Solid-phase combinatorial synthesis and cytotoxicity of 3-aryl-2,4-quinazolindiones

Hea Young Park Choo, Mihyun Kim, Sang Kook Lee, Sang Woong Kim, In Kwon Chung

Research output: Contribution to journal › Article

50 Citations (Scopus)

Abstract

A series of 3-aryl-2,4-quinazolinediones with various substitution on aromatic rings has been prepared by solid-phase synthesis. Several compounds showed cytotoxicity on human colon carcinoma (Col2) tested by SRB method.

Original languageEnglish
Pages (from-to)517-523
Number of pages7
JournalBioorganic and Medicinal Chemistry
Volume10
Issue number3
DOIs
Publication statusPublished - 2002 Feb 11

Fingerprint

Solid-Phase Synthesis Techniques
Cytotoxicity
Colon
Substitution reactions
Carcinoma
2,4(1H,3H)-quinazolinedione

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

Cite this

Park Choo, Hea Young ; Kim, Mihyun ; Lee, Sang Kook ; Woong Kim, Sang ; Chung, In Kwon. / Solid-phase combinatorial synthesis and cytotoxicity of 3-aryl-2,4-quinazolindiones. In: Bioorganic and Medicinal Chemistry. 2002 ; Vol. 10, No. 3. pp. 517-523.
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abstract = "A series of 3-aryl-2,4-quinazolinediones with various substitution on aromatic rings has been prepared by solid-phase synthesis. Several compounds showed cytotoxicity on human colon carcinoma (Col2) tested by SRB method.",
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Park Choo, HY, Kim, M, Lee, SK, Woong Kim, S & Chung, IK 2002, 'Solid-phase combinatorial synthesis and cytotoxicity of 3-aryl-2,4-quinazolindiones', Bioorganic and Medicinal Chemistry, vol. 10, no. 3, pp. 517-523. https://doi.org/10.1016/S0968-0896(01)00299-1

Solid-phase combinatorial synthesis and cytotoxicity of 3-aryl-2,4-quinazolindiones. / Park Choo, Hea Young; Kim, Mihyun; Lee, Sang Kook; Woong Kim, Sang; Chung, In Kwon.

In: Bioorganic and Medicinal Chemistry, Vol. 10, No. 3, 11.02.2002, p. 517-523.

Research output: Contribution to journal › Article

TY - JOUR

T1 - Solid-phase combinatorial synthesis and cytotoxicity of 3-aryl-2,4-quinazolindiones

AU - Park Choo, Hea Young

AU - Kim, Mihyun

AU - Lee, Sang Kook

AU - Woong Kim, Sang

AU - Chung, In Kwon

PY - 2002/2/11

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N2 - A series of 3-aryl-2,4-quinazolinediones with various substitution on aromatic rings has been prepared by solid-phase synthesis. Several compounds showed cytotoxicity on human colon carcinoma (Col2) tested by SRB method.

AB - A series of 3-aryl-2,4-quinazolinediones with various substitution on aromatic rings has been prepared by solid-phase synthesis. Several compounds showed cytotoxicity on human colon carcinoma (Col2) tested by SRB method.

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Park Choo HY, Kim M, Lee SK, Woong Kim S, Chung IK. Solid-phase combinatorial synthesis and cytotoxicity of 3-aryl-2,4-quinazolindiones. Bioorganic and Medicinal Chemistry. 2002 Feb 11;10(3):517-523. https://doi.org/10.1016/S0968-0896(01)00299-1

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