Stacked graphene nanofibers for electrochemical oxidation of DNA bases

Adriano Ambrosi, Martin Pumera

Research output: Contribution to journalArticle

72 Citations (Scopus)

Abstract

In this article, we show that stacked graphene nanofibers (SGNFs) demonstrate superior electrochemical performance for oxidation of DNA bases over carbon nanotubes (CNTs). This is due to an exceptionally high number of accessible graphene sheet edges on the surface of the nanofibers when compared to carbon nanotubes, as shown by transmission electron microscopy and Raman spectroscopy. The oxidation signals of adenine, guanine, cytosine, and thymine exhibit two to four times higher currents than on CNT-based electrodes. SGNFs also exhibit higher sensitivity than do edge-plane pyrolytic graphite, glassy carbon, or graphite microparticle-based electrodes. We also demonstrate that influenza A(H1N1)-related strands can be sensitively oxidized on SGNF-based electrodes, which could therefore be applied to label-free DNA analysis.

Original languageEnglish
Pages (from-to)8943-8947
Number of pages5
JournalPhysical Chemistry Chemical Physics
Volume12
Issue number31
DOIs
Publication statusPublished - 2010 Aug 21

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Graphite
electrochemical oxidation
Electrochemical oxidation
Nanofibers
graphene
deoxyribonucleic acid
Carbon Nanotubes
DNA
carbon nanotubes
electrodes
influenza
oxidation
Electrodes
thymine
guanines
pyrolytic graphite
glassy carbon
adenines
microparticles
strands

All Science Journal Classification (ASJC) codes

  • Physics and Astronomy(all)
  • Physical and Theoretical Chemistry

Cite this

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Stacked graphene nanofibers for electrochemical oxidation of DNA bases. / Ambrosi, Adriano; Pumera, Martin.

In: Physical Chemistry Chemical Physics, Vol. 12, No. 31, 21.08.2010, p. 8943-8947.

Research output: Contribution to journalArticle

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