Specialized cavitation seed for sonophoresis

G. S. Song, J. H. Kim, O. R. Cha, U. C. Shin, J. Seo

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Citation (Scopus)


Sonphoresis can increase skin permeability to various drugs in transdermal drug delivery (TDD) and cavitation is recognized as the predominant mechanism of sonophoresis. In order to increase cavitation activity on the skin surface, dense liquid phase gas core cavitation seed was designed instead of commercially available ultrasound contrast agents (UCAs). The effect of specialized cavitation seed in sonophoresis was quantitatively analyzed with high performance liquid chromatography. Ferulic acid was used as target drug molecule to be delivered into porcine skin. The results indicate that specialized cavitation seed can increase the amount of delivered ferulic acid approximately 2,000 folds while a commercial UCA does not improve the efficiency of TDD. We expect the developed specialized cavitation seeds could be used widely for various skin related applications.

Original languageEnglish
Title of host publication2016 IEEE International Ultrasonics Symposium, IUS 2016
PublisherIEEE Computer Society
ISBN (Electronic)9781467398978
Publication statusPublished - 2016 Nov 1
Event2016 IEEE International Ultrasonics Symposium, IUS 2016 - Tours, France
Duration: 2016 Sept 182016 Sept 21

Publication series

NameIEEE International Ultrasonics Symposium, IUS
ISSN (Print)1948-5719
ISSN (Electronic)1948-5727


Other2016 IEEE International Ultrasonics Symposium, IUS 2016

Bibliographical note

Publisher Copyright:
© 2016 IEEE.

All Science Journal Classification (ASJC) codes

  • Acoustics and Ultrasonics


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