Sonographic differentiation of thyroid nodules with eggshell calcifications

Byungmoon Kim, minjung Kim, Eunkyung Kim, jinyoung kwak, Won Hong Soon, Ju Son Eun, Hwang Kim Ki

Research output: Contribution to journalArticle

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Abstract

Objective. The purpose of this study was to assess the role of known suspicious sonographic findings and to find other additional sonographic findings to differentiate benign and malignant thyroid nodules with "eggshell" calcifications. Methods. Our Institutional Review Board approved this retrospective study, and informed consent was not required. We reviewed sonographic findings of thyroid nodules in 795 patients who underwent thyroid surgery in our institution between August 2006 and February 2007. Ninety-three thyroid nodules with eggshell calcifications in 92 patients were included in this study. Each lesion was evaluated for known suspicious sonographic criteria, including marked hypoechogenicity, irregular or microlobulated margins, and a taller-than-wide shape, as well as 2 additional sonographic findings: a hypoechoic halo and disruption of eggshell calcifications (halo and disrupted calcification rim). The sensitivity and specificity based on the sonographic criteria were calculated and compared among the 2 types of criteria. Results. Among the 93 thyroid nodules, 59 were malignant and 34 were benign. The halo and disrupted calcification rim showed higher sensitivity (62.7% and 76.3%, respectively) than any of the known suspicious sonographic criteria (40.7%, 35.6%, and 55.9%). The combination of both the halo and the disrupted calcification rim showed significantly higher sensitivity (93.2%) than the combination of the known suspicious sonographic criteria (78%; P < .05), although both had the same specificity (64.7%). Conclusions. In thyroid nodules with eggshell calcifications but no other calcifications, the findings of a peripheral halo and disruption of the eggshell calcifications may be more useful sonographic predictors of malignancy than hypo echogenicity, microlobulated margins, and a taller-than-wide shape.

Original languageEnglish
Pages (from-to)1425-1430
Number of pages6
JournalJournal of Ultrasound in Medicine
Volume27
Issue number10
Publication statusPublished - 2008 Oct 1

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Egg Shell
Thyroid Nodule
Research Ethics Committees
Informed Consent
Thyroid Gland
Retrospective Studies
Sensitivity and Specificity
Neoplasms

All Science Journal Classification (ASJC) codes

  • Radiological and Ultrasound Technology
  • Radiology Nuclear Medicine and imaging

Cite this

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title = "Sonographic differentiation of thyroid nodules with eggshell calcifications",
abstract = "Objective. The purpose of this study was to assess the role of known suspicious sonographic findings and to find other additional sonographic findings to differentiate benign and malignant thyroid nodules with {"}eggshell{"} calcifications. Methods. Our Institutional Review Board approved this retrospective study, and informed consent was not required. We reviewed sonographic findings of thyroid nodules in 795 patients who underwent thyroid surgery in our institution between August 2006 and February 2007. Ninety-three thyroid nodules with eggshell calcifications in 92 patients were included in this study. Each lesion was evaluated for known suspicious sonographic criteria, including marked hypoechogenicity, irregular or microlobulated margins, and a taller-than-wide shape, as well as 2 additional sonographic findings: a hypoechoic halo and disruption of eggshell calcifications (halo and disrupted calcification rim). The sensitivity and specificity based on the sonographic criteria were calculated and compared among the 2 types of criteria. Results. Among the 93 thyroid nodules, 59 were malignant and 34 were benign. The halo and disrupted calcification rim showed higher sensitivity (62.7{\%} and 76.3{\%}, respectively) than any of the known suspicious sonographic criteria (40.7{\%}, 35.6{\%}, and 55.9{\%}). The combination of both the halo and the disrupted calcification rim showed significantly higher sensitivity (93.2{\%}) than the combination of the known suspicious sonographic criteria (78{\%}; P < .05), although both had the same specificity (64.7{\%}). Conclusions. In thyroid nodules with eggshell calcifications but no other calcifications, the findings of a peripheral halo and disruption of the eggshell calcifications may be more useful sonographic predictors of malignancy than hypo echogenicity, microlobulated margins, and a taller-than-wide shape.",
author = "Byungmoon Kim and minjung Kim and Eunkyung Kim and jinyoung kwak and Soon, {Won Hong} and Eun, {Ju Son} and Ki, {Hwang Kim}",
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Sonographic differentiation of thyroid nodules with eggshell calcifications. / Kim, Byungmoon; Kim, minjung; Kim, Eunkyung; kwak, jinyoung; Soon, Won Hong; Eun, Ju Son; Ki, Hwang Kim.

In: Journal of Ultrasound in Medicine, Vol. 27, No. 10, 01.10.2008, p. 1425-1430.

Research output: Contribution to journalArticle

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T1 - Sonographic differentiation of thyroid nodules with eggshell calcifications

AU - Kim, Byungmoon

AU - Kim, minjung

AU - Kim, Eunkyung

AU - kwak, jinyoung

AU - Soon, Won Hong

AU - Eun, Ju Son

AU - Ki, Hwang Kim

PY - 2008/10/1

Y1 - 2008/10/1

N2 - Objective. The purpose of this study was to assess the role of known suspicious sonographic findings and to find other additional sonographic findings to differentiate benign and malignant thyroid nodules with "eggshell" calcifications. Methods. Our Institutional Review Board approved this retrospective study, and informed consent was not required. We reviewed sonographic findings of thyroid nodules in 795 patients who underwent thyroid surgery in our institution between August 2006 and February 2007. Ninety-three thyroid nodules with eggshell calcifications in 92 patients were included in this study. Each lesion was evaluated for known suspicious sonographic criteria, including marked hypoechogenicity, irregular or microlobulated margins, and a taller-than-wide shape, as well as 2 additional sonographic findings: a hypoechoic halo and disruption of eggshell calcifications (halo and disrupted calcification rim). The sensitivity and specificity based on the sonographic criteria were calculated and compared among the 2 types of criteria. Results. Among the 93 thyroid nodules, 59 were malignant and 34 were benign. The halo and disrupted calcification rim showed higher sensitivity (62.7% and 76.3%, respectively) than any of the known suspicious sonographic criteria (40.7%, 35.6%, and 55.9%). The combination of both the halo and the disrupted calcification rim showed significantly higher sensitivity (93.2%) than the combination of the known suspicious sonographic criteria (78%; P < .05), although both had the same specificity (64.7%). Conclusions. In thyroid nodules with eggshell calcifications but no other calcifications, the findings of a peripheral halo and disruption of the eggshell calcifications may be more useful sonographic predictors of malignancy than hypo echogenicity, microlobulated margins, and a taller-than-wide shape.

AB - Objective. The purpose of this study was to assess the role of known suspicious sonographic findings and to find other additional sonographic findings to differentiate benign and malignant thyroid nodules with "eggshell" calcifications. Methods. Our Institutional Review Board approved this retrospective study, and informed consent was not required. We reviewed sonographic findings of thyroid nodules in 795 patients who underwent thyroid surgery in our institution between August 2006 and February 2007. Ninety-three thyroid nodules with eggshell calcifications in 92 patients were included in this study. Each lesion was evaluated for known suspicious sonographic criteria, including marked hypoechogenicity, irregular or microlobulated margins, and a taller-than-wide shape, as well as 2 additional sonographic findings: a hypoechoic halo and disruption of eggshell calcifications (halo and disrupted calcification rim). The sensitivity and specificity based on the sonographic criteria were calculated and compared among the 2 types of criteria. Results. Among the 93 thyroid nodules, 59 were malignant and 34 were benign. The halo and disrupted calcification rim showed higher sensitivity (62.7% and 76.3%, respectively) than any of the known suspicious sonographic criteria (40.7%, 35.6%, and 55.9%). The combination of both the halo and the disrupted calcification rim showed significantly higher sensitivity (93.2%) than the combination of the known suspicious sonographic criteria (78%; P < .05), although both had the same specificity (64.7%). Conclusions. In thyroid nodules with eggshell calcifications but no other calcifications, the findings of a peripheral halo and disruption of the eggshell calcifications may be more useful sonographic predictors of malignancy than hypo echogenicity, microlobulated margins, and a taller-than-wide shape.

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