Soft network composite materials with deterministic and bio-inspired designs

Kyung In Jang, Ha Uk Chung, Sheng Xu, Chi Hwan Lee, Haiwen Luan, Jaewoong Jeong, Huanyu Cheng, Gwang Tae Kim, Sang Youn Han, Jung Woo Lee, Jeonghyun Kim, Moongee Cho, Fuxing Miao, Yiyuan Yang, Han Na Jung, Matthew Flavin, Howard Liu, Gil Woo Kong, Ki Jun Yu, Sang Il Rhee & 10 others Jeahoon Chung, Byunggik Kim, Jean Won Kwak, Myoung Hee Yun, Jin Young Kim, Young Min Song, Ungyu Paik, Yihui Zhang, Yonggang Huang, John A. Rogers

Research output: Contribution to journalArticle

160 Citations (Scopus)

Abstract

Hard and soft structural composites found in biology provide inspiration for the design of advanced synthetic materials. Many examples of bio-inspired hard materials can be found in the literature; far less attention has been devoted to soft systems. Here we introduce deterministic routes to low-modulus thin film materials with stress/strain responses that can be tailored precisely to match the non-linear properties of biological tissues, with application opportunities that range from soft biomedical devices to constructs for tissue engineering. The approach combines a low-modulus matrix with an open, stretchable network as a structural reinforcement that can yield classes of composites with a wide range of desired mechanical responses, including anisotropic, spatially heterogeneous, hierarchical and self-similar designs. Demonstrative application examples in thin, skin-mounted electrophysiological sensors with mechanics precisely matched to the human epidermis and in soft, hydrogel-based vehicles for triggered drug release suggest their broad potential uses in biomedical devices.

Original languageEnglish
Article number6566
JournalNature communications
Volume6
DOIs
Publication statusPublished - 2015 Mar 18

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inspiration
epidermis
Equipment and Supplies
composite materials
tissue engineering
Hydrogel
Composite materials
Tissue Engineering
reinforcement
Mechanics
biology
Epidermis
vehicles
drugs
routes
Tissue engineering
Skin
sensors
Reinforcement
matrices

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Physics and Astronomy(all)

Cite this

Jang, K. I., Chung, H. U., Xu, S., Lee, C. H., Luan, H., Jeong, J., ... Rogers, J. A. (2015). Soft network composite materials with deterministic and bio-inspired designs. Nature communications, 6, [6566]. https://doi.org/10.1038/ncomms7566
Jang, Kyung In ; Chung, Ha Uk ; Xu, Sheng ; Lee, Chi Hwan ; Luan, Haiwen ; Jeong, Jaewoong ; Cheng, Huanyu ; Kim, Gwang Tae ; Han, Sang Youn ; Lee, Jung Woo ; Kim, Jeonghyun ; Cho, Moongee ; Miao, Fuxing ; Yang, Yiyuan ; Jung, Han Na ; Flavin, Matthew ; Liu, Howard ; Kong, Gil Woo ; Yu, Ki Jun ; Rhee, Sang Il ; Chung, Jeahoon ; Kim, Byunggik ; Kwak, Jean Won ; Yun, Myoung Hee ; Kim, Jin Young ; Song, Young Min ; Paik, Ungyu ; Zhang, Yihui ; Huang, Yonggang ; Rogers, John A. / Soft network composite materials with deterministic and bio-inspired designs. In: Nature communications. 2015 ; Vol. 6.
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abstract = "Hard and soft structural composites found in biology provide inspiration for the design of advanced synthetic materials. Many examples of bio-inspired hard materials can be found in the literature; far less attention has been devoted to soft systems. Here we introduce deterministic routes to low-modulus thin film materials with stress/strain responses that can be tailored precisely to match the non-linear properties of biological tissues, with application opportunities that range from soft biomedical devices to constructs for tissue engineering. The approach combines a low-modulus matrix with an open, stretchable network as a structural reinforcement that can yield classes of composites with a wide range of desired mechanical responses, including anisotropic, spatially heterogeneous, hierarchical and self-similar designs. Demonstrative application examples in thin, skin-mounted electrophysiological sensors with mechanics precisely matched to the human epidermis and in soft, hydrogel-based vehicles for triggered drug release suggest their broad potential uses in biomedical devices.",
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Jang, KI, Chung, HU, Xu, S, Lee, CH, Luan, H, Jeong, J, Cheng, H, Kim, GT, Han, SY, Lee, JW, Kim, J, Cho, M, Miao, F, Yang, Y, Jung, HN, Flavin, M, Liu, H, Kong, GW, Yu, KJ, Rhee, SI, Chung, J, Kim, B, Kwak, JW, Yun, MH, Kim, JY, Song, YM, Paik, U, Zhang, Y, Huang, Y & Rogers, JA 2015, 'Soft network composite materials with deterministic and bio-inspired designs', Nature communications, vol. 6, 6566. https://doi.org/10.1038/ncomms7566

Soft network composite materials with deterministic and bio-inspired designs. / Jang, Kyung In; Chung, Ha Uk; Xu, Sheng; Lee, Chi Hwan; Luan, Haiwen; Jeong, Jaewoong; Cheng, Huanyu; Kim, Gwang Tae; Han, Sang Youn; Lee, Jung Woo; Kim, Jeonghyun; Cho, Moongee; Miao, Fuxing; Yang, Yiyuan; Jung, Han Na; Flavin, Matthew; Liu, Howard; Kong, Gil Woo; Yu, Ki Jun; Rhee, Sang Il; Chung, Jeahoon; Kim, Byunggik; Kwak, Jean Won; Yun, Myoung Hee; Kim, Jin Young; Song, Young Min; Paik, Ungyu; Zhang, Yihui; Huang, Yonggang; Rogers, John A.

In: Nature communications, Vol. 6, 6566, 18.03.2015.

Research output: Contribution to journalArticle

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AU - Jang, Kyung In

AU - Chung, Ha Uk

AU - Xu, Sheng

AU - Lee, Chi Hwan

AU - Luan, Haiwen

AU - Jeong, Jaewoong

AU - Cheng, Huanyu

AU - Kim, Gwang Tae

AU - Han, Sang Youn

AU - Lee, Jung Woo

AU - Kim, Jeonghyun

AU - Cho, Moongee

AU - Miao, Fuxing

AU - Yang, Yiyuan

AU - Jung, Han Na

AU - Flavin, Matthew

AU - Liu, Howard

AU - Kong, Gil Woo

AU - Yu, Ki Jun

AU - Rhee, Sang Il

AU - Chung, Jeahoon

AU - Kim, Byunggik

AU - Kwak, Jean Won

AU - Yun, Myoung Hee

AU - Kim, Jin Young

AU - Song, Young Min

AU - Paik, Ungyu

AU - Zhang, Yihui

AU - Huang, Yonggang

AU - Rogers, John A.

PY - 2015/3/18

Y1 - 2015/3/18

N2 - Hard and soft structural composites found in biology provide inspiration for the design of advanced synthetic materials. Many examples of bio-inspired hard materials can be found in the literature; far less attention has been devoted to soft systems. Here we introduce deterministic routes to low-modulus thin film materials with stress/strain responses that can be tailored precisely to match the non-linear properties of biological tissues, with application opportunities that range from soft biomedical devices to constructs for tissue engineering. The approach combines a low-modulus matrix with an open, stretchable network as a structural reinforcement that can yield classes of composites with a wide range of desired mechanical responses, including anisotropic, spatially heterogeneous, hierarchical and self-similar designs. Demonstrative application examples in thin, skin-mounted electrophysiological sensors with mechanics precisely matched to the human epidermis and in soft, hydrogel-based vehicles for triggered drug release suggest their broad potential uses in biomedical devices.

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