Spirostanol saponins from Tacca vietnamensis and their anti-inflammatory activity

Pham Hai Yen, Vu Thi Quynh Chi, Phan Van Kiem, Bui Huu Tai, Tran Hong Quang, Nguyen Xuan Nhiem, Hoang Le Tuan Anh, Ninh Khac Ban, Bui Van Thanh, Chau Van Minh, Seon Ju Park, Seung Hyun Kim

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Abstract

Using various chromatographic methods, five new steroidal saponins named taccavietnamosides A–E (1–5) and three known, (24S,25R)-spirost-5-en-3β,24-diol 3-O-α-L-rhamnopyranosyl-(1→2)-[α-L-rhamnopyranosyl-(1→3)]-β-D-glucopyranoside (6), (24S,25R)-spirost-5-en-3β,24-diol 3-O-α-L-rhamnopyranosyl-(1→2)-[β-D-glucopyranosyl-(1→4)-α-L-rhamnopyranosyl-(1→3)]-β-D-glucopyranoside (7), and chantrieroside A (8) were isolated from the rhizomes of Tacca vietnamensis Thin et Hoat. Their chemical structures were elucidated by physical and chemical methods. All compounds were evaluated for the inhibitory activities of nitric oxide production in LPS-stimulated RAW 264.7 macrophages and BV2 cells. As the results, compounds 3–5 showed moderate inhibition on NO production in LPS-stimulated BV2 cells and RAW 264.7 macrophages with the IC50values ranging from 37.0 to 60.7 μM.

Original languageEnglish
Pages (from-to)3780-3784
Number of pages5
JournalBioorganic and Medicinal Chemistry Letters
Volume26
Issue number15
DOIs
Publication statusPublished - 2016 Jan 1

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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  • Cite this

    Yen, P. H., Chi, V. T. Q., Kiem, P. V., Tai, B. H., Quang, T. H., Nhiem, N. X., Anh, H. L. T., Ban, N. K., Thanh, B. V., Minh, C. V., Park, S. J., & Kim, S. H. (2016). Spirostanol saponins from Tacca vietnamensis and their anti-inflammatory activity. Bioorganic and Medicinal Chemistry Letters, 26(15), 3780-3784. https://doi.org/10.1016/j.bmcl.2016.05.048