Somatic gonad sheath cells and Eph receptor signaling promote germ-cell death in C. elegans

X. Li, R. W. Johnson, D. Park, I. Chin-Sang, H. M. Chamberlin

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Programmed cell death eliminates unwanted cells during normal development and physiological homeostasis. While cell interactions can influence apoptosis as they do other types of cell fate, outside of the adaptive immune system little is known about the intercellular cues that actively promote cell death in healthy cells. We used the Caenorhabditis elegans germline as a model to investigate the extrinsic regulators of physiological apoptosis. Using genetic and cell biological methods, we show that somatic gonad sheath cells, which also act as phagocytes of dying germ cells, promote death in the C. elegans germline through VAB-1/Eph receptor signaling. We report that the germline apoptosis function of VAB-1 impacts specific cell death pathways, and may act in parallel to extracellular signal-regulated kinase MAPK signaling. This work defines a non-autonomous, pro-apoptotic signaling for efficient physiological cell death, and highlights the dynamic nature of intercellular communication between dying cells and the phagocytes that remove them.

Original languageEnglish
Pages (from-to)1080-1089
Number of pages10
JournalCell Death and Differentiation
Volume19
Issue number6
DOIs
Publication statusPublished - 2012 Jun 1

Fingerprint

EphA1 Receptor
Gonads
Germ Cells
Cell Death
Caenorhabditis elegans
Phagocytes
Apoptosis
Extracellular Signal-Regulated MAP Kinases
Cell Communication
Cues
Immune System
Homeostasis

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Cell Biology

Cite this

Li, X. ; Johnson, R. W. ; Park, D. ; Chin-Sang, I. ; Chamberlin, H. M. / Somatic gonad sheath cells and Eph receptor signaling promote germ-cell death in C. elegans. In: Cell Death and Differentiation. 2012 ; Vol. 19, No. 6. pp. 1080-1089.
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Somatic gonad sheath cells and Eph receptor signaling promote germ-cell death in C. elegans. / Li, X.; Johnson, R. W.; Park, D.; Chin-Sang, I.; Chamberlin, H. M.

In: Cell Death and Differentiation, Vol. 19, No. 6, 01.06.2012, p. 1080-1089.

Research output: Contribution to journalArticle

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