"Solvent-less" mechanochemical approach to the synthesis of pyrimidine derivatives

Tilak Raj, Hemant Sharma, Mayank, Ajnesh Singh, Thammarat Aree, Navneet Kaur, Narinder Singh, Doook Jang

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Modified ZnO NPs were synthesized through a sol-gel route with an aromatic capping agent to provide a highly efficient catalyst, NS-5, for the one-pot multicomponent synthesis of various pyrimidine derivatives using a solvent-free ball milling technique. Greenness of the present method was evaluated by calculating an Ecoscale score and E-factor. Characteristics of the method include use of a recyclable catalyst, scale-up to a multigram scale, and ease of product isolation.

Original languageEnglish
Pages (from-to)1468-1475
Number of pages8
JournalACS Sustainable Chemistry and Engineering
Volume5
Issue number2
DOIs
Publication statusPublished - 2017 Feb 6

Fingerprint

catalyst
Derivatives
Catalysts
capping
Ball milling
Sol-gels
gel
pyrimidine
method
8-dehydroxythienamycin
product

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Environmental Chemistry
  • Chemical Engineering(all)
  • Renewable Energy, Sustainability and the Environment

Cite this

Raj, Tilak ; Sharma, Hemant ; Mayank ; Singh, Ajnesh ; Aree, Thammarat ; Kaur, Navneet ; Singh, Narinder ; Jang, Doook. / "Solvent-less" mechanochemical approach to the synthesis of pyrimidine derivatives. In: ACS Sustainable Chemistry and Engineering. 2017 ; Vol. 5, No. 2. pp. 1468-1475.
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"Solvent-less" mechanochemical approach to the synthesis of pyrimidine derivatives. / Raj, Tilak; Sharma, Hemant; Mayank; Singh, Ajnesh; Aree, Thammarat; Kaur, Navneet; Singh, Narinder; Jang, Doook.

In: ACS Sustainable Chemistry and Engineering, Vol. 5, No. 2, 06.02.2017, p. 1468-1475.

Research output: Contribution to journalArticle

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