Species distribution and macrolide susceptibility of mycobacterium fortuitum complex clinical isolates

Su Young Kim, Seong Mi Moon, Byung Woo Jhun, O. Jung Kwon, Hee Jae Huh, Nam Yong Lee, Seung Heon Lee, SungJae Shin, Shannon H. Kasperbauer, Gwen A. Huitt, Charles L. Daley, Won Jung Koh

Research output: Contribution to journalArticle

Abstract

The understanding of species distribution and inducible macrolide resistance in the Mycobacterium fortuitum complex (MFC) is limited. Of 90 mostly respiratory MFC clinical isolates, half were M. fortuitum, followed by M. peregrinum, M. porcinum, M. septicum, and M. conceptionense. Most M. fortuitum, M. porcinum, and M. septicum isolates were inducibly resistant to clarithromycin, whereas two-thirds of the M. peregrinum isolates were clarithromycin susceptible. Clarithromycin-resistant M. fortuitum isolates exhibited common mutations of erm(39), potentially involved in clarithromycin resistance.

Original languageEnglish
Article numbere02331-18
JournalAntimicrobial agents and chemotherapy
Volume63
Issue number6
DOIs
Publication statusPublished - 2019 Jun 1

Fingerprint

Mycobacterium fortuitum
Macrolides
Clarithromycin
Mutation

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

Cite this

Kim, S. Y., Moon, S. M., Jhun, B. W., Jung Kwon, O., Huh, H. J., Lee, N. Y., ... Koh, W. J. (2019). Species distribution and macrolide susceptibility of mycobacterium fortuitum complex clinical isolates. Antimicrobial agents and chemotherapy, 63(6), [e02331-18]. https://doi.org/10.1128/AAC.02331-18
Kim, Su Young ; Moon, Seong Mi ; Jhun, Byung Woo ; Jung Kwon, O. ; Huh, Hee Jae ; Lee, Nam Yong ; Lee, Seung Heon ; Shin, SungJae ; Kasperbauer, Shannon H. ; Huitt, Gwen A. ; Daley, Charles L. ; Koh, Won Jung. / Species distribution and macrolide susceptibility of mycobacterium fortuitum complex clinical isolates. In: Antimicrobial agents and chemotherapy. 2019 ; Vol. 63, No. 6.
@article{f3c521523a9b4dd7ab010fc230cae316,
title = "Species distribution and macrolide susceptibility of mycobacterium fortuitum complex clinical isolates",
abstract = "The understanding of species distribution and inducible macrolide resistance in the Mycobacterium fortuitum complex (MFC) is limited. Of 90 mostly respiratory MFC clinical isolates, half were M. fortuitum, followed by M. peregrinum, M. porcinum, M. septicum, and M. conceptionense. Most M. fortuitum, M. porcinum, and M. septicum isolates were inducibly resistant to clarithromycin, whereas two-thirds of the M. peregrinum isolates were clarithromycin susceptible. Clarithromycin-resistant M. fortuitum isolates exhibited common mutations of erm(39), potentially involved in clarithromycin resistance.",
author = "Kim, {Su Young} and Moon, {Seong Mi} and Jhun, {Byung Woo} and {Jung Kwon}, O. and Huh, {Hee Jae} and Lee, {Nam Yong} and Lee, {Seung Heon} and SungJae Shin and Kasperbauer, {Shannon H.} and Huitt, {Gwen A.} and Daley, {Charles L.} and Koh, {Won Jung}",
year = "2019",
month = "6",
day = "1",
doi = "10.1128/AAC.02331-18",
language = "English",
volume = "63",
journal = "Antimicrobial Agents and Chemotherapy",
issn = "0066-4804",
publisher = "American Society for Microbiology",
number = "6",

}

Kim, SY, Moon, SM, Jhun, BW, Jung Kwon, O, Huh, HJ, Lee, NY, Lee, SH, Shin, S, Kasperbauer, SH, Huitt, GA, Daley, CL & Koh, WJ 2019, 'Species distribution and macrolide susceptibility of mycobacterium fortuitum complex clinical isolates', Antimicrobial agents and chemotherapy, vol. 63, no. 6, e02331-18. https://doi.org/10.1128/AAC.02331-18

Species distribution and macrolide susceptibility of mycobacterium fortuitum complex clinical isolates. / Kim, Su Young; Moon, Seong Mi; Jhun, Byung Woo; Jung Kwon, O.; Huh, Hee Jae; Lee, Nam Yong; Lee, Seung Heon; Shin, SungJae; Kasperbauer, Shannon H.; Huitt, Gwen A.; Daley, Charles L.; Koh, Won Jung.

In: Antimicrobial agents and chemotherapy, Vol. 63, No. 6, e02331-18, 01.06.2019.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Species distribution and macrolide susceptibility of mycobacterium fortuitum complex clinical isolates

AU - Kim, Su Young

AU - Moon, Seong Mi

AU - Jhun, Byung Woo

AU - Jung Kwon, O.

AU - Huh, Hee Jae

AU - Lee, Nam Yong

AU - Lee, Seung Heon

AU - Shin, SungJae

AU - Kasperbauer, Shannon H.

AU - Huitt, Gwen A.

AU - Daley, Charles L.

AU - Koh, Won Jung

PY - 2019/6/1

Y1 - 2019/6/1

N2 - The understanding of species distribution and inducible macrolide resistance in the Mycobacterium fortuitum complex (MFC) is limited. Of 90 mostly respiratory MFC clinical isolates, half were M. fortuitum, followed by M. peregrinum, M. porcinum, M. septicum, and M. conceptionense. Most M. fortuitum, M. porcinum, and M. septicum isolates were inducibly resistant to clarithromycin, whereas two-thirds of the M. peregrinum isolates were clarithromycin susceptible. Clarithromycin-resistant M. fortuitum isolates exhibited common mutations of erm(39), potentially involved in clarithromycin resistance.

AB - The understanding of species distribution and inducible macrolide resistance in the Mycobacterium fortuitum complex (MFC) is limited. Of 90 mostly respiratory MFC clinical isolates, half were M. fortuitum, followed by M. peregrinum, M. porcinum, M. septicum, and M. conceptionense. Most M. fortuitum, M. porcinum, and M. septicum isolates were inducibly resistant to clarithromycin, whereas two-thirds of the M. peregrinum isolates were clarithromycin susceptible. Clarithromycin-resistant M. fortuitum isolates exhibited common mutations of erm(39), potentially involved in clarithromycin resistance.

UR - http://www.scopus.com/inward/record.url?scp=85066424301&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85066424301&partnerID=8YFLogxK

U2 - 10.1128/AAC.02331-18

DO - 10.1128/AAC.02331-18

M3 - Article

VL - 63

JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

SN - 0066-4804

IS - 6

M1 - e02331-18

ER -