Abstract
We introduce a novel solid-phase colorimetric sensor facilely fabricated by loading unmodified gold nanoparticles into poly(oligo(ethylene glycol)methacrylate) (POEGMA) brushes grown on glass. Our work reports the first synergistic combination of metallic nanoparticles acting as a colorimetric sensing module with a nonfouling polymer matrix acting both as a nonrigid scaffold and a screen to reduce interference from nontarget molecules. In addition, as the nanocomposite is formed on a transparent substrate, solid-phase detection can be performed in the same manner as in the solution-phase. We demonstrate the use of this unique platform for label-free lead detection based on the release of gold nanoparticles from the polymer brush upon exposure to lead ions. An ultralow limit-of-detection of 25 pM (S/N = 3) and a dynamic range of 100 pM to 100 nM (R2 = 0.987) are achieved. Furthermore, the detection is up to 1000-fold more selective to lead over other common heavy metal ions.
| Original language | English |
|---|---|
| Pages (from-to) | 4094-4099 |
| Number of pages | 6 |
| Journal | Analytical Chemistry |
| Volume | 85 |
| Issue number | 8 |
| DOIs | |
| Publication status | Published - 2013 Apr 16 |
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All Science Journal Classification (ASJC) codes
- Analytical Chemistry
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Solid-phase colorimetric sensor based on gold nanoparticle-loaded polymer brushes : Lead detection as a case study. / Ferhan, Abdul Rahim; Guo, Longhua; Zhou, Xiaodong; Chen, Peng; Hong, Seungpyo; Kim, Dong Hwan.
In: Analytical Chemistry, Vol. 85, No. 8, 16.04.2013, p. 4094-4099.Research output: Contribution to journal › Article
TY - JOUR
T1 - Solid-phase colorimetric sensor based on gold nanoparticle-loaded polymer brushes
T2 - Lead detection as a case study
AU - Ferhan, Abdul Rahim
AU - Guo, Longhua
AU - Zhou, Xiaodong
AU - Chen, Peng
AU - Hong, Seungpyo
AU - Kim, Dong Hwan
PY - 2013/4/16
Y1 - 2013/4/16
N2 - We introduce a novel solid-phase colorimetric sensor facilely fabricated by loading unmodified gold nanoparticles into poly(oligo(ethylene glycol)methacrylate) (POEGMA) brushes grown on glass. Our work reports the first synergistic combination of metallic nanoparticles acting as a colorimetric sensing module with a nonfouling polymer matrix acting both as a nonrigid scaffold and a screen to reduce interference from nontarget molecules. In addition, as the nanocomposite is formed on a transparent substrate, solid-phase detection can be performed in the same manner as in the solution-phase. We demonstrate the use of this unique platform for label-free lead detection based on the release of gold nanoparticles from the polymer brush upon exposure to lead ions. An ultralow limit-of-detection of 25 pM (S/N = 3) and a dynamic range of 100 pM to 100 nM (R2 = 0.987) are achieved. Furthermore, the detection is up to 1000-fold more selective to lead over other common heavy metal ions.
AB - We introduce a novel solid-phase colorimetric sensor facilely fabricated by loading unmodified gold nanoparticles into poly(oligo(ethylene glycol)methacrylate) (POEGMA) brushes grown on glass. Our work reports the first synergistic combination of metallic nanoparticles acting as a colorimetric sensing module with a nonfouling polymer matrix acting both as a nonrigid scaffold and a screen to reduce interference from nontarget molecules. In addition, as the nanocomposite is formed on a transparent substrate, solid-phase detection can be performed in the same manner as in the solution-phase. We demonstrate the use of this unique platform for label-free lead detection based on the release of gold nanoparticles from the polymer brush upon exposure to lead ions. An ultralow limit-of-detection of 25 pM (S/N = 3) and a dynamic range of 100 pM to 100 nM (R2 = 0.987) are achieved. Furthermore, the detection is up to 1000-fold more selective to lead over other common heavy metal ions.
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UR - http://www.scopus.com/inward/citedby.url?scp=84876234314&partnerID=8YFLogxK
U2 - 10.1021/ac4001817
DO - 10.1021/ac4001817
M3 - Article
VL - 85
SP - 4094
EP - 4099
JO - Analytical Chemistry
JF - Analytical Chemistry
SN - 0003-2700
IS - 8
ER -