Specific immunotherapy in atopic dermatitis

Jungsoo Lee, Chang Ook Park, Kwang Hoon Lee

Research output: Contribution to journalReview article

25 Citations (Scopus)

Abstract

Allergen specific immunotherapy (SIT) using house dust mite (HDM) extracts has been performed mainly with patients of asthma and allergic rhinitis. In the meanwhile, there has been a long debate on the efficacy of SIT in atopic dermatitis (AD) with only a few double-blind placebo-controlled trials. However, several randomized controlled trials of SIT in AD revealed significant improvement of clinical symptoms and also, positive result was shown by a following meta-analysis study of these trials. In order to predict and evaluate the treatment outcome, finding a biomarker that can predict treatment responses and treatment end-points is critical but it is very challenging at the same time due to the complexity of causes and mechanisms of AD. Other considerations including standardization of the easiest and safest treatment protocol and optimizing the treatment preparations should be studied as well. This review summarizes the basics of SIT in AD including the brief mechanisms, treatment methods and schedules, and also highlights the clinical efficacy of SIT in AD along with mild, controllable adverse reactions. Immunologic effects and studies of various biomarkers are also introduced and finally, future considerations with upcoming studies on SIT were discussed.

Original languageEnglish
Pages (from-to)221-229
Number of pages9
JournalAllergy, Asthma and Immunology Research
Volume7
Issue number3
DOIs
Publication statusPublished - 2015 Jan 1

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Atopic Dermatitis
Immunotherapy
Biomarkers
Immunologic Desensitization
Pyroglyphidae
Therapeutics
Clinical Protocols
Meta-Analysis
Appointments and Schedules
Asthma
Randomized Controlled Trials
Placebos

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology
  • Pulmonary and Respiratory Medicine

Cite this

Lee, Jungsoo ; Park, Chang Ook ; Lee, Kwang Hoon. / Specific immunotherapy in atopic dermatitis. In: Allergy, Asthma and Immunology Research. 2015 ; Vol. 7, No. 3. pp. 221-229.
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Specific immunotherapy in atopic dermatitis. / Lee, Jungsoo; Park, Chang Ook; Lee, Kwang Hoon.

In: Allergy, Asthma and Immunology Research, Vol. 7, No. 3, 01.01.2015, p. 221-229.

Research output: Contribution to journalReview article

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AB - Allergen specific immunotherapy (SIT) using house dust mite (HDM) extracts has been performed mainly with patients of asthma and allergic rhinitis. In the meanwhile, there has been a long debate on the efficacy of SIT in atopic dermatitis (AD) with only a few double-blind placebo-controlled trials. However, several randomized controlled trials of SIT in AD revealed significant improvement of clinical symptoms and also, positive result was shown by a following meta-analysis study of these trials. In order to predict and evaluate the treatment outcome, finding a biomarker that can predict treatment responses and treatment end-points is critical but it is very challenging at the same time due to the complexity of causes and mechanisms of AD. Other considerations including standardization of the easiest and safest treatment protocol and optimizing the treatment preparations should be studied as well. This review summarizes the basics of SIT in AD including the brief mechanisms, treatment methods and schedules, and also highlights the clinical efficacy of SIT in AD along with mild, controllable adverse reactions. Immunologic effects and studies of various biomarkers are also introduced and finally, future considerations with upcoming studies on SIT were discussed.

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