"Solvent-less" mechanochemical approach to the synthesis of pyrimidine derivatives

Tilak Raj; Hemant Sharma; Mayank; Ajnesh Singh; Thammarat Aree; Navneet Kaur; Narinder Singh; Doo Ok Jang

doi:10.1021/acssuschemeng.6b02030

"Solvent-less" mechanochemical approach to the synthesis of pyrimidine derivatives

Tilak Raj, Hemant Sharma, Mayank, Ajnesh Singh, Thammarat Aree, Navneet Kaur, Narinder Singh, Doo Ok Jang

Chemistry and Medical Chemistry

Research output: Contribution to journal › Article › peer-review

26 Citations (Scopus)

Abstract

Modified ZnO NPs were synthesized through a sol-gel route with an aromatic capping agent to provide a highly efficient catalyst, NS-5, for the one-pot multicomponent synthesis of various pyrimidine derivatives using a solvent-free ball milling technique. Greenness of the present method was evaluated by calculating an Ecoscale score and E-factor. Characteristics of the method include use of a recyclable catalyst, scale-up to a multigram scale, and ease of product isolation.

Original language	English
Pages (from-to)	1468-1475
Number of pages	8
Journal	ACS Sustainable Chemistry and Engineering
Volume	5
Issue number	2
DOIs	https://doi.org/10.1021/acssuschemeng.6b02030
Publication status	Published - 2017 Feb 6

All Science Journal Classification (ASJC) codes

Chemistry(all)
Environmental Chemistry
Chemical Engineering(all)
Renewable Energy, Sustainability and the Environment

Access to Document

10.1021/acssuschemeng.6b02030

Fingerprint Dive into the research topics of '"Solvent-less" mechanochemical approach to the synthesis of pyrimidine derivatives'. Together they form a unique fingerprint.

Cite this

@article{951824bcc9104ef39e53e3e7eb0c430e,

title = "{"}Solvent-less{"} mechanochemical approach to the synthesis of pyrimidine derivatives",

abstract = "Modified ZnO NPs were synthesized through a sol-gel route with an aromatic capping agent to provide a highly efficient catalyst, NS-5, for the one-pot multicomponent synthesis of various pyrimidine derivatives using a solvent-free ball milling technique. Greenness of the present method was evaluated by calculating an Ecoscale score and E-factor. Characteristics of the method include use of a recyclable catalyst, scale-up to a multigram scale, and ease of product isolation.",

author = "Tilak Raj and Hemant Sharma and Mayank and Ajnesh Singh and Thammarat Aree and Navneet Kaur and Narinder Singh and Jang, {Doo Ok}",

year = "2017",

month = feb,

day = "6",

doi = "10.1021/acssuschemeng.6b02030",

language = "English",

volume = "5",

pages = "1468--1475",

journal = "ACS Sustainable Chemistry and Engineering",

issn = "2168-0485",

publisher = "American Chemical Society",

number = "2",

}

TY - JOUR

T1 - "Solvent-less" mechanochemical approach to the synthesis of pyrimidine derivatives

AU - Raj, Tilak

AU - Sharma, Hemant

AU - Mayank,

AU - Singh, Ajnesh

AU - Aree, Thammarat

AU - Kaur, Navneet

AU - Singh, Narinder

AU - Jang, Doo Ok

PY - 2017/2/6

Y1 - 2017/2/6

N2 - Modified ZnO NPs were synthesized through a sol-gel route with an aromatic capping agent to provide a highly efficient catalyst, NS-5, for the one-pot multicomponent synthesis of various pyrimidine derivatives using a solvent-free ball milling technique. Greenness of the present method was evaluated by calculating an Ecoscale score and E-factor. Characteristics of the method include use of a recyclable catalyst, scale-up to a multigram scale, and ease of product isolation.

AB - Modified ZnO NPs were synthesized through a sol-gel route with an aromatic capping agent to provide a highly efficient catalyst, NS-5, for the one-pot multicomponent synthesis of various pyrimidine derivatives using a solvent-free ball milling technique. Greenness of the present method was evaluated by calculating an Ecoscale score and E-factor. Characteristics of the method include use of a recyclable catalyst, scale-up to a multigram scale, and ease of product isolation.

UR - http://www.scopus.com/inward/record.url?scp=85011883202&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85011883202&partnerID=8YFLogxK

U2 - 10.1021/acssuschemeng.6b02030

DO - 10.1021/acssuschemeng.6b02030

M3 - Article

AN - SCOPUS:85011883202

VL - 5

SP - 1468

EP - 1475

JO - ACS Sustainable Chemistry and Engineering

JF - ACS Sustainable Chemistry and Engineering

SN - 2168-0485

IS - 2

ER -