Spontaneous remission of IgA nephropathy associated with resolution of hepatitis A

SeungHyeok Han, Ea Wha Kang, Jeong Hae Kie, TaeHyun Yoo, Kyu Hun Choi, Dae Suk Han, Shin-Wook Kang

Research output: Contribution to journalArticle

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Abstract

Although most cases of immunoglobulin A (IgA) nephropathy are idiopathic, several diseases are associated with IgA nephropathy. Of these, chronic liver disease resulting from hepatitis B or C virus infection has been reported as a secondary cause of IgA nephropathy. Recently, hepatitis A virus (HAV)-associated kidney disease has received attention because acute kidney injury can occur as a complication of HAV infection, generally caused by acute tubular necrosis or interstitial nephritis. However, unlike IgA nephropathy related to hepatitis B or C, HAV-associated IgA nephropathy is extremely rare and long-term outcomes have not been reported yet. We describe a case of spontaneous remission of IgA nephropathy associated with serologically documented HAV infection. The patient presented with microhematuria and moderate proteinuria, but acute kidney injury did not occur during active hepatic injury. Kidney biopsy specimens clearly showed mesangial IgA deposits with intact tubules and interstitium. Serum liver enzyme levels returned to reference values 1 month after the onset of acute hepatitis, but urinary protein excretion remained increased. Approximately 1 year later, urinary abnormalities were resolved and a second biopsy showed no mesangial IgA deposits. These findings suggest that IgA nephropathy can transiently accompany HAV infection, but may not progress to chronic glomerulonephritis after recovery from HAV.

Original languageEnglish
Pages (from-to)1163-1167
Number of pages5
JournalAmerican Journal of Kidney Diseases
Volume56
Issue number6
DOIs
Publication statusPublished - 2010 Dec 1

Fingerprint

IGA Glomerulonephritis
Spontaneous Remission
Hepatitis A
Hepatitis A virus
Virus Diseases
Acute Kidney Injury
Immunoglobulin A
Biopsy
Interstitial Nephritis
Liver
Kidney Diseases
Hepatitis C
Glomerulonephritis
Hepatitis B
Proteinuria
Hepatitis B virus
Hepacivirus
Hepatitis
Liver Diseases
Reference Values

All Science Journal Classification (ASJC) codes

  • Nephrology

Cite this

Han, SeungHyeok ; Kang, Ea Wha ; Kie, Jeong Hae ; Yoo, TaeHyun ; Choi, Kyu Hun ; Han, Dae Suk ; Kang, Shin-Wook. / Spontaneous remission of IgA nephropathy associated with resolution of hepatitis A. In: American Journal of Kidney Diseases. 2010 ; Vol. 56, No. 6. pp. 1163-1167.
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Spontaneous remission of IgA nephropathy associated with resolution of hepatitis A. / Han, SeungHyeok; Kang, Ea Wha; Kie, Jeong Hae; Yoo, TaeHyun; Choi, Kyu Hun; Han, Dae Suk; Kang, Shin-Wook.

In: American Journal of Kidney Diseases, Vol. 56, No. 6, 01.12.2010, p. 1163-1167.

Research output: Contribution to journalArticle

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