Staphylococcal enterotoxin sensitization in a community-based population

A potential role in adult-onset asthma

W. J. Song, Y. S. Chang, M. K. Lim, E. H. Yun, SeHoon Kim, H. R. Kang, H. W. Park, P. Tomassen, M. H. Choi, K. U. Min, S. H. Cho, C. Bachert

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Summary: Background: Recent studies suggest that Staphylococcus aureus enterotoxin sensitization is a risk factor for asthma. However, there is a paucity of epidemiologic evidence on adult-onset asthma in community-based populations. Objective: We sought to evaluate the epidemiology and the clinical significance of staphylococcal enterotoxin sensitization in community-based adult populations. Methods: The present analyses were performed using the baseline data set of Korean adult population surveys, consisting of 1080 adults (mean age = 60.2 years) recruited from an urban and a rural community. Questionnaires, methacholine challenge tests, and allergen skin tests were performed for defining clinical phenotypes. Sera were analysed for total IgE and enterotoxin-specific IgE using ImmunoCAP. Results: Staphylococcal enterotoxin sensitization (≥ 0.35 kU/L) had a prevalence of 27.0%. Risk factors were identified as male sex, current smoking, advanced age (≥ 61 years), and inhalant allergen sensitization. Current asthma was mostly adult onset (≥ 18 years old) and showed independent associations with high enterotoxin-specific IgE levels in multivariate logistic regression tests. In multivariate linear regressions, staphylococcal enterotoxin-specific IgE level was identified as the major determinant factor for total IgE level. Conclusions and Clinical Relevance: Staphylococcal enterotoxin sensitization was independently associated with adult-onset asthma in adult community populations. Strong correlations between the enterotoxin-specific IgE and total IgE levels support the clinical significance. The present findings warrant further studies for the precise roles of staphylococcal enterotoxin sensitization in the asthma pathogenesis.

Original languageEnglish
Pages (from-to)553-562
Number of pages10
JournalClinical and Experimental Allergy
Volume44
Issue number4
DOIs
Publication statusPublished - 2014 Jan 1

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Enterotoxins
Asthma
Immunoglobulin E
Population
Allergens
Methacholine Chloride
Rural Population
Skin Tests
Staphylococcus aureus
Linear Models
Epidemiology
Logistic Models
Smoking
Phenotype

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

Cite this

Song, W. J. ; Chang, Y. S. ; Lim, M. K. ; Yun, E. H. ; Kim, SeHoon ; Kang, H. R. ; Park, H. W. ; Tomassen, P. ; Choi, M. H. ; Min, K. U. ; Cho, S. H. ; Bachert, C. / Staphylococcal enterotoxin sensitization in a community-based population : A potential role in adult-onset asthma. In: Clinical and Experimental Allergy. 2014 ; Vol. 44, No. 4. pp. 553-562.
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abstract = "Summary: Background: Recent studies suggest that Staphylococcus aureus enterotoxin sensitization is a risk factor for asthma. However, there is a paucity of epidemiologic evidence on adult-onset asthma in community-based populations. Objective: We sought to evaluate the epidemiology and the clinical significance of staphylococcal enterotoxin sensitization in community-based adult populations. Methods: The present analyses were performed using the baseline data set of Korean adult population surveys, consisting of 1080 adults (mean age = 60.2 years) recruited from an urban and a rural community. Questionnaires, methacholine challenge tests, and allergen skin tests were performed for defining clinical phenotypes. Sera were analysed for total IgE and enterotoxin-specific IgE using ImmunoCAP. Results: Staphylococcal enterotoxin sensitization (≥ 0.35 kU/L) had a prevalence of 27.0{\%}. Risk factors were identified as male sex, current smoking, advanced age (≥ 61 years), and inhalant allergen sensitization. Current asthma was mostly adult onset (≥ 18 years old) and showed independent associations with high enterotoxin-specific IgE levels in multivariate logistic regression tests. In multivariate linear regressions, staphylococcal enterotoxin-specific IgE level was identified as the major determinant factor for total IgE level. Conclusions and Clinical Relevance: Staphylococcal enterotoxin sensitization was independently associated with adult-onset asthma in adult community populations. Strong correlations between the enterotoxin-specific IgE and total IgE levels support the clinical significance. The present findings warrant further studies for the precise roles of staphylococcal enterotoxin sensitization in the asthma pathogenesis.",
author = "Song, {W. J.} and Chang, {Y. S.} and Lim, {M. K.} and Yun, {E. H.} and SeHoon Kim and Kang, {H. R.} and Park, {H. W.} and P. Tomassen and Choi, {M. H.} and Min, {K. U.} and Cho, {S. H.} and C. Bachert",
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Song, WJ, Chang, YS, Lim, MK, Yun, EH, Kim, S, Kang, HR, Park, HW, Tomassen, P, Choi, MH, Min, KU, Cho, SH & Bachert, C 2014, 'Staphylococcal enterotoxin sensitization in a community-based population: A potential role in adult-onset asthma', Clinical and Experimental Allergy, vol. 44, no. 4, pp. 553-562. https://doi.org/10.1111/cea.12239

Staphylococcal enterotoxin sensitization in a community-based population : A potential role in adult-onset asthma. / Song, W. J.; Chang, Y. S.; Lim, M. K.; Yun, E. H.; Kim, SeHoon; Kang, H. R.; Park, H. W.; Tomassen, P.; Choi, M. H.; Min, K. U.; Cho, S. H.; Bachert, C.

In: Clinical and Experimental Allergy, Vol. 44, No. 4, 01.01.2014, p. 553-562.

Research output: Contribution to journalArticle

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T1 - Staphylococcal enterotoxin sensitization in a community-based population

T2 - A potential role in adult-onset asthma

AU - Song, W. J.

AU - Chang, Y. S.

AU - Lim, M. K.

AU - Yun, E. H.

AU - Kim, SeHoon

AU - Kang, H. R.

AU - Park, H. W.

AU - Tomassen, P.

AU - Choi, M. H.

AU - Min, K. U.

AU - Cho, S. H.

AU - Bachert, C.

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Summary: Background: Recent studies suggest that Staphylococcus aureus enterotoxin sensitization is a risk factor for asthma. However, there is a paucity of epidemiologic evidence on adult-onset asthma in community-based populations. Objective: We sought to evaluate the epidemiology and the clinical significance of staphylococcal enterotoxin sensitization in community-based adult populations. Methods: The present analyses were performed using the baseline data set of Korean adult population surveys, consisting of 1080 adults (mean age = 60.2 years) recruited from an urban and a rural community. Questionnaires, methacholine challenge tests, and allergen skin tests were performed for defining clinical phenotypes. Sera were analysed for total IgE and enterotoxin-specific IgE using ImmunoCAP. Results: Staphylococcal enterotoxin sensitization (≥ 0.35 kU/L) had a prevalence of 27.0%. Risk factors were identified as male sex, current smoking, advanced age (≥ 61 years), and inhalant allergen sensitization. Current asthma was mostly adult onset (≥ 18 years old) and showed independent associations with high enterotoxin-specific IgE levels in multivariate logistic regression tests. In multivariate linear regressions, staphylococcal enterotoxin-specific IgE level was identified as the major determinant factor for total IgE level. Conclusions and Clinical Relevance: Staphylococcal enterotoxin sensitization was independently associated with adult-onset asthma in adult community populations. Strong correlations between the enterotoxin-specific IgE and total IgE levels support the clinical significance. The present findings warrant further studies for the precise roles of staphylococcal enterotoxin sensitization in the asthma pathogenesis.

AB - Summary: Background: Recent studies suggest that Staphylococcus aureus enterotoxin sensitization is a risk factor for asthma. However, there is a paucity of epidemiologic evidence on adult-onset asthma in community-based populations. Objective: We sought to evaluate the epidemiology and the clinical significance of staphylococcal enterotoxin sensitization in community-based adult populations. Methods: The present analyses were performed using the baseline data set of Korean adult population surveys, consisting of 1080 adults (mean age = 60.2 years) recruited from an urban and a rural community. Questionnaires, methacholine challenge tests, and allergen skin tests were performed for defining clinical phenotypes. Sera were analysed for total IgE and enterotoxin-specific IgE using ImmunoCAP. Results: Staphylococcal enterotoxin sensitization (≥ 0.35 kU/L) had a prevalence of 27.0%. Risk factors were identified as male sex, current smoking, advanced age (≥ 61 years), and inhalant allergen sensitization. Current asthma was mostly adult onset (≥ 18 years old) and showed independent associations with high enterotoxin-specific IgE levels in multivariate logistic regression tests. In multivariate linear regressions, staphylococcal enterotoxin-specific IgE level was identified as the major determinant factor for total IgE level. Conclusions and Clinical Relevance: Staphylococcal enterotoxin sensitization was independently associated with adult-onset asthma in adult community populations. Strong correlations between the enterotoxin-specific IgE and total IgE levels support the clinical significance. The present findings warrant further studies for the precise roles of staphylococcal enterotoxin sensitization in the asthma pathogenesis.

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