Sox2 contributes to tooth development via Wnt signaling

Min Jung Lee, Eun Jung Kim, Keishi Otsu, Hidemitsu Harada, Han Sung Jung

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The transcription factor Sox2 is a stem cell marker that dictates cell lineage. It has been shown to mark the epithelial stem cells of the continuously growing mouse incisors. Sox2 also interferes with Wnt signaling by binding to β-catenin, a central mediator of the Wnt pathway. We show that these functions of Sox2 are essential for mouse molar development. Sox2 has previously been shown to play a role in the formation of new teeth from the existing dental epithelium. To assess Sox2 function related to cell migration within a tooth, we monitored cell movement by using a DiI system and observed that DiI moves from molar 1 to molar 2 during tooth development. However, upon temporal knockdown of Sox2, DiI remains in the molar 1 region. This study also provides novel insights into the role of Sox2 and the important validation of Sox2 as a potent target in Wnt signaling during tooth development. Our data reveal that the degradation of Wnt signaling caused by the knockdown of Sox2 results in a lack of cell migration during tooth development.

Original languageEnglish
Pages (from-to)77-84
Number of pages8
JournalCell and Tissue Research
Volume365
Issue number1
DOIs
Publication statusPublished - 2016 Jul 1

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All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Histology
  • Cell Biology

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