Spatiotemporal variations of magnetic susceptibility in the deep gray matter nuclei from 1 month to 6 years: A quantitative susceptibility mapping study

Ning Ning; Congcong Liu; Peng Wu; Yajie Hu; Weishan Zhang; Lei Zhang; Mengxuan Li; Sung Min Gho; Dong Hyun Kim; Hua Guo; Jian Yang; Chao Jin

doi:10.1002/jmri.26579

Spatiotemporal variations of magnetic susceptibility in the deep gray matter nuclei from 1 month to 6 years: A quantitative susceptibility mapping study

Ning Ning, Congcong Liu, Peng Wu, Yajie Hu, Weishan Zhang, Lei Zhang, Mengxuan Li, Sung Min Gho, Dong Hyun Kim, Hua Guo, Jian Yang, Chao Jin

Department of Electrical and Electronic Engineering

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

Background: Quantitative susceptibility mapping (QSM) is emerging as a technique that quantifies the paramagnetic nonheme iron in brain tissue. Brain iron quantification during early development provides insights into the underlying mechanism of brain maturation. Purpose: To quantify the spatiotemporal variations of brain iron-related magnetic susceptibility in deep gray matter nuclei during early development by using QSM. Study Type: Retrospective. Subjects: Eighty-seven infants and children aged 1 month to 6 years. Field Strength/Sequence: Enhanced T ₂ *-weighted angiography using a 3D gradient-echo sequence at 3.0T. Assessment: QSM was calculated by modified sophisticated harmonic artifact reduction for phase data and sparse linear equations and sparse least squares-based algorithm. Means of susceptibility in deep gray matter nuclei (caudate nucleus, putamen, globus pallidus, thalamus) relative to that in splenium of corpus callosum were measured. Statistical Tests: Relationships of mean susceptibility with age and referenced iron concentration were tested by Pearson correlation. Differences of mean susceptibility between the selected nuclei in each age group were compared by one-way analysis of variance (ANOVA) and Fisher's Linear Significant Difference (LSD) test. Results: Positive correlations of susceptibility with both referenced iron concentration and age were found (P < 0.0001); particularly, globus pallidus showed the highest correlation with age (correlation coefficient, 0.882; slope, 1.203; P < 0.001) and greatest susceptibility (P < 0.05) among the selected nuclei. Data Conclusion: QSM allows the feasible quantification of iron deposition in deep gray matter nuclei in infants and young children, which exhibited gradual accumulation at different speeds. The fastest and highest iron accumulation was observed in the globus pallidus with increasing age during early development. Level of Evidence: 4. Technical Efficacy:Stage 2. J. Magn. Reson. Imaging 2018.

Original language	English
Pages (from-to)	1600-1609
Number of pages	10
Journal	Journal of Magnetic Resonance Imaging
Volume	49
Issue number	6
DOIs	https://doi.org/10.1002/jmri.26579
Publication status	Published - 2019 Jun

Bibliographical note

Funding Information:
We are appreciated for the statistical help by Dr. Jie Zheng from Clinical Research Center, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, P.R. China. Contract grant sponsor: National Key Research and Development Program of China; Contract grant sponsor: 2016YFC0100300; Contract grant sponsor: National Natural Science Foundation of China; Contract grant numbers: 81171317, 81471631, 81771810, 51706178; Contract grant sponsor: 2011 New Century Excellent Talent Support Plan of the Ministry of Education, China; Contract grant number: NCET-11-0438; Contract grant sponsor: China Postdoctoral Science Foundation; Contract grant number: 2017M613145; Contract grant sponsor: Shaanxi Provincial Natural Science Foundation for Youths of China; Contract grant number: 2017JQ8005; Clinical Research Award of the First Affiliated Hospital of Xi'an Jiaotong University; Contract grant number: XJTU1AF-CRF-2015-004.

Funding Information:
We are appreciated for the statistical help by Dr. Jie Zheng from Clinical Research Center, First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, P.R. China. Contract grant sponsor: National Key Research and Development Program of China; Contract grant sponsor: 2016YFC0100300; Contract grant sponsor: National Natural Science Foundation of China; Contract grant numbers: 81171317, 81471631, 81771810, 51706178; Contract grant sponsor: 2011 New Century Excellent Talent Support Plan of the Ministry of Education, China; Contract grant number: NCET-11-0438; Contract grant sponsor: China Postdoctoral Science Foundation; Contract grant number: 2017M613145; Contract grant sponsor: Shaanxi Provincial Natural Science Foundation for Youths of China; Contract grant number: 2017JQ8005; Clinical Research Award of the First Affiliated Hospital of Xi’an Jiaotong University; Contract grant number: XJTU1AF-CRF-2015-004.

Publisher Copyright:
© 2018 International Society for Magnetic Resonance in Medicine

All Science Journal Classification (ASJC) codes

Radiology Nuclear Medicine and imaging

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10.1002/jmri.26579

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Ning, N., Liu, C., Wu, P., Hu, Y., Zhang, W., Zhang, L., Li, M., Gho, S. M., Kim, D. H., Guo, H., Yang, J., & Jin, C. (2019). Spatiotemporal variations of magnetic susceptibility in the deep gray matter nuclei from 1 month to 6 years: A quantitative susceptibility mapping study. Journal of Magnetic Resonance Imaging, 49(6), 1600-1609. https://doi.org/10.1002/jmri.26579

@article{3c3d4732e75347b8812f27b1fdcaf128,

title = "Spatiotemporal variations of magnetic susceptibility in the deep gray matter nuclei from 1 month to 6 years: A quantitative susceptibility mapping study",

abstract = " Background: Quantitative susceptibility mapping (QSM) is emerging as a technique that quantifies the paramagnetic nonheme iron in brain tissue. Brain iron quantification during early development provides insights into the underlying mechanism of brain maturation. Purpose: To quantify the spatiotemporal variations of brain iron-related magnetic susceptibility in deep gray matter nuclei during early development by using QSM. Study Type: Retrospective. Subjects: Eighty-seven infants and children aged 1 month to 6 years. Field Strength/Sequence: Enhanced T 2 *-weighted angiography using a 3D gradient-echo sequence at 3.0T. Assessment: QSM was calculated by modified sophisticated harmonic artifact reduction for phase data and sparse linear equations and sparse least squares-based algorithm. Means of susceptibility in deep gray matter nuclei (caudate nucleus, putamen, globus pallidus, thalamus) relative to that in splenium of corpus callosum were measured. Statistical Tests: Relationships of mean susceptibility with age and referenced iron concentration were tested by Pearson correlation. Differences of mean susceptibility between the selected nuclei in each age group were compared by one-way analysis of variance (ANOVA) and Fisher's Linear Significant Difference (LSD) test. Results: Positive correlations of susceptibility with both referenced iron concentration and age were found (P < 0.0001); particularly, globus pallidus showed the highest correlation with age (correlation coefficient, 0.882; slope, 1.203; P < 0.001) and greatest susceptibility (P < 0.05) among the selected nuclei. Data Conclusion: QSM allows the feasible quantification of iron deposition in deep gray matter nuclei in infants and young children, which exhibited gradual accumulation at different speeds. The fastest and highest iron accumulation was observed in the globus pallidus with increasing age during early development. Level of Evidence: 4. Technical Efficacy:Stage 2. J. Magn. Reson. Imaging 2018.",

author = "Ning Ning and Congcong Liu and Peng Wu and Yajie Hu and Weishan Zhang and Lei Zhang and Mengxuan Li and Gho, {Sung Min} and Kim, {Dong Hyun} and Hua Guo and Jian Yang and Chao Jin",

note = "Funding Information: We are appreciated for the statistical help by Dr. Jie Zheng from Clinical Research Center, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, P.R. China. Contract grant sponsor: National Key Research and Development Program of China; Contract grant sponsor: 2016YFC0100300; Contract grant sponsor: National Natural Science Foundation of China; Contract grant numbers: 81171317, 81471631, 81771810, 51706178; Contract grant sponsor: 2011 New Century Excellent Talent Support Plan of the Ministry of Education, China; Contract grant number: NCET-11-0438; Contract grant sponsor: China Postdoctoral Science Foundation; Contract grant number: 2017M613145; Contract grant sponsor: Shaanxi Provincial Natural Science Foundation for Youths of China; Contract grant number: 2017JQ8005; Clinical Research Award of the First Affiliated Hospital of Xi'an Jiaotong University; Contract grant number: XJTU1AF-CRF-2015-004. Funding Information: We are appreciated for the statistical help by Dr. Jie Zheng from Clinical Research Center, First Affiliated Hospital of Xi{\textquoteright}an Jiaotong University, Xi{\textquoteright}an, P.R. China. Contract grant sponsor: National Key Research and Development Program of China; Contract grant sponsor: 2016YFC0100300; Contract grant sponsor: National Natural Science Foundation of China; Contract grant numbers: 81171317, 81471631, 81771810, 51706178; Contract grant sponsor: 2011 New Century Excellent Talent Support Plan of the Ministry of Education, China; Contract grant number: NCET-11-0438; Contract grant sponsor: China Postdoctoral Science Foundation; Contract grant number: 2017M613145; Contract grant sponsor: Shaanxi Provincial Natural Science Foundation for Youths of China; Contract grant number: 2017JQ8005; Clinical Research Award of the First Affiliated Hospital of Xi{\textquoteright}an Jiaotong University; Contract grant number: XJTU1AF-CRF-2015-004. Publisher Copyright: {\textcopyright} 2018 International Society for Magnetic Resonance in Medicine",

year = "2019",

month = jun,

doi = "10.1002/jmri.26579",

language = "English",

volume = "49",

pages = "1600--1609",

journal = "Journal of Magnetic Resonance Imaging",

issn = "1053-1807",

publisher = "John Wiley and Sons Inc.",

number = "6",

}

TY - JOUR

T1 - Spatiotemporal variations of magnetic susceptibility in the deep gray matter nuclei from 1 month to 6 years

T2 - A quantitative susceptibility mapping study

AU - Ning, Ning

AU - Liu, Congcong

AU - Wu, Peng

AU - Hu, Yajie

AU - Zhang, Weishan

AU - Zhang, Lei

AU - Li, Mengxuan

AU - Gho, Sung Min

AU - Kim, Dong Hyun

AU - Guo, Hua

AU - Yang, Jian

AU - Jin, Chao

N1 - Funding Information: We are appreciated for the statistical help by Dr. Jie Zheng from Clinical Research Center, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, P.R. China. Contract grant sponsor: National Key Research and Development Program of China; Contract grant sponsor: 2016YFC0100300; Contract grant sponsor: National Natural Science Foundation of China; Contract grant numbers: 81171317, 81471631, 81771810, 51706178; Contract grant sponsor: 2011 New Century Excellent Talent Support Plan of the Ministry of Education, China; Contract grant number: NCET-11-0438; Contract grant sponsor: China Postdoctoral Science Foundation; Contract grant number: 2017M613145; Contract grant sponsor: Shaanxi Provincial Natural Science Foundation for Youths of China; Contract grant number: 2017JQ8005; Clinical Research Award of the First Affiliated Hospital of Xi'an Jiaotong University; Contract grant number: XJTU1AF-CRF-2015-004. Funding Information: We are appreciated for the statistical help by Dr. Jie Zheng from Clinical Research Center, First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, P.R. China. Contract grant sponsor: National Key Research and Development Program of China; Contract grant sponsor: 2016YFC0100300; Contract grant sponsor: National Natural Science Foundation of China; Contract grant numbers: 81171317, 81471631, 81771810, 51706178; Contract grant sponsor: 2011 New Century Excellent Talent Support Plan of the Ministry of Education, China; Contract grant number: NCET-11-0438; Contract grant sponsor: China Postdoctoral Science Foundation; Contract grant number: 2017M613145; Contract grant sponsor: Shaanxi Provincial Natural Science Foundation for Youths of China; Contract grant number: 2017JQ8005; Clinical Research Award of the First Affiliated Hospital of Xi’an Jiaotong University; Contract grant number: XJTU1AF-CRF-2015-004. Publisher Copyright: © 2018 International Society for Magnetic Resonance in Medicine

PY - 2019/6

Y1 - 2019/6

N2 - Background: Quantitative susceptibility mapping (QSM) is emerging as a technique that quantifies the paramagnetic nonheme iron in brain tissue. Brain iron quantification during early development provides insights into the underlying mechanism of brain maturation. Purpose: To quantify the spatiotemporal variations of brain iron-related magnetic susceptibility in deep gray matter nuclei during early development by using QSM. Study Type: Retrospective. Subjects: Eighty-seven infants and children aged 1 month to 6 years. Field Strength/Sequence: Enhanced T 2 *-weighted angiography using a 3D gradient-echo sequence at 3.0T. Assessment: QSM was calculated by modified sophisticated harmonic artifact reduction for phase data and sparse linear equations and sparse least squares-based algorithm. Means of susceptibility in deep gray matter nuclei (caudate nucleus, putamen, globus pallidus, thalamus) relative to that in splenium of corpus callosum were measured. Statistical Tests: Relationships of mean susceptibility with age and referenced iron concentration were tested by Pearson correlation. Differences of mean susceptibility between the selected nuclei in each age group were compared by one-way analysis of variance (ANOVA) and Fisher's Linear Significant Difference (LSD) test. Results: Positive correlations of susceptibility with both referenced iron concentration and age were found (P < 0.0001); particularly, globus pallidus showed the highest correlation with age (correlation coefficient, 0.882; slope, 1.203; P < 0.001) and greatest susceptibility (P < 0.05) among the selected nuclei. Data Conclusion: QSM allows the feasible quantification of iron deposition in deep gray matter nuclei in infants and young children, which exhibited gradual accumulation at different speeds. The fastest and highest iron accumulation was observed in the globus pallidus with increasing age during early development. Level of Evidence: 4. Technical Efficacy:Stage 2. J. Magn. Reson. Imaging 2018.

AB - Background: Quantitative susceptibility mapping (QSM) is emerging as a technique that quantifies the paramagnetic nonheme iron in brain tissue. Brain iron quantification during early development provides insights into the underlying mechanism of brain maturation. Purpose: To quantify the spatiotemporal variations of brain iron-related magnetic susceptibility in deep gray matter nuclei during early development by using QSM. Study Type: Retrospective. Subjects: Eighty-seven infants and children aged 1 month to 6 years. Field Strength/Sequence: Enhanced T 2 *-weighted angiography using a 3D gradient-echo sequence at 3.0T. Assessment: QSM was calculated by modified sophisticated harmonic artifact reduction for phase data and sparse linear equations and sparse least squares-based algorithm. Means of susceptibility in deep gray matter nuclei (caudate nucleus, putamen, globus pallidus, thalamus) relative to that in splenium of corpus callosum were measured. Statistical Tests: Relationships of mean susceptibility with age and referenced iron concentration were tested by Pearson correlation. Differences of mean susceptibility between the selected nuclei in each age group were compared by one-way analysis of variance (ANOVA) and Fisher's Linear Significant Difference (LSD) test. Results: Positive correlations of susceptibility with both referenced iron concentration and age were found (P < 0.0001); particularly, globus pallidus showed the highest correlation with age (correlation coefficient, 0.882; slope, 1.203; P < 0.001) and greatest susceptibility (P < 0.05) among the selected nuclei. Data Conclusion: QSM allows the feasible quantification of iron deposition in deep gray matter nuclei in infants and young children, which exhibited gradual accumulation at different speeds. The fastest and highest iron accumulation was observed in the globus pallidus with increasing age during early development. Level of Evidence: 4. Technical Efficacy:Stage 2. J. Magn. Reson. Imaging 2018.

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Spatiotemporal variations of magnetic susceptibility in the deep gray matter nuclei from 1 month to 6 years: A quantitative susceptibility mapping study

Abstract

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