"Solvent-less" mechanochemical approach to the synthesis of pyrimidine derivatives

Tilak Raj; Hemant Sharma; Mayank; Ajnesh Singh; Thammarat Aree; Navneet Kaur; Narinder Singh; Doo Ok Jang

doi:10.1021/acssuschemeng.6b02030

"Solvent-less" mechanochemical approach to the synthesis of pyrimidine derivatives

Tilak Raj, Hemant Sharma, Mayank, Ajnesh Singh, Thammarat Aree, Navneet Kaur, Narinder Singh, Doo Ok Jang

Chemistry and Medical Chemistry

Research output: Contribution to journal › Article

25 Citations (Scopus)

Abstract

Modified ZnO NPs were synthesized through a sol-gel route with an aromatic capping agent to provide a highly efficient catalyst, NS-5, for the one-pot multicomponent synthesis of various pyrimidine derivatives using a solvent-free ball milling technique. Greenness of the present method was evaluated by calculating an Ecoscale score and E-factor. Characteristics of the method include use of a recyclable catalyst, scale-up to a multigram scale, and ease of product isolation.

Original language	English
Pages (from-to)	1468-1475
Number of pages	8
Journal	ACS Sustainable Chemistry and Engineering
Volume	5
Issue number	2
DOIs	https://doi.org/10.1021/acssuschemeng.6b02030
Publication status	Published - 2017 Feb 6

All Science Journal Classification (ASJC) codes

Chemistry(all)
Environmental Chemistry
Chemical Engineering(all)
Renewable Energy, Sustainability and the Environment

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10.1021/acssuschemeng.6b02030

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Raj, T., Sharma, H., Mayank, Singh, A., Aree, T., Kaur, N., Singh, N., & Jang, D. O. (2017). "Solvent-less" mechanochemical approach to the synthesis of pyrimidine derivatives. ACS Sustainable Chemistry and Engineering, 5(2), 1468-1475. https://doi.org/10.1021/acssuschemeng.6b02030

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AU - Singh, Narinder

AU - Jang, Doo Ok

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