Sphingomyelin-based liposomes with different cholesterol contents and polydopamine coating as a controlled delivery system

Eun Bi Lim, Seungjoo Haam, Sang Wha Lee

Research output: Contribution to journalArticlepeer-review

Abstract

Sphingomyelin (SM)-based liposomes (SMLs) exhibited different loading and release behaviors of encapsulated drugs, depending on cholesterol contents and polydopamine (PDA) coating layer. Herein, three SMLs with different compositions were formulated by intercalating the cholesterol contents (40%, 50%, and 60%) in the lipid bilayer. Then, the SMLs were further coated with a PDA layer, hereafter referred to as SMLs@PDA. In-vitro release test was carried out by loading ibuprofen (Ibu) and acetaminophen (Acet) into the SMLs. When increasing the cholesterol contents in the SMLs, the loading amount of hydrophobic ibuprofen was increased, due to the increased hydrophobic interactions between ibuprofen and cholesterol. On the other hand, the loading amount of hydrophilic acetaminophen was decreased at higher cholesterol content in the SMLs. The release rate of Ibu-loaded SMLs (SMLs-Ibu) was significantly decreased at the highest cholesterol content (60%), whereas the release rate of Acet-loaded SMLs (SMLs-Acet) was not significantly decreased at the highest cholesterol content. After coating the SMLs-Acet with the PDA layer (SMLs-Acet@PDA), the release rate of SMLs-Acet@PDA was significantly reduced, probably due to the strong π–π stacking interactions between the resonance structure of acetaminophen and aromatic π system of PDA layer, as well as the effective diffusion barrier by the thick PDA layer. The fast release kinetics of SML-drug system was predicted using the Fickian diffusion model, and the slow release kinetics was predicted by the Higuchi model. Our work can contribute a significant advance for preclinical development of lipid-based nanocarriers by demonstrating the release and loading relationships between encapsulated drugs and lipid compositions.

Original languageEnglish
Article number126447
JournalColloids and Surfaces A: Physicochemical and Engineering Aspects
Volume618
DOIs
Publication statusPublished - 2021 Jun 5

Bibliographical note

Funding Information:
This research was supported by the Bio and Medical Technology Development Program of the National Research Foundation (NRF) funded by the Ministry of Science and ICT, South Korea [ NRF-2018M3A9H4056340 ]. This study was supported by the Korea Institute of Energy Technology Evaluation and Planning (KETEP), and the Ministry of Trade, Industry and Energy (MOTIE) of the Republic of Korea [Grant No. 20194030202440 ].

Publisher Copyright:
© 2021 Elsevier B.V.

All Science Journal Classification (ASJC) codes

  • Surfaces and Interfaces
  • Physical and Theoretical Chemistry
  • Colloid and Surface Chemistry

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