Abstract
α/β-Peptides with alternating α-amino acid and cis-2-aminocyclohexanecarboxylic acid (cis-ACHC) residues adopt 11/9-helical conformations, the folding propensity of which decreases as the solvent polarity increases. We report a new cis-ACHC analogue, cis-2-amino-cis-4-methylcyclohexanecarboxylic acid, which significantly stabilizes the 11/9-helix propensity in protic solvents.
| Original language | English |
|---|---|
| Pages (from-to) | 5950-5952 |
| Number of pages | 3 |
| Journal | Chemical Communications |
| Volume | 52 |
| Issue number | 35 |
| DOIs | |
| Publication status | Published - 2016 May 1 |
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All Science Journal Classification (ASJC) codes
- Catalysis
- Electronic, Optical and Magnetic Materials
- Ceramics and Composites
- Chemistry(all)
- Surfaces, Coatings and Films
- Metals and Alloys
- Materials Chemistry
Cite this
}
Stabilization of 11/9-helical α/β-peptide foldamers in protic solvents. / Lee, Mihye; Shim, Jihyun; Kang, Philjae; Choi, Moon-Gun; Choi, Soo Hyuk.
In: Chemical Communications, Vol. 52, No. 35, 01.05.2016, p. 5950-5952.Research output: Contribution to journal › Article
TY - JOUR
T1 - Stabilization of 11/9-helical α/β-peptide foldamers in protic solvents
AU - Lee, Mihye
AU - Shim, Jihyun
AU - Kang, Philjae
AU - Choi, Moon-Gun
AU - Choi, Soo Hyuk
PY - 2016/5/1
Y1 - 2016/5/1
N2 - α/β-Peptides with alternating α-amino acid and cis-2-aminocyclohexanecarboxylic acid (cis-ACHC) residues adopt 11/9-helical conformations, the folding propensity of which decreases as the solvent polarity increases. We report a new cis-ACHC analogue, cis-2-amino-cis-4-methylcyclohexanecarboxylic acid, which significantly stabilizes the 11/9-helix propensity in protic solvents.
AB - α/β-Peptides with alternating α-amino acid and cis-2-aminocyclohexanecarboxylic acid (cis-ACHC) residues adopt 11/9-helical conformations, the folding propensity of which decreases as the solvent polarity increases. We report a new cis-ACHC analogue, cis-2-amino-cis-4-methylcyclohexanecarboxylic acid, which significantly stabilizes the 11/9-helix propensity in protic solvents.
UR - http://www.scopus.com/inward/record.url?scp=84966963770&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84966963770&partnerID=8YFLogxK
U2 - 10.1039/c6cc01189f
DO - 10.1039/c6cc01189f
M3 - Article
C2 - 27056400
AN - SCOPUS:84966963770
VL - 52
SP - 5950
EP - 5952
JO - Chemical Communications
JF - Chemical Communications
SN - 1359-7345
IS - 35
ER -