Optogenetics is a powerful technique that allows target-specific spatiotemporal manipulation of neuronal activity for dissection of neural circuits and therapeutic interventions. Recent advances in wireless optogenetics technologies have enabled investigation of brain circuits in more natural conditions by releasing animals from tethered optical fibers. However, current wireless implants, which are largely based on battery-powered or battery-free designs, still limit the full potential of in vivo optogenetics in freely moving animals by requiring intermittent battery replacement or a special, bulky wireless power transfer system for continuous device operation, respectively. To address these limitations, here we present a wirelessly rechargeable, fully implantable, soft optoelectronic system that can be remotely and selectively controlled using a smartphone. Combining advantageous features of both battery-powered and battery-free designs, this device system enables seamless full implantation into animals, reliable ubiquitous operation, and intervention-free wireless charging, all of which are desired for chronic in vivo optogenetics. Successful demonstration of the unique capabilities of this device in freely behaving rats forecasts its broad and practical utilities in various neuroscience research and clinical applications.
|Publication status||Published - 2021 Dec|
Bibliographical noteFunding Information:
This work was supported by the Basic Research Lab Program (2018R1A4A1025230), the Basic Science Research Program (2018R1C1B6001706), and BK21 Plus Program through the National Research Foundation of Korea funded by the Ministry of Science and ICT. This work was also supported by the KAIST-funded Global Singularity Research Program for 2020. We thank ANSYS Korea (ANSYS Inc.) for providing the technical support to use the commercial software ANSYS HFSS.
© 2021, The Author(s).
All Science Journal Classification (ASJC) codes
- Biochemistry, Genetics and Molecular Biology(all)
- Physics and Astronomy(all)