Stabilization of 11/9-helical α/β-peptide foldamers in protic solvents

Mihye Lee; Jihyun Shim; Philjae Kang; Moon-Gun Choi; Soo Hyuk Choi

doi:10.1039/c6cc01189f

Stabilization of 11/9-helical α/β-peptide foldamers in protic solvents

Mihye Lee, Jihyun Shim, Philjae Kang, Moon-Gun Choi, Soo Hyuk Choi

Department of Chemistry

Research output: Contribution to journal › Article

6 Citations (Scopus)

Abstract

α/β-Peptides with alternating α-amino acid and cis-2-aminocyclohexanecarboxylic acid (cis-ACHC) residues adopt 11/9-helical conformations, the folding propensity of which decreases as the solvent polarity increases. We report a new cis-ACHC analogue, cis-2-amino-cis-4-methylcyclohexanecarboxylic acid, which significantly stabilizes the 11/9-helix propensity in protic solvents.

Original language	English
Pages (from-to)	5950-5952
Number of pages	3
Journal	Chemical Communications
Volume	52
Issue number	35
DOIs	https://doi.org/10.1039/c6cc01189f
Publication status	Published - 2016 May 1

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All Science Journal Classification (ASJC) codes

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
Chemistry(all)
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

Cite this

Lee, M., Shim, J., Kang, P., Choi, M-G., & Choi, S. H. (2016). Stabilization of 11/9-helical α/β-peptide foldamers in protic solvents. Chemical Communications, 52(35), 5950-5952. https://doi.org/10.1039/c6cc01189f

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AU - Choi, Soo Hyuk

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Access to Document

10.1039/c6cc01189f