Staging laparoscopy for the management of early-stage ovarian cancer

A metaanalysis

Hyun Jong Park, Dong Wook Kim, Ga Won Yim, Eun Ji Nam, Sunghoon Kim, YoungTae Kim

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

OBJECTIVE: We sought to perform a quantitative analysis on operative outcomes of laparoscopic staging surgery in patients with presumed early-stage ovarian cancer using a metaanalysis. STUDY DESIGN: Electronic searches for studies of laparoscopic staging surgery in patients with ovarian cancer were performed within 3 electronic databases (Medline, Embase, and the Cochrane Library) using the key words "ovarian cancer," "early stage," "laparoscopy," "staging surgery," "staging laparoscopy," and "recurrence." Two authors independently screened articles, and those meeting the defined inclusion/exclusion criteria were included in the metaanalysis. RESULTS: We identified 11 observational studies. The combined results of 3 retrospective studies showed that the estimated blood loss in laparoscopy was significantly lower than that for laparotomy (P < .001). The overall upstaging rate after laparoscopic surgery was 22.6% (95% confidence interval [CI], 18.1e27.9%) without significant heterogeneity among all study results. The overall incidence of conversion from laparoscopy to laparotomy was 3.7% (95% CI, 2.0e6.9%). The overall rate of recurrence in studies with a median follow-up period of 19 months was 9.9% (95% CI, 6.7e14.4%). CONCLUSION: Through our quantitative analysis, we concluded that the operative outcomes of a laparoscopic approach in patients with early-stage ovarian cancer could be compatible with those of laparotomy. In the future, further randomized controlled trials may be needed.

Original languageEnglish
Pages (from-to)58.e1-58.e8
JournalAmerican Journal of Obstetrics and Gynecology
Volume209
Issue number1
DOIs
Publication statusPublished - 2013 Jan 1

Fingerprint

Ovarian Neoplasms
Laparoscopy
Laparotomy
Confidence Intervals
Recurrence
Libraries
Observational Studies
Randomized Controlled Trials
Retrospective Studies
Databases
Incidence

All Science Journal Classification (ASJC) codes

  • Obstetrics and Gynaecology

Cite this

Park, Hyun Jong ; Kim, Dong Wook ; Yim, Ga Won ; Nam, Eun Ji ; Kim, Sunghoon ; Kim, YoungTae. / Staging laparoscopy for the management of early-stage ovarian cancer : A metaanalysis. In: American Journal of Obstetrics and Gynecology. 2013 ; Vol. 209, No. 1. pp. 58.e1-58.e8.
@article{5fbff7ec7054492c94164e75c1fb5fa4,
title = "Staging laparoscopy for the management of early-stage ovarian cancer: A metaanalysis",
abstract = "OBJECTIVE: We sought to perform a quantitative analysis on operative outcomes of laparoscopic staging surgery in patients with presumed early-stage ovarian cancer using a metaanalysis. STUDY DESIGN: Electronic searches for studies of laparoscopic staging surgery in patients with ovarian cancer were performed within 3 electronic databases (Medline, Embase, and the Cochrane Library) using the key words {"}ovarian cancer,{"} {"}early stage,{"} {"}laparoscopy,{"} {"}staging surgery,{"} {"}staging laparoscopy,{"} and {"}recurrence.{"} Two authors independently screened articles, and those meeting the defined inclusion/exclusion criteria were included in the metaanalysis. RESULTS: We identified 11 observational studies. The combined results of 3 retrospective studies showed that the estimated blood loss in laparoscopy was significantly lower than that for laparotomy (P < .001). The overall upstaging rate after laparoscopic surgery was 22.6{\%} (95{\%} confidence interval [CI], 18.1e27.9{\%}) without significant heterogeneity among all study results. The overall incidence of conversion from laparoscopy to laparotomy was 3.7{\%} (95{\%} CI, 2.0e6.9{\%}). The overall rate of recurrence in studies with a median follow-up period of 19 months was 9.9{\%} (95{\%} CI, 6.7e14.4{\%}). CONCLUSION: Through our quantitative analysis, we concluded that the operative outcomes of a laparoscopic approach in patients with early-stage ovarian cancer could be compatible with those of laparotomy. In the future, further randomized controlled trials may be needed.",
author = "Park, {Hyun Jong} and Kim, {Dong Wook} and Yim, {Ga Won} and Nam, {Eun Ji} and Sunghoon Kim and YoungTae Kim",
year = "2013",
month = "1",
day = "1",
doi = "10.1016/j.ajog.2013.04.013",
language = "English",
volume = "209",
pages = "58.e1--58.e8",
journal = "American Journal of Obstetrics and Gynecology",
issn = "0002-9378",
publisher = "Mosby Inc.",
number = "1",

}

Staging laparoscopy for the management of early-stage ovarian cancer : A metaanalysis. / Park, Hyun Jong; Kim, Dong Wook; Yim, Ga Won; Nam, Eun Ji; Kim, Sunghoon; Kim, YoungTae.

In: American Journal of Obstetrics and Gynecology, Vol. 209, No. 1, 01.01.2013, p. 58.e1-58.e8.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Staging laparoscopy for the management of early-stage ovarian cancer

T2 - A metaanalysis

AU - Park, Hyun Jong

AU - Kim, Dong Wook

AU - Yim, Ga Won

AU - Nam, Eun Ji

AU - Kim, Sunghoon

AU - Kim, YoungTae

PY - 2013/1/1

Y1 - 2013/1/1

N2 - OBJECTIVE: We sought to perform a quantitative analysis on operative outcomes of laparoscopic staging surgery in patients with presumed early-stage ovarian cancer using a metaanalysis. STUDY DESIGN: Electronic searches for studies of laparoscopic staging surgery in patients with ovarian cancer were performed within 3 electronic databases (Medline, Embase, and the Cochrane Library) using the key words "ovarian cancer," "early stage," "laparoscopy," "staging surgery," "staging laparoscopy," and "recurrence." Two authors independently screened articles, and those meeting the defined inclusion/exclusion criteria were included in the metaanalysis. RESULTS: We identified 11 observational studies. The combined results of 3 retrospective studies showed that the estimated blood loss in laparoscopy was significantly lower than that for laparotomy (P < .001). The overall upstaging rate after laparoscopic surgery was 22.6% (95% confidence interval [CI], 18.1e27.9%) without significant heterogeneity among all study results. The overall incidence of conversion from laparoscopy to laparotomy was 3.7% (95% CI, 2.0e6.9%). The overall rate of recurrence in studies with a median follow-up period of 19 months was 9.9% (95% CI, 6.7e14.4%). CONCLUSION: Through our quantitative analysis, we concluded that the operative outcomes of a laparoscopic approach in patients with early-stage ovarian cancer could be compatible with those of laparotomy. In the future, further randomized controlled trials may be needed.

AB - OBJECTIVE: We sought to perform a quantitative analysis on operative outcomes of laparoscopic staging surgery in patients with presumed early-stage ovarian cancer using a metaanalysis. STUDY DESIGN: Electronic searches for studies of laparoscopic staging surgery in patients with ovarian cancer were performed within 3 electronic databases (Medline, Embase, and the Cochrane Library) using the key words "ovarian cancer," "early stage," "laparoscopy," "staging surgery," "staging laparoscopy," and "recurrence." Two authors independently screened articles, and those meeting the defined inclusion/exclusion criteria were included in the metaanalysis. RESULTS: We identified 11 observational studies. The combined results of 3 retrospective studies showed that the estimated blood loss in laparoscopy was significantly lower than that for laparotomy (P < .001). The overall upstaging rate after laparoscopic surgery was 22.6% (95% confidence interval [CI], 18.1e27.9%) without significant heterogeneity among all study results. The overall incidence of conversion from laparoscopy to laparotomy was 3.7% (95% CI, 2.0e6.9%). The overall rate of recurrence in studies with a median follow-up period of 19 months was 9.9% (95% CI, 6.7e14.4%). CONCLUSION: Through our quantitative analysis, we concluded that the operative outcomes of a laparoscopic approach in patients with early-stage ovarian cancer could be compatible with those of laparotomy. In the future, further randomized controlled trials may be needed.

UR - http://www.scopus.com/inward/record.url?scp=84880133938&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84880133938&partnerID=8YFLogxK

U2 - 10.1016/j.ajog.2013.04.013

DO - 10.1016/j.ajog.2013.04.013

M3 - Article

VL - 209

SP - 58.e1-58.e8

JO - American Journal of Obstetrics and Gynecology

JF - American Journal of Obstetrics and Gynecology

SN - 0002-9378

IS - 1

ER -