Soluble Urokinase Receptors in Focal Segmental Glomerulosclerosis: A Review on the Scientific Point of View

Andreas Kronbichler, Moin A. Saleem, Björn Meijers, Jae Il Shin

Research output: Contribution to journalReview article

25 Citations (Scopus)

Abstract

Focal segmental glomerulosclerosis (FSGS) is one of the primary glomerular disorders in both children and adults which can progress to end-stage renal failure. Although there are genetic and secondary causes, circulating factors have also been regarded as an important factor in the pathogenesis of FSGS, because about 40% of the patients with FSGS have recurrence after renal transplantation. Soluble urokinase-type plasminogen activator receptor (suPAR) is a soluble form of uPAR, which is a membrane-bound protein linked to GPI in various immunologically active cells, including podocytes. It has recently been suggested as a potential circulating factor in FSGS by in vitro podocyte experiments, in vivo mice models, and human studies. However, there have also been controversies on this issue, because subsequent studies showed conflicting results. suPAR levels were also increased in patients with other glomerular diseases and were inversely correlated with estimated glomerular filtration rate. Nevertheless, there has been no balanced review on this issue. In this review, we compare the conflicting data on the involvement of suPAR in the pathogenesis of FSGS and shed light on interpretation by taking into account many points and the potential variables and confounders influencing serum suPAR levels.

Original languageEnglish
Article number2068691
JournalJournal of immunology research
Volume2016
DOIs
Publication statusPublished - 2016 Jan 1

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Focal Segmental Glomerulosclerosis
Urokinase Plasminogen Activator Receptors
Urokinase-Type Plasminogen Activator
Podocytes
Glomerular Filtration Rate
Kidney Transplantation
Chronic Kidney Failure
Membrane Proteins
Recurrence
Serum

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

Cite this

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Soluble Urokinase Receptors in Focal Segmental Glomerulosclerosis : A Review on the Scientific Point of View. / Kronbichler, Andreas; Saleem, Moin A.; Meijers, Björn; Shin, Jae Il.

In: Journal of immunology research, Vol. 2016, 2068691, 01.01.2016.

Research output: Contribution to journalReview article

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