Sonophoresis Using Ultrasound Contrast Agents for Transdermal Drug Delivery: An In Vivo Experimental Study

Donghee Park, Heungil Ryu, Hansung Kim, Young sun Kim, Kyu Sil Choi, Hyunjin Park, Jongbum Seo

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Sonophoresis temporally increases skin permeability such that various medications can be delivered noninvasively. Previous sonophoresis studies have suggested that cavitation plays an important role in enhancing transdermal drug delivery (TDD). In this study, the feasibility of controlled cavitation using ultrasound contrast agents (UCAs) at high frequency was explored through in vivo experiments in a rat model. Two commercially available UCAs, SonoVue® and Definity®, were used at 2.47 MHz and 1.12 MHz, respectively. Fluorescein isothiocyanate (FITC)-dextran with 0.1% UCA was used as the drug to be delivered through the skin. Ultrasound with a 10 ms pulse and a 1% duty cycle at 1 MPa acoustic pressure for 30 min was applied in all sonication sessions. The efficacy of sonophoresis with UCAs was quantitatively analyzed using an optical imaging system that was used to count photons emitted from fluorescein. The results showed that the proposed sonophoresis method significantly improved drug penetration compared with the traditional sonophoresis method with 4 kD, 20 kD and 150 kD FITC-dextrans at 1.12 MHz, and with 4 kD and 20 kD FITC-dextrans at 2.47 MHz. Sonophoresis for TDD was performed more effectively with the aid of UCAs. Sonophoresis with UCAs has excellent potential for broad applications in drug delivery for diseases requiring the chronic administration of medications such as diabetes.

Original languageEnglish
Pages (from-to)642-650
Number of pages9
JournalUltrasound in Medicine and Biology
Volume38
Issue number4
DOIs
Publication statusPublished - 2012 Apr 1

Fingerprint

Contrast Media
delivery
drugs
dextrans
Pharmaceutical Preparations
cavitation flow
Optical Devices
Skin
Sonication
Optical Imaging
Fluorescein
Photons
Acoustics
rats
Permeability
permeability
Chronic Disease
penetration
Pressure
cycles

All Science Journal Classification (ASJC) codes

  • Radiological and Ultrasound Technology
  • Biophysics
  • Acoustics and Ultrasonics

Cite this

Park, Donghee ; Ryu, Heungil ; Kim, Hansung ; Kim, Young sun ; Choi, Kyu Sil ; Park, Hyunjin ; Seo, Jongbum. / Sonophoresis Using Ultrasound Contrast Agents for Transdermal Drug Delivery : An In Vivo Experimental Study. In: Ultrasound in Medicine and Biology. 2012 ; Vol. 38, No. 4. pp. 642-650.
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Sonophoresis Using Ultrasound Contrast Agents for Transdermal Drug Delivery : An In Vivo Experimental Study. / Park, Donghee; Ryu, Heungil; Kim, Hansung; Kim, Young sun; Choi, Kyu Sil; Park, Hyunjin; Seo, Jongbum.

In: Ultrasound in Medicine and Biology, Vol. 38, No. 4, 01.04.2012, p. 642-650.

Research output: Contribution to journalArticle

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