Soft, skin-interfaced microfluidic systems with integrated immunoassays, fluorometric sensors, and impedance measurement capabilities

Sungbong Kim, Boram Lee, Jonathan T. Reeder, Seon Hee Seo, Sung Uk Lee, Aurélie Hourlier-Fargette, Joonchul Shin, Yurina Sekine, Hyoyoung Jeong, Yong Suk Oh, Alexander J. Aranyosi, Stephen P. Lee, Jeffrey B. Model, Geumbee Lee, Min Ho Seo, Sung Soo Kwak, Seongbin Jo, Gyungmin Park, Sunghyun Han, Inkyu ParkHyo Il Jung, Roozbeh Ghaffari, Jahyun Koo, Paul V. Braun, John A. Rogers

Research output: Contribution to journalArticlepeer-review

50 Citations (Scopus)


Soft microfluidic systems that capture, store, and perform biomarker analysis of microliter volumes of sweat, in situ, as it emerges from the surface of the skin, represent an emerging class of wearable technology with powerful capabilities that complement those of traditional biophysical sensing devices. Recent work establishes applications in the real-time characterization of sweat dynamics and sweat chemistry in the context of sports performance and healthcare diagnostics. This paper presents a collection of advances in biochemical sensors and microfluidic designs that support multimodal operation in the monitoring of physiological signatures directly correlated to physical and mental stresses. These wireless, battery-free, skin-interfaced devices combine lateral flow immunoassays for cortisol, fluorometric assays for glucose and ascorbic acid (vitamin C), and digital tracking of skin galvanic responses. Systematic benchtop evaluations and field studies on human subjects highlight the key features of this platform for the continuous, noninvasive monitoring of biochemical and biophysical correlates of the stress state.

Original languageEnglish
Pages (from-to)27906-27915
Number of pages10
JournalProceedings of the National Academy of Sciences of the United States of America
Issue number45
Publication statusPublished - 2020 Nov 10

Bibliographical note

Funding Information:
ACKNOWLEDGMENTS. J.K. acknowledges grant support from National Research Foundation of Korea (NRF-2020R1F1A1068083). R.G., A.J.A., and J.B.M. acknowledge funding support from the Leo Science and Tech Hub. S.H.S. acknowledges grant support from the Primary Research Program (20A01021) of the Korea Electrotechnology Research Institute. This work utilized the Northwestern University Micro/Nano Fabrication Facility, which was partially supported by Soft and Hybrid Nanotechnology Experimental Resource (NSF ECCS-1542205).

Publisher Copyright:
© 2020 National Academy of Sciences. All rights reserved.

All Science Journal Classification (ASJC) codes

  • General


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