Solid pseudopapillary tumor of the pancreas suggesting malignant potential

ChangMoo Kang, Sik Kim Kyung, Sub Choi Jin, Hoguen Kim, Jung Lee Woo, Ro Kim Byong

Research output: Contribution to journalReview article

117 Citations (Scopus)

Abstract

Objectives: It has been suggested that the histopathologic features associated with malignant potential in solid pseudopapillary tumors (SPTs) of the pancreas include cellular polymorphism, mitotic activity, peripancreatic tissue invasion, neural invasion, lymphovascular invasion, and lymph node metastasis. This study aimed to delineate the features predicting SPTs with malignant potential, which can be easily assessed in the clinical setting, and long-term results of patients who underwent resection of SPT. Methods: A retrospective review and analysis were done of 33 patients who had SPTs that were surgically treated. Results: Eleven patients (33.3%) had SPTs suggesting malignant potential among surgically treated patients with SPTs. The local invasion to the peripancreatic tissue was the most frequent malignant pathological feature (7/11 patients, 63.7%). Using univariate analysis, tumor size greater than 5 cm was a significant clinical factor to predict SPTs with malignant potential (P = 0.022). The prognosis was excellent. No statistically significant survival difference was noted between groups of malignant potential and benign pathology (P = 0.1904). Conclusions: Malignant SPTs are low-grade tumors with good prognosis. Adequate surgical intervention is necessary. Especially, SPTs over 5 cm in diameter need to be treated carefully because of the chance of malignant pathology. Careful long-term follow-up is necessary in those patients in case of possible tumor recurrences.

Original languageEnglish
Pages (from-to)276-280
Number of pages5
JournalPancreas
Volume32
Issue number3
DOIs
Publication statusPublished - 2006 Apr 1

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Pancreas
Neoplasms
Pathology
Lymph Nodes
Neoplasm Metastasis
Recurrence
Survival

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Hepatology
  • Endocrinology

Cite this

Kang, ChangMoo ; Kyung, Sik Kim ; Jin, Sub Choi ; Kim, Hoguen ; Woo, Jung Lee ; Byong, Ro Kim. / Solid pseudopapillary tumor of the pancreas suggesting malignant potential. In: Pancreas. 2006 ; Vol. 32, No. 3. pp. 276-280.
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abstract = "Objectives: It has been suggested that the histopathologic features associated with malignant potential in solid pseudopapillary tumors (SPTs) of the pancreas include cellular polymorphism, mitotic activity, peripancreatic tissue invasion, neural invasion, lymphovascular invasion, and lymph node metastasis. This study aimed to delineate the features predicting SPTs with malignant potential, which can be easily assessed in the clinical setting, and long-term results of patients who underwent resection of SPT. Methods: A retrospective review and analysis were done of 33 patients who had SPTs that were surgically treated. Results: Eleven patients (33.3{\%}) had SPTs suggesting malignant potential among surgically treated patients with SPTs. The local invasion to the peripancreatic tissue was the most frequent malignant pathological feature (7/11 patients, 63.7{\%}). Using univariate analysis, tumor size greater than 5 cm was a significant clinical factor to predict SPTs with malignant potential (P = 0.022). The prognosis was excellent. No statistically significant survival difference was noted between groups of malignant potential and benign pathology (P = 0.1904). Conclusions: Malignant SPTs are low-grade tumors with good prognosis. Adequate surgical intervention is necessary. Especially, SPTs over 5 cm in diameter need to be treated carefully because of the chance of malignant pathology. Careful long-term follow-up is necessary in those patients in case of possible tumor recurrences.",
author = "ChangMoo Kang and Kyung, {Sik Kim} and Jin, {Sub Choi} and Hoguen Kim and Woo, {Jung Lee} and Byong, {Ro Kim}",
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Solid pseudopapillary tumor of the pancreas suggesting malignant potential. / Kang, ChangMoo; Kyung, Sik Kim; Jin, Sub Choi; Kim, Hoguen; Woo, Jung Lee; Byong, Ro Kim.

In: Pancreas, Vol. 32, No. 3, 01.04.2006, p. 276-280.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Solid pseudopapillary tumor of the pancreas suggesting malignant potential

AU - Kang, ChangMoo

AU - Kyung, Sik Kim

AU - Jin, Sub Choi

AU - Kim, Hoguen

AU - Woo, Jung Lee

AU - Byong, Ro Kim

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N2 - Objectives: It has been suggested that the histopathologic features associated with malignant potential in solid pseudopapillary tumors (SPTs) of the pancreas include cellular polymorphism, mitotic activity, peripancreatic tissue invasion, neural invasion, lymphovascular invasion, and lymph node metastasis. This study aimed to delineate the features predicting SPTs with malignant potential, which can be easily assessed in the clinical setting, and long-term results of patients who underwent resection of SPT. Methods: A retrospective review and analysis were done of 33 patients who had SPTs that were surgically treated. Results: Eleven patients (33.3%) had SPTs suggesting malignant potential among surgically treated patients with SPTs. The local invasion to the peripancreatic tissue was the most frequent malignant pathological feature (7/11 patients, 63.7%). Using univariate analysis, tumor size greater than 5 cm was a significant clinical factor to predict SPTs with malignant potential (P = 0.022). The prognosis was excellent. No statistically significant survival difference was noted between groups of malignant potential and benign pathology (P = 0.1904). Conclusions: Malignant SPTs are low-grade tumors with good prognosis. Adequate surgical intervention is necessary. Especially, SPTs over 5 cm in diameter need to be treated carefully because of the chance of malignant pathology. Careful long-term follow-up is necessary in those patients in case of possible tumor recurrences.

AB - Objectives: It has been suggested that the histopathologic features associated with malignant potential in solid pseudopapillary tumors (SPTs) of the pancreas include cellular polymorphism, mitotic activity, peripancreatic tissue invasion, neural invasion, lymphovascular invasion, and lymph node metastasis. This study aimed to delineate the features predicting SPTs with malignant potential, which can be easily assessed in the clinical setting, and long-term results of patients who underwent resection of SPT. Methods: A retrospective review and analysis were done of 33 patients who had SPTs that were surgically treated. Results: Eleven patients (33.3%) had SPTs suggesting malignant potential among surgically treated patients with SPTs. The local invasion to the peripancreatic tissue was the most frequent malignant pathological feature (7/11 patients, 63.7%). Using univariate analysis, tumor size greater than 5 cm was a significant clinical factor to predict SPTs with malignant potential (P = 0.022). The prognosis was excellent. No statistically significant survival difference was noted between groups of malignant potential and benign pathology (P = 0.1904). Conclusions: Malignant SPTs are low-grade tumors with good prognosis. Adequate surgical intervention is necessary. Especially, SPTs over 5 cm in diameter need to be treated carefully because of the chance of malignant pathology. Careful long-term follow-up is necessary in those patients in case of possible tumor recurrences.

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