SpONGE: Spontaneous organization of numerous-layer generation by electrospray

Gyuhyung Jin, Mikyung Shin, Seung Hyun Kim, Haeshin Lee, Jae-Hyung Jang

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Advanced technologies that can mimic hierarchical architectures found in nature can provide pivotal clues for elucidating numerous biological mechanisms. Herein, a novel technology, spontaneous organization of numerous-layer generation by electrospray (SpONGE), was developed to create self-assembled and multilayered fibrous structures. The simple inclusion of salts in a polymer solution prior to electrospraying was key to mediating the structural versatilities of the fibrous structures. The SpONGE matrix demonstrated great potential as a crucial building block capable of inducing sequential, localized drug delivery or orchestrating cellular distribution in vivo, thereby expanding its scope of use to cover a variety of biomedical applications. Multilayered, self-assembled, and volume-expanded nanofibrous structures can be formulated by a novel process referred to as the spontaneous organization of numerous-layer generation by electrospray (SpONGE). The SpONGE matrix possesses the unique ability to split multiple individual fibrous layers by manual separation and spatially position biomolecules.

Original languageEnglish
Pages (from-to)7587-7591
Number of pages5
JournalAngewandte Chemie - International Edition
Volume54
Issue number26
DOIs
Publication statusPublished - 2015 Jun 1

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Biomolecules
Polymer solutions
Drug delivery
Salts

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Chemistry(all)

Cite this

Jin, Gyuhyung ; Shin, Mikyung ; Kim, Seung Hyun ; Lee, Haeshin ; Jang, Jae-Hyung. / SpONGE : Spontaneous organization of numerous-layer generation by electrospray. In: Angewandte Chemie - International Edition. 2015 ; Vol. 54, No. 26. pp. 7587-7591.
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SpONGE : Spontaneous organization of numerous-layer generation by electrospray. / Jin, Gyuhyung; Shin, Mikyung; Kim, Seung Hyun; Lee, Haeshin; Jang, Jae-Hyung.

In: Angewandte Chemie - International Edition, Vol. 54, No. 26, 01.06.2015, p. 7587-7591.

Research output: Contribution to journalArticle

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