Solid-phase combinatorial synthesis and cytotoxicity of 3-aryl-2,4-quinazolindiones

Hea Young Park Choo; Mihyun Kim; Sang Kook Lee; Sang Woong Kim; In Kwon Chung

doi:10.1016/S0968-0896(01)00299-1

Solid-phase combinatorial synthesis and cytotoxicity of 3-aryl-2,4-quinazolindiones

Hea Young Park Choo, Mihyun Kim, Sang Kook Lee, Sang Woong Kim, In Kwon Chung

Research output: Contribution to journal › Article › peer-review

52 Citations (Scopus)

Abstract

A series of 3-aryl-2,4-quinazolinediones with various substitution on aromatic rings has been prepared by solid-phase synthesis. Several compounds showed cytotoxicity on human colon carcinoma (Col2) tested by SRB method.

Original language	English
Pages (from-to)	517-523
Number of pages	7
Journal	Bioorganic and Medicinal Chemistry
Volume	10
Issue number	3
DOIs	https://doi.org/10.1016/S0968-0896(01)00299-1
Publication status	Published - 2002

Bibliographical note

Funding Information:
This work was supported by a grant from Korea Research Foundation (300-1392).

All Science Journal Classification (ASJC) codes

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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title = "Solid-phase combinatorial synthesis and cytotoxicity of 3-aryl-2,4-quinazolindiones",

abstract = "A series of 3-aryl-2,4-quinazolinediones with various substitution on aromatic rings has been prepared by solid-phase synthesis. Several compounds showed cytotoxicity on human colon carcinoma (Col2) tested by SRB method.",

author = "{Park Choo}, {Hea Young} and Mihyun Kim and Lee, {Sang Kook} and {Woong Kim}, Sang and {Kwon Chung}, In",

note = "Funding Information: This work was supported by a grant from Korea Research Foundation (300-1392). ",

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doi = "10.1016/S0968-0896(01)00299-1",

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AU - Park Choo, Hea Young

AU - Kim, Mihyun

AU - Lee, Sang Kook

AU - Woong Kim, Sang

AU - Kwon Chung, In

N1 - Funding Information: This work was supported by a grant from Korea Research Foundation (300-1392).

PY - 2002

Y1 - 2002

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AB - A series of 3-aryl-2,4-quinazolinediones with various substitution on aromatic rings has been prepared by solid-phase synthesis. Several compounds showed cytotoxicity on human colon carcinoma (Col2) tested by SRB method.

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DO - 10.1016/S0968-0896(01)00299-1

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EP - 523

JO - Bioorganic and Medicinal Chemistry

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