Solid-phase colorimetric sensor based on gold nanoparticle-loaded polymer brushes: Lead detection as a case study

Abdul Rahim Ferhan, Longhua Guo, Xiaodong Zhou, Peng Chen, Seungpyo Hong, Dong Hwan Kim

Research output: Contribution to journalArticle

66 Citations (Scopus)

Abstract

We introduce a novel solid-phase colorimetric sensor facilely fabricated by loading unmodified gold nanoparticles into poly(oligo(ethylene glycol)methacrylate) (POEGMA) brushes grown on glass. Our work reports the first synergistic combination of metallic nanoparticles acting as a colorimetric sensing module with a nonfouling polymer matrix acting both as a nonrigid scaffold and a screen to reduce interference from nontarget molecules. In addition, as the nanocomposite is formed on a transparent substrate, solid-phase detection can be performed in the same manner as in the solution-phase. We demonstrate the use of this unique platform for label-free lead detection based on the release of gold nanoparticles from the polymer brush upon exposure to lead ions. An ultralow limit-of-detection of 25 pM (S/N = 3) and a dynamic range of 100 pM to 100 nM (R2 = 0.987) are achieved. Furthermore, the detection is up to 1000-fold more selective to lead over other common heavy metal ions.

Original languageEnglish
Pages (from-to)4094-4099
Number of pages6
JournalAnalytical Chemistry
Volume85
Issue number8
DOIs
Publication statusPublished - 2013 Apr 16

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Brushes
Gold
Polymers
Nanoparticles
Sensors
Heavy Metals
Polymer matrix
Heavy ions
Scaffolds
Metal ions
Labels
Nanocomposites
Ions
Glass
Molecules
Substrates
Lead

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry

Cite this

Ferhan, Abdul Rahim ; Guo, Longhua ; Zhou, Xiaodong ; Chen, Peng ; Hong, Seungpyo ; Kim, Dong Hwan. / Solid-phase colorimetric sensor based on gold nanoparticle-loaded polymer brushes : Lead detection as a case study. In: Analytical Chemistry. 2013 ; Vol. 85, No. 8. pp. 4094-4099.
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Solid-phase colorimetric sensor based on gold nanoparticle-loaded polymer brushes : Lead detection as a case study. / Ferhan, Abdul Rahim; Guo, Longhua; Zhou, Xiaodong; Chen, Peng; Hong, Seungpyo; Kim, Dong Hwan.

In: Analytical Chemistry, Vol. 85, No. 8, 16.04.2013, p. 4094-4099.

Research output: Contribution to journalArticle

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