO - 10.5009/gnl14010

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VL - 9

SP - 494

EP - 501

JO - Gut and Liver

JF - Gut and Liver

SN - 1976-2283

IS - 4

ER -