Standardized Herbal Formula PM014 Inhibits Radiation-Induced Pulmonary Inflammation in Mice

Jee Youn Kim, Dasom Shin, Gihyun Lee, Jin Mo Kim, Dongwook Kim, Yong Min An, Byung Rok Yoo, Hanna Chang, Miran Kim, Jaeho Cho, Hyunsu Bae

Research output: Contribution to journalArticle

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Abstract

Radiation therapy is widely used for thoracic cancers. However, it occasionally causes radiation-induced lung injuries, including pneumonitis and fibrosis. Chung-Sang-Bo-Ha-Tang (CSBHT) has been traditionally used to treat chronic pulmonary disease in Korea. PM014, a modified herbal formula derived from CSBHT, contains medicinal herbs of seven species. In our previous studies, PM014 exhibited anti-inflammatory effects in a chronic obstructive pulmonary disease model. In this study, we have evaluated the effects of PM014 on radiation-induced lung inflammation. Mice in the treatment group were orally administered PM014 six times for 2 weeks. Effects of PM014 on radiation pneumonitis were evaluated based on histological findings and differential cell count in bronchoalveolar lavage fluid. PM014 treatment significantly inhibited immune cell recruitment and collagen deposition in lung tissue. Normal lung volume, evaluated by radiological analysis, in PM014-treated mice was higher compared to that in irradiated control mice. PM014-treated mice exhibited significant changes in inspiratory capacity, compliance and tissue damping and elastance. Additionally, PM014 treatment resulted in the downregulation of inflammatory cytokines, chemokines, and fibrosis-related genes and a reduction in the transforming growth factor-β1-positive cell population in lung tissue. Thus, PM014 is a potent therapeutic agent for radiation-induced lung fibrosis and inflammation.

Original languageEnglish
Article number45001
JournalScientific reports
Volume7
DOIs
Publication statusPublished - 2017 Mar 21

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Pneumonia
Radiation
Fibrosis
Lung
Inspiratory Capacity
Radiation Pneumonitis
Bronchoalveolar Lavage Fluid
Lung Injury
Transforming Growth Factors
Therapeutics
Medicinal Plants
Korea
Chemokines
Chronic Obstructive Pulmonary Disease
Lung Diseases
Compliance
Chronic Disease
Anti-Inflammatory Agents
Collagen
Radiotherapy

All Science Journal Classification (ASJC) codes

  • General

Cite this

Kim, J. Y., Shin, D., Lee, G., Kim, J. M., Kim, D., An, Y. M., ... Bae, H. (2017). Standardized Herbal Formula PM014 Inhibits Radiation-Induced Pulmonary Inflammation in Mice. Scientific reports, 7, [45001]. https://doi.org/10.1038/srep45001
Kim, Jee Youn ; Shin, Dasom ; Lee, Gihyun ; Kim, Jin Mo ; Kim, Dongwook ; An, Yong Min ; Yoo, Byung Rok ; Chang, Hanna ; Kim, Miran ; Cho, Jaeho ; Bae, Hyunsu. / Standardized Herbal Formula PM014 Inhibits Radiation-Induced Pulmonary Inflammation in Mice. In: Scientific reports. 2017 ; Vol. 7.
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abstract = "Radiation therapy is widely used for thoracic cancers. However, it occasionally causes radiation-induced lung injuries, including pneumonitis and fibrosis. Chung-Sang-Bo-Ha-Tang (CSBHT) has been traditionally used to treat chronic pulmonary disease in Korea. PM014, a modified herbal formula derived from CSBHT, contains medicinal herbs of seven species. In our previous studies, PM014 exhibited anti-inflammatory effects in a chronic obstructive pulmonary disease model. In this study, we have evaluated the effects of PM014 on radiation-induced lung inflammation. Mice in the treatment group were orally administered PM014 six times for 2 weeks. Effects of PM014 on radiation pneumonitis were evaluated based on histological findings and differential cell count in bronchoalveolar lavage fluid. PM014 treatment significantly inhibited immune cell recruitment and collagen deposition in lung tissue. Normal lung volume, evaluated by radiological analysis, in PM014-treated mice was higher compared to that in irradiated control mice. PM014-treated mice exhibited significant changes in inspiratory capacity, compliance and tissue damping and elastance. Additionally, PM014 treatment resulted in the downregulation of inflammatory cytokines, chemokines, and fibrosis-related genes and a reduction in the transforming growth factor-β1-positive cell population in lung tissue. Thus, PM014 is a potent therapeutic agent for radiation-induced lung fibrosis and inflammation.",
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Kim, JY, Shin, D, Lee, G, Kim, JM, Kim, D, An, YM, Yoo, BR, Chang, H, Kim, M, Cho, J & Bae, H 2017, 'Standardized Herbal Formula PM014 Inhibits Radiation-Induced Pulmonary Inflammation in Mice', Scientific reports, vol. 7, 45001. https://doi.org/10.1038/srep45001

Standardized Herbal Formula PM014 Inhibits Radiation-Induced Pulmonary Inflammation in Mice. / Kim, Jee Youn; Shin, Dasom; Lee, Gihyun; Kim, Jin Mo; Kim, Dongwook; An, Yong Min; Yoo, Byung Rok; Chang, Hanna; Kim, Miran; Cho, Jaeho; Bae, Hyunsu.

In: Scientific reports, Vol. 7, 45001, 21.03.2017.

Research output: Contribution to journalArticle

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T1 - Standardized Herbal Formula PM014 Inhibits Radiation-Induced Pulmonary Inflammation in Mice

AU - Kim, Jee Youn

AU - Shin, Dasom

AU - Lee, Gihyun

AU - Kim, Jin Mo

AU - Kim, Dongwook

AU - An, Yong Min

AU - Yoo, Byung Rok

AU - Chang, Hanna

AU - Kim, Miran

AU - Cho, Jaeho

AU - Bae, Hyunsu

PY - 2017/3/21

Y1 - 2017/3/21

N2 - Radiation therapy is widely used for thoracic cancers. However, it occasionally causes radiation-induced lung injuries, including pneumonitis and fibrosis. Chung-Sang-Bo-Ha-Tang (CSBHT) has been traditionally used to treat chronic pulmonary disease in Korea. PM014, a modified herbal formula derived from CSBHT, contains medicinal herbs of seven species. In our previous studies, PM014 exhibited anti-inflammatory effects in a chronic obstructive pulmonary disease model. In this study, we have evaluated the effects of PM014 on radiation-induced lung inflammation. Mice in the treatment group were orally administered PM014 six times for 2 weeks. Effects of PM014 on radiation pneumonitis were evaluated based on histological findings and differential cell count in bronchoalveolar lavage fluid. PM014 treatment significantly inhibited immune cell recruitment and collagen deposition in lung tissue. Normal lung volume, evaluated by radiological analysis, in PM014-treated mice was higher compared to that in irradiated control mice. PM014-treated mice exhibited significant changes in inspiratory capacity, compliance and tissue damping and elastance. Additionally, PM014 treatment resulted in the downregulation of inflammatory cytokines, chemokines, and fibrosis-related genes and a reduction in the transforming growth factor-β1-positive cell population in lung tissue. Thus, PM014 is a potent therapeutic agent for radiation-induced lung fibrosis and inflammation.

AB - Radiation therapy is widely used for thoracic cancers. However, it occasionally causes radiation-induced lung injuries, including pneumonitis and fibrosis. Chung-Sang-Bo-Ha-Tang (CSBHT) has been traditionally used to treat chronic pulmonary disease in Korea. PM014, a modified herbal formula derived from CSBHT, contains medicinal herbs of seven species. In our previous studies, PM014 exhibited anti-inflammatory effects in a chronic obstructive pulmonary disease model. In this study, we have evaluated the effects of PM014 on radiation-induced lung inflammation. Mice in the treatment group were orally administered PM014 six times for 2 weeks. Effects of PM014 on radiation pneumonitis were evaluated based on histological findings and differential cell count in bronchoalveolar lavage fluid. PM014 treatment significantly inhibited immune cell recruitment and collagen deposition in lung tissue. Normal lung volume, evaluated by radiological analysis, in PM014-treated mice was higher compared to that in irradiated control mice. PM014-treated mice exhibited significant changes in inspiratory capacity, compliance and tissue damping and elastance. Additionally, PM014 treatment resulted in the downregulation of inflammatory cytokines, chemokines, and fibrosis-related genes and a reduction in the transforming growth factor-β1-positive cell population in lung tissue. Thus, PM014 is a potent therapeutic agent for radiation-induced lung fibrosis and inflammation.

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