Specialized cavitation seed for sonophoresis

G. S. Song, J. H. Kim, O. R. Cha, U. C. Shin, Jongbum Seo

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Sonphoresis can increase skin permeability to various drugs in transdermal drug delivery (TDD) and cavitation is recognized as the predominant mechanism of sonophoresis. In order to increase cavitation activity on the skin surface, dense liquid phase gas core cavitation seed was designed instead of commercially available ultrasound contrast agents (UCAs). The effect of specialized cavitation seed in sonophoresis was quantitatively analyzed with high performance liquid chromatography. Ferulic acid was used as target drug molecule to be delivered into porcine skin. The results indicate that specialized cavitation seed can increase the amount of delivered ferulic acid approximately 2,000 folds while a commercial UCA does not improve the efficiency of TDD. We expect the developed specialized cavitation seeds could be used widely for various skin related applications.

Original languageEnglish
Title of host publication2016 IEEE International Ultrasonics Symposium, IUS 2016
PublisherIEEE Computer Society
Volume2016-November
ISBN (Electronic)9781467398978
DOIs
Publication statusPublished - 2016 Nov 1
Event2016 IEEE International Ultrasonics Symposium, IUS 2016 - Tours, France
Duration: 2016 Sep 182016 Sep 21

Other

Other2016 IEEE International Ultrasonics Symposium, IUS 2016
CountryFrance
CityTours
Period16/9/1816/9/21

Fingerprint

cavitation flow
seeds
drugs
delivery
acids
liquid chromatography
permeability
liquid phases
gases
molecules

All Science Journal Classification (ASJC) codes

  • Acoustics and Ultrasonics

Cite this

Song, G. S., Kim, J. H., Cha, O. R., Shin, U. C., & Seo, J. (2016). Specialized cavitation seed for sonophoresis. In 2016 IEEE International Ultrasonics Symposium, IUS 2016 (Vol. 2016-November). [7728551] IEEE Computer Society. https://doi.org/10.1109/ULTSYM.2016.7728551
Song, G. S. ; Kim, J. H. ; Cha, O. R. ; Shin, U. C. ; Seo, Jongbum. / Specialized cavitation seed for sonophoresis. 2016 IEEE International Ultrasonics Symposium, IUS 2016. Vol. 2016-November IEEE Computer Society, 2016.
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Song, GS, Kim, JH, Cha, OR, Shin, UC & Seo, J 2016, Specialized cavitation seed for sonophoresis. in 2016 IEEE International Ultrasonics Symposium, IUS 2016. vol. 2016-November, 7728551, IEEE Computer Society, 2016 IEEE International Ultrasonics Symposium, IUS 2016, Tours, France, 16/9/18. https://doi.org/10.1109/ULTSYM.2016.7728551

Specialized cavitation seed for sonophoresis. / Song, G. S.; Kim, J. H.; Cha, O. R.; Shin, U. C.; Seo, Jongbum.

2016 IEEE International Ultrasonics Symposium, IUS 2016. Vol. 2016-November IEEE Computer Society, 2016. 7728551.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

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AB - Sonphoresis can increase skin permeability to various drugs in transdermal drug delivery (TDD) and cavitation is recognized as the predominant mechanism of sonophoresis. In order to increase cavitation activity on the skin surface, dense liquid phase gas core cavitation seed was designed instead of commercially available ultrasound contrast agents (UCAs). The effect of specialized cavitation seed in sonophoresis was quantitatively analyzed with high performance liquid chromatography. Ferulic acid was used as target drug molecule to be delivered into porcine skin. The results indicate that specialized cavitation seed can increase the amount of delivered ferulic acid approximately 2,000 folds while a commercial UCA does not improve the efficiency of TDD. We expect the developed specialized cavitation seeds could be used widely for various skin related applications.

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Song GS, Kim JH, Cha OR, Shin UC, Seo J. Specialized cavitation seed for sonophoresis. In 2016 IEEE International Ultrasonics Symposium, IUS 2016. Vol. 2016-November. IEEE Computer Society. 2016. 7728551 https://doi.org/10.1109/ULTSYM.2016.7728551