Sodium picosulfate with magnesium citrate (SPMC) plus laxative is a good alternative to conventional large volume polyethylene glycol in bowel preparation: A multicenter randomized single-blinded trial

Hyun Gun Kim, Kyu Chan Huh, Hoon Sup Koo, Seong Eun Kim, Jin Oh Kim, Tae Il Kim, Hyun Soo Kim, Seung Jae Myung, Dong Il Park, Jeong Eun Shin, Dong Hoon Yang, Suck Ho Lee, Ji Sung Lee, Chang Kyun Lee, Dong Kyung Chang, Young Eun Joo, Jae Myung Cha, Sung Pil Hong, Hyo Jong Kim

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Abstract

Background/Aims: We investigated whether sodium picosulfate with magnesium citrate (SPMC) plus bisacodyl compares favorably with conventional polyethylene glycol (PEG) with respect to bowel cleansing adequacy, compliance, and safety. Methods: We performed a multicenter, prospective, single-blinded study in outpatients undergoing daytime colonoscopies. Patients were randomized into a split preparation SPMC/bisacodyl group and a conventional split PEG group. We compared preparation adequacy using the Boston bowel preparation scale (BBPS), ease of use using a modified Likert scale (LS), compliance/satisfaction level using a visual analogue scale (VAS), and safety by monitoring adverse events during the colonoscopy between the two groups. Results: A total of 365 patients were evaluated by intention to treat (ITT) analysis, and 319 were evaluated by per protocol (PP) population analysis (153 for SPMC/bisacodyl, 166 for PEG). The mean total BBPS score was not different between the two groups in both the ITT and PP analyses (p>0.05). The mean VAS score for satisfaction and LS score for the ease of use were higher in the SPMC/bisacodyl group (p<0.001). The adverse event rate was lower in the SPMC/bisacodyl group than in the PEG group (p<0.05). Conclusions: The SPMC/bisacodyl treatment was comparable to conventional PEG with respect to bowel preparation adequacy and superior with respect to compliance, satisfaction, and safety.

Original languageEnglish
Pages (from-to)494-501
Number of pages8
JournalGut and liver
Volume9
Issue number4
DOIs
Publication statusPublished - 2015 Jul 1

All Science Journal Classification (ASJC) codes

  • Hepatology
  • Gastroenterology

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    Kim, H. G., Huh, K. C., Koo, H. S., Kim, S. E., Kim, J. O., Kim, T. I., Kim, H. S., Myung, S. J., Park, D. I., Shin, J. E., Yang, D. H., Lee, S. H., Lee, J. S., Lee, C. K., Chang, D. K., Joo, Y. E., Cha, J. M., Hong, S. P., & Kim, H. J. (2015). Sodium picosulfate with magnesium citrate (SPMC) plus laxative is a good alternative to conventional large volume polyethylene glycol in bowel preparation: A multicenter randomized single-blinded trial. Gut and liver, 9(4), 494-501. https://doi.org/10.5009/gnl14010