Spirostanol saponins from Tacca vietnamensis and their anti-inflammatory activity

Pham Hai Yen; Vu Thi Quynh Chi; Phan Van Kiem; Bui Huu Tai; Tran Hong Quang; Nguyen Xuan Nhiem; Hoang Le Tuan Anh; Ninh Khac Ban; Bui Van Thanh; Chau Van Minh; Seon Ju Park; Seung Hyun Kim

doi:10.1016/j.bmcl.2016.05.048

Spirostanol saponins from Tacca vietnamensis and their anti-inflammatory activity

Pham Hai Yen, Vu Thi Quynh Chi, Phan Van Kiem, Bui Huu Tai, Tran Hong Quang, Nguyen Xuan Nhiem, Hoang Le Tuan Anh, Ninh Khac Ban, Bui Van Thanh, Chau Van Minh, Seon Ju Park, Seung Hyun Kim

Department of Pharmacy

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

Using various chromatographic methods, five new steroidal saponins named taccavietnamosides A–E (1–5) and three known, (24S,25R)-spirost-5-en-3β,24-diol 3-O-α-L-rhamnopyranosyl-(1→2)-[α-L-rhamnopyranosyl-(1→3)]-β-D-glucopyranoside (6), (24S,25R)-spirost-5-en-3β,24-diol 3-O-α-L-rhamnopyranosyl-(1→2)-[β-D-glucopyranosyl-(1→4)-α-L-rhamnopyranosyl-(1→3)]-β-D-glucopyranoside (7), and chantrieroside A (8) were isolated from the rhizomes of Tacca vietnamensis Thin et Hoat. Their chemical structures were elucidated by physical and chemical methods. All compounds were evaluated for the inhibitory activities of nitric oxide production in LPS-stimulated RAW 264.7 macrophages and BV2 cells. As the results, compounds 3–5 showed moderate inhibition on NO production in LPS-stimulated BV2 cells and RAW 264.7 macrophages with the IC₅₀values ranging from 37.0 to 60.7 μM.

Original language	English
Pages (from-to)	3780-3784
Number of pages	5
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	26
Issue number	15
DOIs	https://doi.org/10.1016/j.bmcl.2016.05.048
Publication status	Published - 2016

Bibliographical note

Funding Information:
This research is funded by Vietnam National Foundation for Science and Technology Development (NAFOSTED) under grant number 104.01-2012.22 and Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology ( NRF-2011-0025129 ).

Publisher Copyright:
© 2016 Elsevier Ltd

All Science Journal Classification (ASJC) codes

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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10.1016/j.bmcl.2016.05.048

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@article{0e5fdb816d3e45fe9afb9f8281057e9c,

title = "Spirostanol saponins from Tacca vietnamensis and their anti-inflammatory activity",

abstract = "Using various chromatographic methods, five new steroidal saponins named taccavietnamosides A–E (1–5) and three known, (24S,25R)-spirost-5-en-3β,24-diol 3-O-α-L-rhamnopyranosyl-(1→2)-[α-L-rhamnopyranosyl-(1→3)]-β-D-glucopyranoside (6), (24S,25R)-spirost-5-en-3β,24-diol 3-O-α-L-rhamnopyranosyl-(1→2)-[β-D-glucopyranosyl-(1→4)-α-L-rhamnopyranosyl-(1→3)]-β-D-glucopyranoside (7), and chantrieroside A (8) were isolated from the rhizomes of Tacca vietnamensis Thin et Hoat. Their chemical structures were elucidated by physical and chemical methods. All compounds were evaluated for the inhibitory activities of nitric oxide production in LPS-stimulated RAW 264.7 macrophages and BV2 cells. As the results, compounds 3–5 showed moderate inhibition on NO production in LPS-stimulated BV2 cells and RAW 264.7 macrophages with the IC50values ranging from 37.0 to 60.7 μM.",

author = "Yen, {Pham Hai} and Chi, {Vu Thi Quynh} and Kiem, {Phan Van} and Tai, {Bui Huu} and Quang, {Tran Hong} and Nhiem, {Nguyen Xuan} and Anh, {Hoang Le Tuan} and Ban, {Ninh Khac} and Thanh, {Bui Van} and Minh, {Chau Van} and Park, {Seon Ju} and Kim, {Seung Hyun}",

note = "Funding Information: This research is funded by Vietnam National Foundation for Science and Technology Development (NAFOSTED) under grant number 104.01-2012.22 and Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology ( NRF-2011-0025129 ). Publisher Copyright: {\textcopyright} 2016 Elsevier Ltd",

year = "2016",

doi = "10.1016/j.bmcl.2016.05.048",

language = "English",

volume = "26",

pages = "3780--3784",

journal = "Bioorganic and Medicinal Chemistry Letters",

issn = "0960-894X",

publisher = "Elsevier Limited",

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}

TY - JOUR

T1 - Spirostanol saponins from Tacca vietnamensis and their anti-inflammatory activity

AU - Yen, Pham Hai

AU - Chi, Vu Thi Quynh

AU - Kiem, Phan Van

AU - Tai, Bui Huu

AU - Quang, Tran Hong

AU - Nhiem, Nguyen Xuan

AU - Anh, Hoang Le Tuan

AU - Ban, Ninh Khac

AU - Thanh, Bui Van

AU - Minh, Chau Van

AU - Park, Seon Ju

AU - Kim, Seung Hyun

N1 - Funding Information: This research is funded by Vietnam National Foundation for Science and Technology Development (NAFOSTED) under grant number 104.01-2012.22 and Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology ( NRF-2011-0025129 ). Publisher Copyright: © 2016 Elsevier Ltd

PY - 2016

Y1 - 2016

N2 - Using various chromatographic methods, five new steroidal saponins named taccavietnamosides A–E (1–5) and three known, (24S,25R)-spirost-5-en-3β,24-diol 3-O-α-L-rhamnopyranosyl-(1→2)-[α-L-rhamnopyranosyl-(1→3)]-β-D-glucopyranoside (6), (24S,25R)-spirost-5-en-3β,24-diol 3-O-α-L-rhamnopyranosyl-(1→2)-[β-D-glucopyranosyl-(1→4)-α-L-rhamnopyranosyl-(1→3)]-β-D-glucopyranoside (7), and chantrieroside A (8) were isolated from the rhizomes of Tacca vietnamensis Thin et Hoat. Their chemical structures were elucidated by physical and chemical methods. All compounds were evaluated for the inhibitory activities of nitric oxide production in LPS-stimulated RAW 264.7 macrophages and BV2 cells. As the results, compounds 3–5 showed moderate inhibition on NO production in LPS-stimulated BV2 cells and RAW 264.7 macrophages with the IC50values ranging from 37.0 to 60.7 μM.

AB - Using various chromatographic methods, five new steroidal saponins named taccavietnamosides A–E (1–5) and three known, (24S,25R)-spirost-5-en-3β,24-diol 3-O-α-L-rhamnopyranosyl-(1→2)-[α-L-rhamnopyranosyl-(1→3)]-β-D-glucopyranoside (6), (24S,25R)-spirost-5-en-3β,24-diol 3-O-α-L-rhamnopyranosyl-(1→2)-[β-D-glucopyranosyl-(1→4)-α-L-rhamnopyranosyl-(1→3)]-β-D-glucopyranoside (7), and chantrieroside A (8) were isolated from the rhizomes of Tacca vietnamensis Thin et Hoat. Their chemical structures were elucidated by physical and chemical methods. All compounds were evaluated for the inhibitory activities of nitric oxide production in LPS-stimulated RAW 264.7 macrophages and BV2 cells. As the results, compounds 3–5 showed moderate inhibition on NO production in LPS-stimulated BV2 cells and RAW 264.7 macrophages with the IC50values ranging from 37.0 to 60.7 μM.

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DO - 10.1016/j.bmcl.2016.05.048

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SN - 0960-894X

VL - 26

SP - 3780

EP - 3784

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 15

ER -

Spirostanol saponins from Tacca vietnamensis and their anti-inflammatory activity

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

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