"Solvent-less" mechanochemical approach to the synthesis of pyrimidine derivatives

Tilak Raj; Hemant Sharma; Mayank; Ajnesh Singh; Thammarat Aree; Navneet Kaur; Narinder Singh; Doo Ok Jang

doi:10.1021/acssuschemeng.6b02030

"Solvent-less" mechanochemical approach to the synthesis of pyrimidine derivatives

Tilak Raj, Hemant Sharma, Mayank, Ajnesh Singh, Thammarat Aree, Navneet Kaur, Narinder Singh, Doo Ok Jang

Chemistry and Medical Chemistry

Research output: Contribution to journal › Article › peer-review

29 Citations (Scopus)

Abstract

Modified ZnO NPs were synthesized through a sol-gel route with an aromatic capping agent to provide a highly efficient catalyst, NS-5, for the one-pot multicomponent synthesis of various pyrimidine derivatives using a solvent-free ball milling technique. Greenness of the present method was evaluated by calculating an Ecoscale score and E-factor. Characteristics of the method include use of a recyclable catalyst, scale-up to a multigram scale, and ease of product isolation.

Original language	English
Pages (from-to)	1468-1475
Number of pages	8
Journal	ACS Sustainable Chemistry and Engineering
Volume	5
Issue number	2
DOIs	https://doi.org/10.1021/acssuschemeng.6b02030
Publication status	Published - 2017 Feb 6

Bibliographical note

Publisher Copyright:
© 2017 American Chemical Society.

All Science Journal Classification (ASJC) codes

Chemistry(all)
Environmental Chemistry
Chemical Engineering(all)
Renewable Energy, Sustainability and the Environment

UN SDGs

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10.1021/acssuschemeng.6b02030

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AU - Sharma, Hemant

AU - Mayank,

AU - Singh, Ajnesh

AU - Aree, Thammarat

AU - Kaur, Navneet

AU - Singh, Narinder

AU - Jang, Doo Ok

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"Solvent-less" mechanochemical approach to the synthesis of pyrimidine derivatives

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

UN SDGs

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