Soft subdermal implant capable of wireless battery charging and programmable controls for applications in optogenetics

Choong Yeon Kim; Min Jeong Ku; Raza Qazi; Hong Jae Nam; Jong Woo Park; Kum Seok Nam; Shane Oh; Inho Kang; Jae Hyung Jang; Wha Young Kim; Jeong Hoon Kim; Jae Woong Jeong

doi:10.1038/s41467-020-20803-y

Soft subdermal implant capable of wireless battery charging and programmable controls for applications in optogenetics

Choong Yeon Kim, Min Jeong Ku, Raza Qazi, Hong Jae Nam, Jong Woo Park, Kum Seok Nam, Shane Oh, Inho Kang, Jae Hyung Jang, Wha Young Kim, Jeong Hoon Kim, Jae Woong Jeong

Department of Chemical and Biomolecular Engineering

Research output: Contribution to journal › Article › peer-review

43 Citations (Scopus)

Abstract

Optogenetics is a powerful technique that allows target-specific spatiotemporal manipulation of neuronal activity for dissection of neural circuits and therapeutic interventions. Recent advances in wireless optogenetics technologies have enabled investigation of brain circuits in more natural conditions by releasing animals from tethered optical fibers. However, current wireless implants, which are largely based on battery-powered or battery-free designs, still limit the full potential of in vivo optogenetics in freely moving animals by requiring intermittent battery replacement or a special, bulky wireless power transfer system for continuous device operation, respectively. To address these limitations, here we present a wirelessly rechargeable, fully implantable, soft optoelectronic system that can be remotely and selectively controlled using a smartphone. Combining advantageous features of both battery-powered and battery-free designs, this device system enables seamless full implantation into animals, reliable ubiquitous operation, and intervention-free wireless charging, all of which are desired for chronic in vivo optogenetics. Successful demonstration of the unique capabilities of this device in freely behaving rats forecasts its broad and practical utilities in various neuroscience research and clinical applications.

Original language	English
Article number	535
Journal	Nature communications
Volume	12
Issue number	1
DOIs	https://doi.org/10.1038/s41467-020-20803-y
Publication status	Published - 2021 Dec

Bibliographical note

Funding Information:
This work was supported by the Basic Research Lab Program (2018R1A4A1025230), the Basic Science Research Program (2018R1C1B6001706), and BK21 Plus Program through the National Research Foundation of Korea funded by the Ministry of Science and ICT. This work was also supported by the KAIST-funded Global Singularity Research Program for 2020. We thank ANSYS Korea (ANSYS Inc.) for providing the technical support to use the commercial software ANSYS HFSS.

Publisher Copyright:
© 2021, The Author(s).

All Science Journal Classification (ASJC) codes

Chemistry(all)
Biochemistry, Genetics and Molecular Biology(all)
Physics and Astronomy(all)

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10.1038/s41467-020-20803-y

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title = "Soft subdermal implant capable of wireless battery charging and programmable controls for applications in optogenetics",

abstract = "Optogenetics is a powerful technique that allows target-specific spatiotemporal manipulation of neuronal activity for dissection of neural circuits and therapeutic interventions. Recent advances in wireless optogenetics technologies have enabled investigation of brain circuits in more natural conditions by releasing animals from tethered optical fibers. However, current wireless implants, which are largely based on battery-powered or battery-free designs, still limit the full potential of in vivo optogenetics in freely moving animals by requiring intermittent battery replacement or a special, bulky wireless power transfer system for continuous device operation, respectively. To address these limitations, here we present a wirelessly rechargeable, fully implantable, soft optoelectronic system that can be remotely and selectively controlled using a smartphone. Combining advantageous features of both battery-powered and battery-free designs, this device system enables seamless full implantation into animals, reliable ubiquitous operation, and intervention-free wireless charging, all of which are desired for chronic in vivo optogenetics. Successful demonstration of the unique capabilities of this device in freely behaving rats forecasts its broad and practical utilities in various neuroscience research and clinical applications.",

author = "Kim, {Choong Yeon} and Ku, {Min Jeong} and Raza Qazi and Nam, {Hong Jae} and Park, {Jong Woo} and Nam, {Kum Seok} and Shane Oh and Inho Kang and Jang, {Jae Hyung} and Kim, {Wha Young} and Kim, {Jeong Hoon} and Jeong, {Jae Woong}",

note = "Funding Information: This work was supported by the Basic Research Lab Program (2018R1A4A1025230), the Basic Science Research Program (2018R1C1B6001706), and BK21 Plus Program through the National Research Foundation of Korea funded by the Ministry of Science and ICT. This work was also supported by the KAIST-funded Global Singularity Research Program for 2020. We thank ANSYS Korea (ANSYS Inc.) for providing the technical support to use the commercial software ANSYS HFSS. Publisher Copyright: {\textcopyright} 2021, The Author(s).",

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AU - Kim, Choong Yeon

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AU - Nam, Hong Jae

AU - Park, Jong Woo

AU - Nam, Kum Seok

AU - Oh, Shane

AU - Kang, Inho

AU - Jang, Jae Hyung

AU - Kim, Wha Young

AU - Kim, Jeong Hoon

AU - Jeong, Jae Woong

N1 - Funding Information: This work was supported by the Basic Research Lab Program (2018R1A4A1025230), the Basic Science Research Program (2018R1C1B6001706), and BK21 Plus Program through the National Research Foundation of Korea funded by the Ministry of Science and ICT. This work was also supported by the KAIST-funded Global Singularity Research Program for 2020. We thank ANSYS Korea (ANSYS Inc.) for providing the technical support to use the commercial software ANSYS HFSS. Publisher Copyright: © 2021, The Author(s).

PY - 2021/12

Y1 - 2021/12

N2 - Optogenetics is a powerful technique that allows target-specific spatiotemporal manipulation of neuronal activity for dissection of neural circuits and therapeutic interventions. Recent advances in wireless optogenetics technologies have enabled investigation of brain circuits in more natural conditions by releasing animals from tethered optical fibers. However, current wireless implants, which are largely based on battery-powered or battery-free designs, still limit the full potential of in vivo optogenetics in freely moving animals by requiring intermittent battery replacement or a special, bulky wireless power transfer system for continuous device operation, respectively. To address these limitations, here we present a wirelessly rechargeable, fully implantable, soft optoelectronic system that can be remotely and selectively controlled using a smartphone. Combining advantageous features of both battery-powered and battery-free designs, this device system enables seamless full implantation into animals, reliable ubiquitous operation, and intervention-free wireless charging, all of which are desired for chronic in vivo optogenetics. Successful demonstration of the unique capabilities of this device in freely behaving rats forecasts its broad and practical utilities in various neuroscience research and clinical applications.

AB - Optogenetics is a powerful technique that allows target-specific spatiotemporal manipulation of neuronal activity for dissection of neural circuits and therapeutic interventions. Recent advances in wireless optogenetics technologies have enabled investigation of brain circuits in more natural conditions by releasing animals from tethered optical fibers. However, current wireless implants, which are largely based on battery-powered or battery-free designs, still limit the full potential of in vivo optogenetics in freely moving animals by requiring intermittent battery replacement or a special, bulky wireless power transfer system for continuous device operation, respectively. To address these limitations, here we present a wirelessly rechargeable, fully implantable, soft optoelectronic system that can be remotely and selectively controlled using a smartphone. Combining advantageous features of both battery-powered and battery-free designs, this device system enables seamless full implantation into animals, reliable ubiquitous operation, and intervention-free wireless charging, all of which are desired for chronic in vivo optogenetics. Successful demonstration of the unique capabilities of this device in freely behaving rats forecasts its broad and practical utilities in various neuroscience research and clinical applications.

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Soft subdermal implant capable of wireless battery charging and programmable controls for applications in optogenetics

Abstract

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