Soluble fms-like tyrosine kinase-1 and the progression of carotid intima-media thickness: 24-month follow-up study

Sanghoon Shin, Sang Hak Lee, Sungha Park, Seok Min Kang, Namsik Chung, Won Heum Shim, Seung Yun Cho, Ichiro Manabe, Yangsoo Jang

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Background: The relationship between fms-like tyrosine kinase-1 (sFlt-1), a soluble receptor for vascular endothelial growth factor (VEGF), and vascular disease has not been established, so this study aimed to elucidate the association between sFlt-1 and the progression of carotid intima - media thickness (IMT) in hypertensive patients. Methods and Results: The 120 hypertensive patients under medical control were enrolled and 112 completed the study (age 59±9 years, 57 females). Plasma VEGF and sFlt-1 levels were measured at enrollment. At baseline and 24-month visit, carotid IMT was measured and the association between sFlt-1 and IMT progression was assessed by linear regression. At baseline, age (r=0.186) and low level of high-density lipoprotein-cholesterol (HDL-C <40 mg/dl, r=0.214) were significantly related to carotid IMT. Over the 24 months, carotid IMT increased from 0.670±0.089 mm to 0.696±0.095 mm. There was a positive correlation between sFlt-1 tertiles and IMT change (P=0.05 by ANOVA). Upon multivariate analysis, log-transformed sFlt-1 level (β=0.137, P=0.003) and low HDL-C (β=0.048, P=0.04) were identified as predictors of IMT progression, independent of other confounding variables. Conclusions: High sFlt-1 level is predictive of carotid IMT progression in hypertensive patients. Low HDL-C level was also associated with IMT change. These observations support a high sFlt-1 level being indicative of progression of atherosclerosis.

Original languageEnglish
Pages (from-to)2211-2215
Number of pages5
JournalCirculation Journal
Volume74
Issue number10
DOIs
Publication statusPublished - 2010 Oct 25

Fingerprint

Vascular Endothelial Growth Factor Receptor-1
Carotid Intima-Media Thickness
Vascular Endothelial Growth Factor Receptor
Confounding Factors (Epidemiology)
Vascular Diseases
HDL Cholesterol
Vascular Endothelial Growth Factor A
Linear Models
Atherosclerosis
Analysis of Variance
Multivariate Analysis

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Shin, Sanghoon ; Lee, Sang Hak ; Park, Sungha ; Kang, Seok Min ; Chung, Namsik ; Shim, Won Heum ; Cho, Seung Yun ; Manabe, Ichiro ; Jang, Yangsoo. / Soluble fms-like tyrosine kinase-1 and the progression of carotid intima-media thickness : 24-month follow-up study. In: Circulation Journal. 2010 ; Vol. 74, No. 10. pp. 2211-2215.
@article{158c47a447944ee984187269ba55ba28,
title = "Soluble fms-like tyrosine kinase-1 and the progression of carotid intima-media thickness: 24-month follow-up study",
abstract = "Background: The relationship between fms-like tyrosine kinase-1 (sFlt-1), a soluble receptor for vascular endothelial growth factor (VEGF), and vascular disease has not been established, so this study aimed to elucidate the association between sFlt-1 and the progression of carotid intima - media thickness (IMT) in hypertensive patients. Methods and Results: The 120 hypertensive patients under medical control were enrolled and 112 completed the study (age 59±9 years, 57 females). Plasma VEGF and sFlt-1 levels were measured at enrollment. At baseline and 24-month visit, carotid IMT was measured and the association between sFlt-1 and IMT progression was assessed by linear regression. At baseline, age (r=0.186) and low level of high-density lipoprotein-cholesterol (HDL-C <40 mg/dl, r=0.214) were significantly related to carotid IMT. Over the 24 months, carotid IMT increased from 0.670±0.089 mm to 0.696±0.095 mm. There was a positive correlation between sFlt-1 tertiles and IMT change (P=0.05 by ANOVA). Upon multivariate analysis, log-transformed sFlt-1 level (β=0.137, P=0.003) and low HDL-C (β=0.048, P=0.04) were identified as predictors of IMT progression, independent of other confounding variables. Conclusions: High sFlt-1 level is predictive of carotid IMT progression in hypertensive patients. Low HDL-C level was also associated with IMT change. These observations support a high sFlt-1 level being indicative of progression of atherosclerosis.",
author = "Sanghoon Shin and Lee, {Sang Hak} and Sungha Park and Kang, {Seok Min} and Namsik Chung and Shim, {Won Heum} and Cho, {Seung Yun} and Ichiro Manabe and Yangsoo Jang",
year = "2010",
month = "10",
day = "25",
doi = "10.1253/circj.CJ-10-0432",
language = "English",
volume = "74",
pages = "2211--2215",
journal = "Circulation Journal",
issn = "1346-9843",
publisher = "Japanese Circulation Society",
number = "10",

}

Soluble fms-like tyrosine kinase-1 and the progression of carotid intima-media thickness : 24-month follow-up study. / Shin, Sanghoon; Lee, Sang Hak; Park, Sungha; Kang, Seok Min; Chung, Namsik; Shim, Won Heum; Cho, Seung Yun; Manabe, Ichiro; Jang, Yangsoo.

In: Circulation Journal, Vol. 74, No. 10, 25.10.2010, p. 2211-2215.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Soluble fms-like tyrosine kinase-1 and the progression of carotid intima-media thickness

T2 - 24-month follow-up study

AU - Shin, Sanghoon

AU - Lee, Sang Hak

AU - Park, Sungha

AU - Kang, Seok Min

AU - Chung, Namsik

AU - Shim, Won Heum

AU - Cho, Seung Yun

AU - Manabe, Ichiro

AU - Jang, Yangsoo

PY - 2010/10/25

Y1 - 2010/10/25

N2 - Background: The relationship between fms-like tyrosine kinase-1 (sFlt-1), a soluble receptor for vascular endothelial growth factor (VEGF), and vascular disease has not been established, so this study aimed to elucidate the association between sFlt-1 and the progression of carotid intima - media thickness (IMT) in hypertensive patients. Methods and Results: The 120 hypertensive patients under medical control were enrolled and 112 completed the study (age 59±9 years, 57 females). Plasma VEGF and sFlt-1 levels were measured at enrollment. At baseline and 24-month visit, carotid IMT was measured and the association between sFlt-1 and IMT progression was assessed by linear regression. At baseline, age (r=0.186) and low level of high-density lipoprotein-cholesterol (HDL-C <40 mg/dl, r=0.214) were significantly related to carotid IMT. Over the 24 months, carotid IMT increased from 0.670±0.089 mm to 0.696±0.095 mm. There was a positive correlation between sFlt-1 tertiles and IMT change (P=0.05 by ANOVA). Upon multivariate analysis, log-transformed sFlt-1 level (β=0.137, P=0.003) and low HDL-C (β=0.048, P=0.04) were identified as predictors of IMT progression, independent of other confounding variables. Conclusions: High sFlt-1 level is predictive of carotid IMT progression in hypertensive patients. Low HDL-C level was also associated with IMT change. These observations support a high sFlt-1 level being indicative of progression of atherosclerosis.

AB - Background: The relationship between fms-like tyrosine kinase-1 (sFlt-1), a soluble receptor for vascular endothelial growth factor (VEGF), and vascular disease has not been established, so this study aimed to elucidate the association between sFlt-1 and the progression of carotid intima - media thickness (IMT) in hypertensive patients. Methods and Results: The 120 hypertensive patients under medical control were enrolled and 112 completed the study (age 59±9 years, 57 females). Plasma VEGF and sFlt-1 levels were measured at enrollment. At baseline and 24-month visit, carotid IMT was measured and the association between sFlt-1 and IMT progression was assessed by linear regression. At baseline, age (r=0.186) and low level of high-density lipoprotein-cholesterol (HDL-C <40 mg/dl, r=0.214) were significantly related to carotid IMT. Over the 24 months, carotid IMT increased from 0.670±0.089 mm to 0.696±0.095 mm. There was a positive correlation between sFlt-1 tertiles and IMT change (P=0.05 by ANOVA). Upon multivariate analysis, log-transformed sFlt-1 level (β=0.137, P=0.003) and low HDL-C (β=0.048, P=0.04) were identified as predictors of IMT progression, independent of other confounding variables. Conclusions: High sFlt-1 level is predictive of carotid IMT progression in hypertensive patients. Low HDL-C level was also associated with IMT change. These observations support a high sFlt-1 level being indicative of progression of atherosclerosis.

UR - http://www.scopus.com/inward/record.url?scp=77958044798&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77958044798&partnerID=8YFLogxK

U2 - 10.1253/circj.CJ-10-0432

DO - 10.1253/circj.CJ-10-0432

M3 - Article

C2 - 20689217

AN - SCOPUS:77958044798

VL - 74

SP - 2211

EP - 2215

JO - Circulation Journal

JF - Circulation Journal

SN - 1346-9843

IS - 10

ER -