Spirostanol saponins from Tacca vietnamensis and their anti-inflammatory activity

Pham Hai Yen, Vu Thi Quynh Chi, Phan Van Kiem, Bui Huu Tai, Tran Hong Quang, Nguyen Xuan Nhiem, Hoang Le Tuan Anh, Ninh Khac Ban, Bui Van Thanh, Chau Van Minh, Seon Ju Park, Seung Hyun Kim

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Using various chromatographic methods, five new steroidal saponins named taccavietnamosides A–E (1–5) and three known, (24S,25R)-spirost-5-en-3β,24-diol 3-O-α-L-rhamnopyranosyl-(1→2)-[α-L-rhamnopyranosyl-(1→3)]-β-D-glucopyranoside (6), (24S,25R)-spirost-5-en-3β,24-diol 3-O-α-L-rhamnopyranosyl-(1→2)-[β-D-glucopyranosyl-(1→4)-α-L-rhamnopyranosyl-(1→3)]-β-D-glucopyranoside (7), and chantrieroside A (8) were isolated from the rhizomes of Tacca vietnamensis Thin et Hoat. Their chemical structures were elucidated by physical and chemical methods. All compounds were evaluated for the inhibitory activities of nitric oxide production in LPS-stimulated RAW 264.7 macrophages and BV2 cells. As the results, compounds 3–5 showed moderate inhibition on NO production in LPS-stimulated BV2 cells and RAW 264.7 macrophages with the IC 50 values ranging from 37.0 to 60.7 μM.

Original languageEnglish
Pages (from-to)3780-3784
Number of pages5
JournalBioorganic and Medicinal Chemistry Letters
Volume26
Issue number15
DOIs
Publication statusPublished - 2016 Jan 1

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Dioscoreaceae
Spirostans
Macrophages
Saponins
Anti-Inflammatory Agents
Rhizome
Nitric Oxide

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

Cite this

Yen, Pham Hai ; Chi, Vu Thi Quynh ; Kiem, Phan Van ; Tai, Bui Huu ; Quang, Tran Hong ; Nhiem, Nguyen Xuan ; Anh, Hoang Le Tuan ; Ban, Ninh Khac ; Thanh, Bui Van ; Minh, Chau Van ; Park, Seon Ju ; Kim, Seung Hyun. / Spirostanol saponins from Tacca vietnamensis and their anti-inflammatory activity. In: Bioorganic and Medicinal Chemistry Letters. 2016 ; Vol. 26, No. 15. pp. 3780-3784.
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Yen, PH, Chi, VTQ, Kiem, PV, Tai, BH, Quang, TH, Nhiem, NX, Anh, HLT, Ban, NK, Thanh, BV, Minh, CV, Park, SJ & Kim, SH 2016, 'Spirostanol saponins from Tacca vietnamensis and their anti-inflammatory activity', Bioorganic and Medicinal Chemistry Letters, vol. 26, no. 15, pp. 3780-3784. https://doi.org/10.1016/j.bmcl.2016.05.048

Spirostanol saponins from Tacca vietnamensis and their anti-inflammatory activity. / Yen, Pham Hai; Chi, Vu Thi Quynh; Kiem, Phan Van; Tai, Bui Huu; Quang, Tran Hong; Nhiem, Nguyen Xuan; Anh, Hoang Le Tuan; Ban, Ninh Khac; Thanh, Bui Van; Minh, Chau Van; Park, Seon Ju; Kim, Seung Hyun.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 26, No. 15, 01.01.2016, p. 3780-3784.

Research output: Contribution to journalArticle

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T1 - Spirostanol saponins from Tacca vietnamensis and their anti-inflammatory activity

AU - Yen, Pham Hai

AU - Chi, Vu Thi Quynh

AU - Kiem, Phan Van

AU - Tai, Bui Huu

AU - Quang, Tran Hong

AU - Nhiem, Nguyen Xuan

AU - Anh, Hoang Le Tuan

AU - Ban, Ninh Khac

AU - Thanh, Bui Van

AU - Minh, Chau Van

AU - Park, Seon Ju

AU - Kim, Seung Hyun

PY - 2016/1/1

Y1 - 2016/1/1

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