Stabilization of α-helices by the self-assembly of macrocyclic peptides on the surface of gold nanoparticles for molecular recognition

Boram Kim, Sung Ju Choi, So Hee Han, Kang Yell Choi, Yong Beom Lim

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

A novel strategy to stabilize the α-helical secondary structures of peptides upon binding to gold nanoparticles is described. Using a model protein-protein interaction system, we showed that AuNPs decorated with stabilized p53 α-helix peptides can mediate specific molecular recognition with their target protein.

Original languageEnglish
Pages (from-to)7617-7619
Number of pages3
JournalChemical Communications
Volume49
Issue number69
DOIs
Publication statusPublished - 2013 Jan 1

Fingerprint

Molecular recognition
Gold
Self assembly
Peptides
Stabilization
Nanoparticles
Proteins

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

Cite this

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abstract = "A novel strategy to stabilize the α-helical secondary structures of peptides upon binding to gold nanoparticles is described. Using a model protein-protein interaction system, we showed that AuNPs decorated with stabilized p53 α-helix peptides can mediate specific molecular recognition with their target protein.",
author = "Boram Kim and Choi, {Sung Ju} and Han, {So Hee} and Choi, {Kang Yell} and Lim, {Yong Beom}",
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publisher = "Royal Society of Chemistry",
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Stabilization of α-helices by the self-assembly of macrocyclic peptides on the surface of gold nanoparticles for molecular recognition. / Kim, Boram; Choi, Sung Ju; Han, So Hee; Choi, Kang Yell; Lim, Yong Beom.

In: Chemical Communications, Vol. 49, No. 69, 01.01.2013, p. 7617-7619.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Stabilization of α-helices by the self-assembly of macrocyclic peptides on the surface of gold nanoparticles for molecular recognition

AU - Kim, Boram

AU - Choi, Sung Ju

AU - Han, So Hee

AU - Choi, Kang Yell

AU - Lim, Yong Beom

PY - 2013/1/1

Y1 - 2013/1/1

N2 - A novel strategy to stabilize the α-helical secondary structures of peptides upon binding to gold nanoparticles is described. Using a model protein-protein interaction system, we showed that AuNPs decorated with stabilized p53 α-helix peptides can mediate specific molecular recognition with their target protein.

AB - A novel strategy to stabilize the α-helical secondary structures of peptides upon binding to gold nanoparticles is described. Using a model protein-protein interaction system, we showed that AuNPs decorated with stabilized p53 α-helix peptides can mediate specific molecular recognition with their target protein.

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M3 - Article

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JF - Chemical Communications

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