TY - JOUR
T1 - "Solvent-less" mechanochemical approach to the synthesis of pyrimidine derivatives
AU - Raj, Tilak
AU - Sharma, Hemant
AU - Mayank,
AU - Singh, Ajnesh
AU - Aree, Thammarat
AU - Kaur, Navneet
AU - Singh, Narinder
AU - Jang, Doo Ok
N1 - Publisher Copyright:
© 2017 American Chemical Society.
Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 2017/2/6
Y1 - 2017/2/6
N2 - Modified ZnO NPs were synthesized through a sol-gel route with an aromatic capping agent to provide a highly efficient catalyst, NS-5, for the one-pot multicomponent synthesis of various pyrimidine derivatives using a solvent-free ball milling technique. Greenness of the present method was evaluated by calculating an Ecoscale score and E-factor. Characteristics of the method include use of a recyclable catalyst, scale-up to a multigram scale, and ease of product isolation.
AB - Modified ZnO NPs were synthesized through a sol-gel route with an aromatic capping agent to provide a highly efficient catalyst, NS-5, for the one-pot multicomponent synthesis of various pyrimidine derivatives using a solvent-free ball milling technique. Greenness of the present method was evaluated by calculating an Ecoscale score and E-factor. Characteristics of the method include use of a recyclable catalyst, scale-up to a multigram scale, and ease of product isolation.
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U2 - 10.1021/acssuschemeng.6b02030
DO - 10.1021/acssuschemeng.6b02030
M3 - Article
AN - SCOPUS:85011883202
VL - 5
SP - 1468
EP - 1475
JO - ACS Sustainable Chemistry and Engineering
JF - ACS Sustainable Chemistry and Engineering
SN - 2168-0485
IS - 2
ER -