Stabilization of 11/9-helical α/β-peptide foldamers in protic solvents

Mihye Lee, Jihyun Shim, Philjae Kang, Moon-Gun Choi, Soo Hyuk Choi

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

α/β-Peptides with alternating α-amino acid and cis-2-aminocyclohexanecarboxylic acid (cis-ACHC) residues adopt 11/9-helical conformations, the folding propensity of which decreases as the solvent polarity increases. We report a new cis-ACHC analogue, cis-2-amino-cis-4-methylcyclohexanecarboxylic acid, which significantly stabilizes the 11/9-helix propensity in protic solvents.

Original languageEnglish
Pages (from-to)5950-5952
Number of pages3
JournalChemical Communications
Volume52
Issue number35
DOIs
Publication statusPublished - 2016 May 1

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Peptides
Stabilization
Acids
Conformations
Amino Acids
Amino acids
2-aminocyclohexanecarboxylic acid

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

Cite this

Lee, Mihye ; Shim, Jihyun ; Kang, Philjae ; Choi, Moon-Gun ; Choi, Soo Hyuk. / Stabilization of 11/9-helical α/β-peptide foldamers in protic solvents. In: Chemical Communications. 2016 ; Vol. 52, No. 35. pp. 5950-5952.
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Stabilization of 11/9-helical α/β-peptide foldamers in protic solvents. / Lee, Mihye; Shim, Jihyun; Kang, Philjae; Choi, Moon-Gun; Choi, Soo Hyuk.

In: Chemical Communications, Vol. 52, No. 35, 01.05.2016, p. 5950-5952.

Research output: Contribution to journalArticle

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AU - Lee, Mihye

AU - Shim, Jihyun

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AU - Choi, Moon-Gun

AU - Choi, Soo Hyuk

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