"Solvent-less" mechanochemical approach to the synthesis of pyrimidine derivatives

Tilak Raj; Hemant Sharma; Mayank; Ajnesh Singh; Thammarat Aree; Navneet Kaur; Narinder Singh; Doo Ok Jang

doi:10.1021/acssuschemeng.6b02030

"Solvent-less" mechanochemical approach to the synthesis of pyrimidine derivatives

Tilak Raj, Hemant Sharma, Mayank, Ajnesh Singh, Thammarat Aree, Navneet Kaur, Narinder Singh, Doo Ok Jang

Chemistry and Medical Chemistry

Research output: Contribution to journal › Article › peer-review

43 Citations (Scopus)

Abstract

Modified ZnO NPs were synthesized through a sol-gel route with an aromatic capping agent to provide a highly efficient catalyst, NS-5, for the one-pot multicomponent synthesis of various pyrimidine derivatives using a solvent-free ball milling technique. Greenness of the present method was evaluated by calculating an Ecoscale score and E-factor. Characteristics of the method include use of a recyclable catalyst, scale-up to a multigram scale, and ease of product isolation.

Original language	English
Pages (from-to)	1468-1475
Number of pages	8
Journal	ACS Sustainable Chemistry and Engineering
Volume	5
Issue number	2
DOIs	https://doi.org/10.1021/acssuschemeng.6b02030
Publication status	Published - 2017 Feb 6

Bibliographical note

Publisher Copyright:
© 2017 American Chemical Society.

All Science Journal Classification (ASJC) codes

Chemistry(all)
Environmental Chemistry
Chemical Engineering(all)
Renewable Energy, Sustainability and the Environment

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1021/acssuschemeng.6b02030

Cite this

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abstract = "Modified ZnO NPs were synthesized through a sol-gel route with an aromatic capping agent to provide a highly efficient catalyst, NS-5, for the one-pot multicomponent synthesis of various pyrimidine derivatives using a solvent-free ball milling technique. Greenness of the present method was evaluated by calculating an Ecoscale score and E-factor. Characteristics of the method include use of a recyclable catalyst, scale-up to a multigram scale, and ease of product isolation.",

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AU - Sharma, Hemant

AU - Mayank,

AU - Singh, Ajnesh

AU - Aree, Thammarat

AU - Kaur, Navneet

AU - Singh, Narinder

AU - Jang, Doo Ok

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AB - Modified ZnO NPs were synthesized through a sol-gel route with an aromatic capping agent to provide a highly efficient catalyst, NS-5, for the one-pot multicomponent synthesis of various pyrimidine derivatives using a solvent-free ball milling technique. Greenness of the present method was evaluated by calculating an Ecoscale score and E-factor. Characteristics of the method include use of a recyclable catalyst, scale-up to a multigram scale, and ease of product isolation.

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"Solvent-less" mechanochemical approach to the synthesis of pyrimidine derivatives

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

UN SDGs

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