Soft microfluidic systems that capture, store, and perform biomarker analysis of microliter volumes of sweat, in situ, as it emerges from the surface of the skin, represent an emerging class of wearable technology with powerful capabilities that complement those of traditional biophysical sensing devices. Recent work establishes applications in the real-time characterization of sweat dynamics and sweat chemistry in the context of sports performance and healthcare diagnostics. This paper presents a collection of advances in biochemical sensors and microfluidic designs that support multimodal operation in the monitoring of physiological signatures directly correlated to physical and mental stresses. These wireless, battery-free, skin-interfaced devices combine lateral flow immunoassays for cortisol, fluorometric assays for glucose and ascorbic acid (vitamin C), and digital tracking of skin galvanic responses. Systematic benchtop evaluations and field studies on human subjects highlight the key features of this platform for the continuous, noninvasive monitoring of biochemical and biophysical correlates of the stress state.
|Number of pages||10|
|Journal||Proceedings of the National Academy of Sciences of the United States of America|
|Publication status||Published - 2020 Nov 10|
Bibliographical noteFunding Information:
ACKNOWLEDGMENTS. J.K. acknowledges grant support from National Research Foundation of Korea (NRF-2020R1F1A1068083). R.G., A.J.A., and J.B.M. acknowledge funding support from the Leo Science and Tech Hub. S.H.S. acknowledges grant support from the Primary Research Program (20A01021) of the Korea Electrotechnology Research Institute. This work utilized the Northwestern University Micro/Nano Fabrication Facility, which was partially supported by Soft and Hybrid Nanotechnology Experimental Resource (NSF ECCS-1542205).
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