Spectral-domain optical coherence phase microscopy for quantitative phase-contrast imaging

Chulmin Joo, Taner Akkin, Barry Cense, Boris H. Park, Johannes F. De Boer

Research output: Contribution to journalArticle

206 Citations (Scopus)

Abstract

We describe a novel microscopy technique for quantitative phase-contrast imaging of a transparent specimen. The technique is based on depth-resolved phase information provided by common path spectral-domain optical coherence tomography and can measure minute phase variations caused by changes in refractive index and thickness inside the specimen. We demonstrate subnanometer level path-length sensitivity and present images obtained on reflection from a known phase object and human epithelial cheek cells.

Original languageEnglish
Pages (from-to)2131-2133
Number of pages3
JournalOptics Letters
Volume30
Issue number16
DOIs
Publication statusPublished - 2005 Aug 15

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phase coherence
phase contrast
microscopy
tomography
refractivity
sensitivity
cells

All Science Journal Classification (ASJC) codes

  • Atomic and Molecular Physics, and Optics

Cite this

Joo, Chulmin ; Akkin, Taner ; Cense, Barry ; Park, Boris H. ; De Boer, Johannes F. / Spectral-domain optical coherence phase microscopy for quantitative phase-contrast imaging. In: Optics Letters. 2005 ; Vol. 30, No. 16. pp. 2131-2133.
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Spectral-domain optical coherence phase microscopy for quantitative phase-contrast imaging. / Joo, Chulmin; Akkin, Taner; Cense, Barry; Park, Boris H.; De Boer, Johannes F.

In: Optics Letters, Vol. 30, No. 16, 15.08.2005, p. 2131-2133.

Research output: Contribution to journalArticle

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