Species distribution and macrolide susceptibility of mycobacterium fortuitum complex clinical isolates

Su Young Kim, Seong Mi Moon, Byung Woo Jhun, O. Jung Kwon, Hee Jae Huh, Nam Yong Lee, Seung Heon Lee, Sung Jae Shin, Shannon H. Kasperbauer, Gwen A. Huitt, Charles L. Daley, Won Jung Koh

Research output: Contribution to journalArticle

Abstract

The understanding of species distribution and inducible macrolide resistance in the Mycobacterium fortuitum complex (MFC) is limited. Of 90 mostly respiratory MFC clinical isolates, half were M. fortuitum, followed by M. peregrinum, M. porcinum, M. septicum, and M. conceptionense. Most M. fortuitum, M. porcinum, and M. septicum isolates were inducibly resistant to clarithromycin, whereas two-thirds of the M. peregrinum isolates were clarithromycin susceptible. Clarithromycin-resistant M. fortuitum isolates exhibited common mutations of erm(39), potentially involved in clarithromycin resistance.

Original languageEnglish
Article numbere02331-18
JournalAntimicrobial agents and chemotherapy
Volume63
Issue number6
DOIs
Publication statusPublished - 2019 Jun

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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    Kim, S. Y., Moon, S. M., Jhun, B. W., Jung Kwon, O., Huh, H. J., Lee, N. Y., Lee, S. H., Shin, S. J., Kasperbauer, S. H., Huitt, G. A., Daley, C. L., & Koh, W. J. (2019). Species distribution and macrolide susceptibility of mycobacterium fortuitum complex clinical isolates. Antimicrobial agents and chemotherapy, 63(6), [e02331-18]. https://doi.org/10.1128/AAC.02331-18