Spatially adaptive image restoration for autoradiography

John A. Goyette, Moon G. Kang, Aggelos K. Katsaggelos, Gregory D. Lapin

Research output: Chapter in Book/Report/Conference proceedingConference contribution

6 Citations (Scopus)

Abstract

In this paper, we present a model that is used to improve the resolution of autoradiographic images. The model involves a point spread function (PSF) due to the radiated pattern of emitted photons combined with a signal-dependent noise source due to the granularity of x-ray recording film. A theoretical expression for the PSF is presented, and experimental measurements are performed using 51Cr microspheres. An iterative regularized image restoration algorithm is developed using a weighting matrix to incorporate the signal-dependent nature of the noise. Since information about the original undegraded image is not completely available, we make use of a regularization functional that is updated at each iteration to optimize the solution process. Our experimental results indicate that the resolution of autoradiographic images is improved by 43% using this algorithm.

Original languageEnglish
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
Pages811-822
Number of pages12
Edition2
Publication statusPublished - 1995 Dec 1
EventOptical Engineering Midwest'95. Part 2 (of 2) - Chicago, IL, USA
Duration: 1995 May 181995 May 19

Publication series

NameProceedings of SPIE - The International Society for Optical Engineering
Number2
Volume2622
ISSN (Print)0277-786X

Other

OtherOptical Engineering Midwest'95. Part 2 (of 2)
CityChicago, IL, USA
Period95/5/1895/5/19

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All Science Journal Classification (ASJC) codes

  • Electronic, Optical and Magnetic Materials
  • Condensed Matter Physics
  • Computer Science Applications
  • Applied Mathematics
  • Electrical and Electronic Engineering

Cite this

Goyette, J. A., Kang, M. G., Katsaggelos, A. K., & Lapin, G. D. (1995). Spatially adaptive image restoration for autoradiography. In Proceedings of SPIE - The International Society for Optical Engineering (2 ed., pp. 811-822). (Proceedings of SPIE - The International Society for Optical Engineering; Vol. 2622, No. 2).